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    APP amyloid beta precursor protein [ Homo sapiens (human) ]

    Gene ID: 351, updated on 12-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The link between amyloid beta and ferroptosis pathway in Alzheimer's disease progression.

    The link between amyloid β and ferroptosis pathway in Alzheimer's disease progression.
    Majerníková N, Marmolejo-Garza A, Salinas CS, Luu MDA, Zhang Y, Trombetta-Lima M, Tomin T, Birner-Gruenberger R, Lehtonen Š, Koistinaho J, Wolters JC, Ayton S, den Dunnen WFA, Dolga AM., Free PMC Article

    11/7/2024
    Pathology of Amyloid-beta (Abeta) Peptide Peripheral Clearance in Alzheimer's Disease.

    Pathology of Amyloid-β (Aβ) Peptide Peripheral Clearance in Alzheimer's Disease.
    Tsoy A, Umbayev B, Kassenova A, Kaupbayeva B, Askarova S., Free PMC Article

    11/5/2024
    Unveiling the effect of CaCl2 on amyloid beta aggregation via supercritical angle Raman and fluorescence spectroscopy and microscopy.

    Unveiling the effect of CaCl(2) on amyloid β aggregation via supercritical angle Raman and fluorescence spectroscopy and microscopy.
    Münch NS, Das S, Seeger S., Free PMC Article

    10/31/2024
    Secondary Nucleation of Abeta Revealed by Single-Molecule and Computational Approaches.

    Secondary Nucleation of Aβ Revealed by Single-Molecule and Computational Approaches.
    Meyer N, Arroyo N, Roustan L, Janot JM, Charles-Achille S, Torrent J, Picaud F, Balme S., Free PMC Article

    10/31/2024
    Cellular prion protein acts as mediator of amyloid beta uptake by caveolin-1 causing cellular dysfunctions in vitro and in vivo.

    Cellular prion protein acts as mediator of amyloid beta uptake by caveolin-1 causing cellular dysfunctions in vitro and in vivo.
    da Silva Correia A, Schmitz M, Fischer AL, da Silva Correia S, Simonetti FL, Saher G, Goya-Maldonado R, Arora AS, Fischer A, Outeiro TF, Zerr I., Free PMC Article

    10/28/2024
    Structural Insight into Melatonin's Influence on the Conformation of Abeta42 Dimer Studied by Molecular Dynamics Simulation.

    Structural Insight into Melatonin's Influence on the Conformation of Aβ(42) Dimer Studied by Molecular Dynamics Simulation.
    Kang W, Lu Y, Etaka JC, Salsbury FR Jr, Derreumaux P.

    10/28/2024
    Decreased extrasynaptic delta-GABAA receptors in PNN-associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease.

    Decreased extrasynaptic δ-GABA(A) receptors in PNN-associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease.
    Zhang W, Liu T, Li J, Singh J, Chan A, Islam A, Petrache A, Peng Y, Harvey K, Ali AB.

    10/18/2024
    Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology.

    Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology.
    Goettemoeller AM, Banks E, Kumar P, Olah VJ, McCann KE, South K, Ramelow CC, Eaton A, Duong DM, Seyfried NT, Weinshenker D, Rangaraju S, Rowan MJM., Free PMC Article

    09/18/2024
    Elevated concentrations of amyloid-beta oligomers and their proapoptotic effects on age-related cataract.

    Elevated concentrations of amyloid-β oligomers and their proapoptotic effects on age-related cataract.
    Lin P, Xu J, Yang F, Li D, Zhang R, Jiang Y, Zheng T.

    09/17/2024
    Are Women with Polycystic Ovary Syndrome at Increased Risk of Alzheimer Disease? Lessons from Insulin Resistance, Tryptophan and Gonadotropin Disturbances and Their Link with Amyloid-Beta Aggregation.

    Are Women with Polycystic Ovary Syndrome at Increased Risk of Alzheimer Disease? Lessons from Insulin Resistance, Tryptophan and Gonadotropin Disturbances and Their Link with Amyloid-Beta Aggregation.
    Sobczuk J, Paczkowska K, Andrusiów S, Bolanowski M, Daroszewski J., Free PMC Article

    09/11/2024
    Interplay between glypican-1, amyloid-beta and tau phosphorylation in human neural stem cells.

    Interplay between glypican-1, amyloid-β and tau phosphorylation in human neural stem cells.
    Cheng F, Fransson LÅ, Mani K.

    09/9/2024
    Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.

    Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
    Rajani RM, Ellingford R, Hellmuth M, Harris SS, Taso OS, Graykowski D, Lam FKW, Arber C, Fertan E, Danial JSH, Swire M, Lloyd M, Giovannucci TA, Bourdenx M, Klenerman D, Vassar R, Wray S, Sala Frigerio C, Busche MA., Free PMC Article

    08/23/2024
    Amyloid-beta misfolding and GFAP predict risk of clinical Alzheimer's disease diagnosis within 17 years.

