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    IGHE immunoglobulin heavy constant epsilon [ Homo sapiens (human) ]

    Gene ID: 3497, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Shift from Cow's Milk Food Protein-Induced Enterocolitis Syndrome to IgE-Mediated Allergy: Case Series and Literature Review.

    Shift from Cow's Milk Food Protein-Induced Enterocolitis Syndrome to IgE-Mediated Allergy: Case Series and Literature Review.
    Barni S, Pessina B, Tóth V, Sarti L, Liccioli G, Tomei L, Giovannini M, Mori F.

    07/9/2024
    The Association Between Malignancy, Immunodeficiency, and Atopy in IgE-Deficient Patients.

    The Association Between Malignancy, Immunodeficiency, and Atopy in IgE-Deficient Patients.
    Agress A, Oprea Y, Roy S, Strauch C, Rosenstreich D, Ferastraoaru D.

    01/11/2024
    Patients With Asthma Only Sensitized to Staphylococcus aureus Enterotoxins Have More Exacerbations, Airflow Limitation, and Higher Levels of Sputum IL-5 and IgE.

    Patients With Asthma Only Sensitized to Staphylococcus aureus Enterotoxins Have More Exacerbations, Airflow Limitation, and Higher Levels of Sputum IL-5 and IgE.
    Schleich F, Moermans C, Gerday S, Ziant S, Louis G, Bougard N, Paulus V, Guissard F, Henket M, Bachert C, Louis R.

    11/8/2023
    Differentially expressed microRNAs in peripheral blood cell are associated with downregulated expression of IgE in nonallergic childhood asthma.

    Differentially expressed microRNAs in peripheral blood cell are associated with downregulated expression of IgE in nonallergic childhood asthma.
    Lee JH, Wang LC, Lin YT, Yang YH, Yu HH, Hu YC, Chiang BL., Free PMC Article

    04/24/2023
    TGF-beta secreted by human umbilical cord blood-derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF-alpha and IgE.

    TGF-β secreted by human umbilical cord blood-derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF-α and IgE.
    Park HH, Lee S, Yu Y, Yoo SM, Baek SY, Jung N, Seo KW, Kang KS.

    03/19/2022
    Total serum IgE level in patients of dermatophytosis and its association with various clinical parameters.

    Total serum IgE level in patients of dermatophytosis and its association with various clinical parameters.
    Patel NH, Padhiyar JK, Singh R, Patel T.

    12/4/2021
    IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China.

    IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China.
    Li J, Li Z, Kong D, Li S, Yu Y, Li H., Free PMC Article

    02/20/2021
    Imaging the Substructures of Individual IgE Antibodies with Atomic Force Microscopy.

    Imaging the Substructures of Individual IgE Antibodies with Atomic Force Microscopy.
    Hu J, Gao M, Wang Y, Liu M, Wang J, Li J, Song Z, Chen Y, Wang Z.

    09/26/2020
    This study is the first to identify the major IgE epitope-containing area of the dog allergen Can f 1.

    Clustering of conformational IgE epitopes on the major dog allergen Can f 1.
    Curin M, Weber M, Hofer G, Apostolovic D, Keller W, Reininger R, Swoboda I, Spitzauer S, Focke-Tejkl M, van Hage M, Valenta R., Free PMC Article

    07/20/2019
    Hyper-IgE is independently associated with asthma, more severe atopy and more severe eczema during childhood and adolescence. IgE 2000 IU/L may be a tool to aid prognostication of this chronic relapsing dermatologic disease and its progression to asthma.

    Hyper IgE in Childhood Eczema and Risk of Asthma in Chinese Children.
    Ng C, Hon KL, Kung JS, Pong NH, Leung TF, Wong CK., Free PMC Article

    04/15/2017
    Asthmatic subjects with high total serum IgE show increased macrophage expression of TLR4 in induced sputum.

    Expression of toll-like receptors 2 and 4 in subjects with asthma by total serum IgE level.
    Crespo-Lessmann A, Mateus E, Vidal S, Ramos-Barbón D, Torrejón M, Giner J, Soto L, Juárez C, Plaza V., Free PMC Article

    11/5/2016
    IgE levels in the third trimester of pregnancy and cord blood are strongly related to birth outcomes of fetal growth restriction

    Serum immunoglobulin E level and its impact on the pregnancy outcome associated with fetal growth restriction: a prospective cohort study.
    Xiong F, Tong Y, Li P, Huo T, Mao M.

