| Structural basis for hyperpolarization-dependent opening of human HCN1 channel. | Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Burtscher V, Mount J, Huang J, Cowgill J, Chang Y, Bickel K, Chen J, Yuan P, Chanda B., Free PMC Article | 06/24/2024 |
| HCN1 pathogenic variants associated with childhood epilepsy in a cohort of Chinese patients. | HCN1 pathogenic variants associated with childhood epilepsy in a cohort of Chinese patients.
Yang Z, Kuang Z, Liao H, Gan S, Peng X, Yang H, Wu L. | 02/26/2024 |
| The Impact of Altered HCN1 Expression on Brain Function and Its Relationship with Epileptogenesis. | The Impact of Altered HCN1 Expression on Brain Function and Its Relationship with Epileptogenesis.
Zhao K, Li Y, Yang X, Zhou L., Free PMC Article | 08/25/2023 |
| Do the functional properties of HCN1 mutants correlate with the clinical features in epileptic patients? | Do the functional properties of HCN1 mutants correlate with the clinical features in epileptic patients?
Porro A, Abbandonato G, Veronesi V, Russo A, Binda A, Antolini L, Granata T, Castellotti B, Marini C, Moroni A, DiFrancesco JC, Rivolta I. | 02/5/2022 |
| Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling. | Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling.
Hung A, Forster IC, Mckenzie CE, Berecki G, Petrou S, Kathirvel A, Soh MS, Reid CA. | 02/5/2022 |
| HCN1 channels: A versatile tool for signal processing by primary sensory neurons. | HCN1 channels: A versatile tool for signal processing by primary sensory neurons.
Barravecchia I, Demontis GC. | 02/5/2022 |
| Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice. | Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.
Schlusche AK, Vay SU, Kleinenkuhnen N, Sandke S, Campos-Martín R, Florio M, Huttner W, Tresch A, Roeper J, Rueger MA, Jakovcevski I, Stockebrand M, Isbrandt D., Free PMC Article | 12/18/2021 |
| Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). | Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS).
Lin W, Qin J, Ni G, Li Y, Xie H, Yu J, Li H, Sui L, Guo Q, Fang Z, Zhou L. | 11/27/2021 |
| Mutating two residues of HCN1 located at the interface between the voltage sensor and the pore domain resulted in the open state upon depolarization instead of hyperpolarization. | Gating mechanism of hyperpolarization-activated HCN pacemaker channels.
Ramentol R, Perez ME, Larsson HP., Free PMC Article | 08/1/2020 |
| All-atom molecular dynamics simulations (~20 mus) of HCN1 channel under hyperpolarization reveals an initial downward movement of the S4 voltage-sensor but following the transfer of last gating charge, the S4 breaks into two sub-helices with the lower sub-helix becoming parallel to the membrane. | Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating.
Kasimova MA, Tewari D, Cowgill JB, Ursuleaz WC, Lin JL, Delemotte L, Chanda B., Free PMC Article | 05/9/2020 |
| Study found stronger h-channel (HCN1)-related membrane properties in supragranular pyramidal neurons in human temporal cortex, compared to mouse supragranular pyramidal neurons in temporal association area. H-channels contribute to between-species differences in a fundamental neuronal property. | h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex.
Kalmbach BE, Buchin A, Long B, Close J, Nandi A, Miller JA, Bakken TE, Hodge RD, Chong P, de Frates R, Dai K, Maltzer Z, Nicovich PR, Keene CD, Silbergeld DL, Gwinn RP, Cobbs C, Ko AL, Ojemann JG, Koch C, Anastassiou CA, Lein ES, Ting JT., Free PMC Article | 08/24/2019 |
| The results expand the clinical spectrum related to HCN1 variants to include common generalized epilepsy phenotypes and further illustrate how HCN1 has a pivotal function in brain development and control of neuronal excitability. | HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond.