    Amyloid-beta misfolding and GFAP predict risk of clinical Alzheimer's disease diagnosis within 17 years.
    Beyer L, Stocker H, Rujescu D, Holleczek B, Stockmann J, Nabers A, Brenner H, Gerwert K.

    08/13/2024
    G-protein coupled estrogen receptor 1, amyloid-beta, and tau tangles in older adults.

    G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults.
    Oveisgharan S, Yu L, de Paiva Lopes K, Petyuk VA, Tasaki S, Vialle R, Menon V, Wang Y, De Jager PL, Schneider JA, Bennett DA., Free PMC Article

    08/8/2024
    Mitofusin 1 and 2 overexpression reduces AbetaO-mediated ER stress and apoptosis in N2a APPswe cells.

    Mitofusin 1 and 2 overexpression reduces AβO-mediated ER stress and apoptosis in N2a APPswe cells.
    Kam MK, Jung SM, Lee GE, Lee SW, Lee HJ, Park YH, Lee DS.

    08/6/2024
    Consequences of Amyloid-beta Deficiency for the Liver.

    Consequences of Amyloid-β Deficiency for the Liver.
    Buniatian GH, Schwinghammer U, Tremmel R, Cynis H, Weiss TS, Weiskirchen R, Lauschke VM, Youhanna S, Ramos I, Valcarcel M, Seferyan T, Rahfeld JU, Rieckmann V, Klein K, Buadze M, Weber V, Kolak V, Gebhardt R, Friedman SL, Müller UC, Schwab M, Danielyan L., Free PMC Article

    07/31/2024
    Amyloid beta protein negatively regulates human platelet activation induced by thrombin receptor-activating protein.

    Amyloid β protein negatively regulates human platelet activation induced by thrombin receptor-activating protein.
    Mizutani D, Tokuda H, Onuma T, Uematsu K, Nakashima D, Ueda K, Doi T, Enomoto Y, Matsushima-Nishiwaki R, Ogura S, Iida H, Kozawa O, Iwama T.

    07/28/2024
    CryoET of beta-amyloid and tau within postmortem Alzheimer's disease brain.

    CryoET of β-amyloid and tau within postmortem Alzheimer's disease brain.
    Gilbert MAG, Fatima N, Jenkins J, O'Sullivan TJ, Schertel A, Halfon Y, Wilkinson M, Morrema THJ, Geibel M, Read RJ, Ranson NA, Radford SE, Hoozemans JJM, Frank RAW., Free PMC Article

    07/26/2024
    Modulation of Alzheimer's Disease Abeta40 Fibril Polymorphism by the Small Heat Shock Protein alphaB-Crystallin.

    Modulation of Alzheimer's Disease Aβ40 Fibril Polymorphism by the Small Heat Shock Protein αB-Crystallin.
    Rodina N, Hornung S, Sarkar R, Suladze S, Peters C, Schmid PWN, Niu Z, Haslbeck M, Buchner J, Kapurniotu A, Reif B., Free PMC Article

    07/22/2024
    The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Abeta43 and atypical clinical manifestations.

    The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations.
    Arber C, Belder CRS, Tomczuk F, Gabriele R, Buhidma Y, Farrell C, O'Connor A, Rice H, Lashley T, Fox NC, Ryan NS, Wray S., Free PMC Article

    07/22/2024
    Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAbeta-KI) mice.

    Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice.
    Dunham SJB, Avelar-Barragan J, Rothman JA, Adams ED, Faraci G, Forner S, Kawauchi S, Tenner AJ, Green KN, LaFerla FM, MacGregor GR, Mapstone M, Whiteson KL., Free PMC Article

    07/22/2024
    CNTN4 modulates neural elongation through interplay with APP.

    CNTN4 modulates neural elongation through interplay with APP.
    Bamford RA, Zuko A, Eve M, Sprengers JJ, Post H, Taggenbrock RLRE, Fäβler D, Mehr A, Jones OJR, Kudzinskas A, Gandawijaya J, Müller UC, Kas MJH, Burbach JPH, Oguro-Ando A., Free PMC Article

    07/8/2024
    Distinctive contribution of two additional residues in protein aggregation of Abeta42 and Abeta40 isoforms.

    Distinctive contribution of two additional residues in protein aggregation of Aβ42 and Aβ40 isoforms.
    Im D, Choi TS., Free PMC Article

    07/5/2024
    The Co-oligomers of Abeta42 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level.

    The Co-oligomers of Aβ42 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level.
    Deng J, Liu B, Tao Q, Luo Y, Zhu Y, Huang X, Yue F.

    07/5/2024
    Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer's disease.

    Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer's disease.
    Ollen-Bittle N, Pejhan S, Pasternak SH, Keene CD, Zhang Q, Whitehead SN.

    06/28/2024
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