    02/13/2016
    IgE mediated type 1 hypersensitivity can cause increase in capillary permeability and weakened the charge barrier; hence, it could be considered as one of the causes of proteinuria in Henoch-Schonlein purpura.

    Relationship between immune parameters and organ involvement in children with Henoch-Schonlein purpura.
    Pan YX, Ye Q, Shao WX, Shang SQ, Mao JH, Zhang T, Shen HQ, Zhao N., Free PMC Article

    01/16/2016
    Sputum HMGB1 levels were higher in children with asthma than in healthy controls, and were positively related to total IgE levels.

    Sputum high mobility group box-1 in asthmatic children: a noninvasive sensitive biomarker reflecting disease status.
    Cuppari C, Manti S, Chirico V, Caruso R, Salpietro V, Giacchi V, Laganà F, Arrigo T, Salpietro C, Leonardi S.

    10/24/2015
    The results explain how initial membrane interactions of clustered IgE-Fcepsilon RI complexes lead to downstream cellular responses.

    Nanodomains in early and later phases of FcɛRI signalling.
    Holowka D, Baird B., Free PMC Article

    10/24/2015
    Allergen-specific IgE levels are related to increased HLA-G in patients with allergic rhinitis and asthma.

    Serum-soluble HLA-G is associated with specific IgE in patients with allergic rhinitis and asthma.
    Ciprandi G, Corsico A, Pisati P.

    06/27/2015
    One third of 116 symptomatic bakers showed sIgE to lupine. At least some of these sensitizations were based on crossreactivity between lupine and wheat flour.

    IgE sensitization to lupine in bakers - cross-reactivity or co-sensitization to wheat flour?
    van Kampen V, Sander I, Quirce S, Brüning T, Merget R, Raulf M.

    05/30/2015
    The majority of symptomatic peanut-allergic Austrian patients are sensitized to Ara h 2 and Ara h 6 producing elevated leveles of IgE.

    Component-resolved IgE profiles in Austrian patients with a convincing history of peanut allergy.
    Ackerbauer D, Bublin M, Radauer C, Varga EM, Hafner C, Ebner C, Szépfalusi Z, Fröschl R, Hoffmann-Sommergruber K, Eiwegger T, Breiteneder H.

    05/30/2015
    Currently, neither dose reductions nor treatment withdrawal can be recommended in patients with severe allergic asthma and long term treatment with omalizumab. [review]

    [Disease modification and duration of omalizumab treatment in patients with severe allergic asthma].
    Schreiber J, Kopp MV, Korn S, Taube C, Buhl R.

    04/4/2015
    Crystal structure of the CD23-Fc3-4 complex with different molecular-packing constraints.

    A range of Cℇ3-Cℇ4 interdomain angles in IgE Fc accommodate binding to its receptor CD23.
    Dhaliwal B, Pang MO, Yuan D, Beavil AJ, Sutton BJ., Free PMC Article

    11/8/2014
    Higher serum IgE levels were associated with adult cardiovascular disease.

    Are higher serum IgE concentrations associated with adult cardiovascular disease?
    Shiue I.

    05/31/2014
    Syntaxin-4 plays a vital role in exocytosis of IgE from plasma cells. Knock-down of syntaxin-4, but not VAMP3 dramatically reduced IgE secretion from U266 plasma cells causing it to accumulate in the cell.

    Syntaxin-4 is essential for IgE secretion by plasma cells.
    Rahman A, Decourcey J, Larbi NB, Loughran ST, Walls D, Loscher CE.

    12/7/2013
    Both IgE and chymase associate with diabetes status.

    Immunoglobulin E and mast cell proteases are potential risk factors of human pre-diabetes and diabetes mellitus.
    Wang Z, Zhang H, Shen XH, Jin KL, Ye GF, Qian L, Li B, Zhang YH, Shi GP., Free PMC Article

    09/1/2012
    Elevated levels of IgE may be a feature of steroid resistance or relapse, indicating prognostic significance in adult primary nephrotic syndrome, particularly in minimal change nephrotic syndrome.

    Elevated levels of immunoglobulin E may indicate steroid resistance or relapse in adult primary nephrotic syndrome, especially in minimal change nephrotic syndrome.
    Tan Y, Yang D, Fan J, Chen Y.

    05/26/2012
    Elevated serum IgE is associated with acute severe infusion reaction during infliximab maintenance therapy in a Crohn's disease

    Elevated serum IgE prior to acute severe infusion reaction during infliximab maintenance therapy in a Crohn's disease patient.
    Kato S, Kobayashi T, Kani K, Takabayashi H, Yamamoto R, Yakabi K.

    05/19/2012
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