Marini C, Porro A, Rastetter A, Dalle C, Rivolta I, Bauer D, Oegema R, Nava C, Parrini E, Mei D, Mercer C, Dhamija R, Chambers C, Coubes C, Thévenon J, Kuentz P, Julia S, Pasquier L, Dubourg C, Carré W, Rosati A, Melani F, Pisano T, Giardino M, Innes AM, Alembik Y, Scheidecker S, Santos M, Figueiroa S, Garrido C, Fusco C, Frattini D, Spagnoli C, Binda A, Granata T, Ragona F, Freri E, Franceschetti S, Canafoglia L, Castellotti B, Gellera C, Milanesi R, Mancardi MM, Clark DR, Kok F, Helbig KL, Ichikawa S, Sadler L, Neupauerová J, Laššuthova P, Šterbová K, Laridon A, Brilstra E, Koeleman B, Lemke JR, Zara F, Striano P, Soblet J, Smits G, Deconinck N, Barbuti A, DiFrancesco D, LeGuern E, Guerrini R, Santoro B, Hamacher K, Thiel G, Moroni A, DiFrancesco JC, Depienne C. | 07/20/2019 |
| No significant association was found between HCN1/HCN2 alleles, genotypes or haplotypes, and drug resistance in patients, however, it was suggested that HCN2 rs3752158 is involved in the susceptibility to juvenile myoclonic epilepsy. | Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.
Wu SZ, Ye H, Yang XG, Lu ZL, Qu Q, Qu J. | 05/25/2019 |
| this study provides evidence that the HCN1 is candidate genes for Dravet and Dravet-like phenotypes. | Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome.
Wang J, Wen Y, Zhang Q, Yu S, Chen Y, Wu X, Zhang Y, Bao X. | 04/20/2019 |
| Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel. | Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel.
Gross C, Saponaro A, Santoro B, Moroni A, Thiel G, Hamacher K., Free PMC Article | 02/16/2019 |
| Polymorphism of HCN1 is associated with breast cancer. | Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.
Kuo SH, Yang SY, You SL, Lien HC, Lin CH, Lin PH, Huang CS., Free PMC Article | 10/14/2017 |
| Study presents cryo-electron microscopy structures of the human HCN1 channel in the absence and presence of cAMP at 3.5 A resolution. HCN channels contain a K(+) channel selectivity filter-forming sequence from which the amino acids create a unique structure that explains Na(+) and K(+) permeability. | Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Lee CH, MacKinnon R., Free PMC Article | 05/13/2017 |
| A new mode of regulating HCN1 trafficking: through the use of a di-arginine ER retention signal that monitors processing of the channel in the early secretory pathway. | A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane.
Pan Y, Laird JG, Yamaguchi DM, Baker SA., Free PMC Article | 04/11/2015 |
| de novo HCN1 point mutations cause a recognizable early-onset epileptic encephalopathy in humans | De novo mutations in HCN1 cause early infantile epileptic encephalopathy.
Nava C, Dalle C, Rastetter A, Striano P, de Kovel CG, Nabbout R, Cancès C, Ville D, Brilstra EH, Gobbi G, Raffo E, Bouteiller D, Marie Y, Trouillard O, Robbiano A, Keren B, Agher D, Roze E, Lesage S, Nicolas A, Brice A, Baulac M, Vogt C, El Hajj N, Schneider E, Suls A, Weckhuysen S, Gormley P, Lehesjoki AE, De Jonghe P, Helbig I, Baulac S, Zara F, Koeleman BP, EuroEPINOMICS RES Consortium, Haaf T, LeGuern E, Depienne C. | 08/9/2014 |
| acute abrogation of HCN1-FLNa interaction in neurons, with the use of decoy peptides that mimic the FLNa-binding domain of HCN1, abolishes the punctate distribution of HCN1 channels in neuronal cell bodies | Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons.
Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ., Free PMC Article | 04/26/2014 |
| Studies suggest that HCN1 channels may be therapeutic targets for treatment of depressive disorders. | HCN1 channels: a new therapeutic target for depressive disorders?
Shah MM. | 03/9/2013 |
| Wild-type presynaptic HCN1 channel function is persistently decreased following seizures. | TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.
Huang Z, Lujan R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM., Free PMC Article | 01/5/2013 |
| HCN1 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures. | Hyperpolarization-activated cation current contributes to spontaneous network activity in developing neocortical cultures.
Klueva J, Lima AD, Meis S, Voigt T, Munsch T. | 09/22/2012 |
| Hyperpolarization-activated currents are smaller and slower, input resistances are higher, and membrane time constants are longer in HCN1-deficient than in HCN1-expressing neurons of the ventral cochlear nucleus. | The magnitudes of hyperpolarization-activated and low-voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus.
Cao XJ, Oertel D., Free PMC Article | 03/31/2012 |
| Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2, HCN3 and HCN4. | Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.
Tu E, Waterhouse L, Duflou J, Bagnall RD, Semsarian C., Free PMC Article | 02/4/2012 |