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    IGHM immunoglobulin heavy constant mu [ Homo sapiens (human) ]

    Gene ID: 3507, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of IGHM polymorphisms with susceptibility to type 1 diabetes.

    Association of IGHM polymorphisms with susceptibility to type 1 diabetes.
    Ferjeni Z, Raouia F, Abida O, Penha-Gonçalves C, Masmoudi H.

    06/18/2022
    Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis.

    Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis.
    Lu Z, Gao Y., Free PMC Article

    12/25/2021
    Refractory serum immunoglobulin M elevation during anti-interleukin (IL)-1- or IL-6-targeted treatment in four patients with Schnitzler syndrome.

    Refractory serum immunoglobulin M elevation during anti-interleukin (IL)-1- or IL-6-targeted treatment in four patients with Schnitzler syndrome.
    Takimoto-Ito R, Kambe N, Kogame T, Otsuka A, Nomura T, Izawa K, Tabuchi Y, Yoshifuji H, Takeuchi Y, Kabashima K.

    11/22/2021
    Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis.

    Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis.
    Oechtering J, Schaedelin S, Benkert P, Müller S, Achtnichts L, Vehoff J, Disanto G, Findling O, Fischer-Barnicol B, Orleth A, Chan A, Pot C, Barakovic M, Rahmanzadeh R, Galbusera R, Heijnen I, Lalive PH, Wuerfel J, Subramaniam S, Aeschbacher S, Conen D, Naegelin Y, Maceski A, Meier S, Berger K, Wiendl H, Lincke T, Lieb J, Yaldizli Ö, Sinnecker T, Derfuss T, Regeniter A, Zecca C, Gobbi C, Kappos L, Granziera C, Leppert D, Kuhle J, Swiss Multiple Sclerosis Cohort Study., Free PMC Article

    11/13/2021
    Agammaglobulinemia patient carries IGHM gene deletion and the novel nonsense mutation X57331.1:g.275C>A (p.Tyr43*).

    Autosomal recessive agammaglobulinemia due to defect in μ heavy chain caused by a novel mutation in the IGHM gene.
    Silva P, Justicia A, Regueiro A, Fariña S, Couselo JM, Loidi L.

    02/10/2018
    IGHM gene polymorphism is associated with type 1 diabetes.

    Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes.
    Rolim I, Duarte N, Barata G, Costa J, Gardete-Correia L, Boavida J, Duarte R, Raposo J, Peerally Z, Catarino M, Penha-Gonçalves C., Free PMC Article

    09/16/2017
    Irrespective of subtype, Acute Lymphoblastic Leukemia with high levels of IGHM, IGLL1 and VPREB1 are arrested at the pre-B stage and correlate with good prognosis in high-risk pediatric B-cell precursor acute lymphoblastic leukemia.

    The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.
    Chen D, Zheng J, Gerasimcik N, Lagerstedt K, Sjögren H, Abrahamsson J, Fogelstrand L, Mårtensson IL., Free PMC Article

    08/12/2017
    mutational analysis in cohort of Iranian patients with congenital agammaglobulinemia

    Cohort of Iranian Patients with Congenital Agammaglobulinemia: Mutation Analysis and Novel Gene Defects.
    Abolhassani H, Vitali M, Lougaris V, Giliani S, Parvaneh N, Parvaneh L, Mirminachi B, Cheraghi T, Khazaei H, Mahdaviani SA, Kiaei F, Tavakolinia N, Mohammadi J, Negahdari B, Rezaei N, Hammarstrom L, Plebani A, Aghamohammadi A.

    12/17/2016
    Rearrangement of the immunoglobulin mu-chain gene is associated with acute myeloid leukemia.

    Rearrangement and expression of the immunoglobulin μ-chain gene in human myeloid cells.
    Huang J, Sun X, Gong X, He Z, Chen L, Qiu X, Yin CC., Free PMC Article

    08/23/2014
    Serum immunoglobulin M anti-phosphorylcholine titers provide prognostic information for risk factors in acute coronary syndrome.

    IgM-phosphorylcholine autoantibodies and outcome in acute coronary syndromes.
    Caidahl K, Hartford M, Karlsson T, Herlitz J, Pettersson K, de Faire U, Frostegård J.

    03/1/2014
    tracked the clonal history of tumor cells by studying mutations on the switch mu region of the der(14)t(14;18) during the early phase of the class-switch recombination

    S(mu) mutation patterns suggest different progression pathways in follicular lymphoma: early direct or late from FL progenitor cells.
    Ruminy P, Jardin F, Picquenot JM, Parmentier F, Contentin N, Buchonnet G, Tison S, Rainville V, Tilly H, Bastard C.

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)

    Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
    Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T.

    03/13/2008
    lower levels of B-cell receptor surface expression observed in chronic lymphocytic leukemia are accounted for by an impaired glycosylation and folding of the mu and CD79a chains.

    Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains.
    Vuillier F, Dumas G, Magnac C, Prevost MC, Lalanne AI, Oppezzo P, Melanitou E, Dighiero G, Payelle-Brogard B.

    01/21/2010
    Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone

    Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone.
    Taylor BJ, Pittman JA, Seeberger K, Mant MJ, Reiman T, Belch AR, Pilarski LM.

    01/21/2010
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