| Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis. | Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis.
O'Sullivan ED, Mylonas KJ, Xin C, Baird DP, Carvalho C, Docherty MH, Campbell R, Matchett KP, Waddell SH, Walker AD, Gallagher KM, Jia S, Leung S, Laird A, Wilflingseder J, Willi M, Reck M, Finnie S, Pisco A, Gordon-Keylock S, Medvinsky A, Boulter L, Henderson NC, Kirschner K, Chandra T, Conway BR, Hughes J, Denby L, Bonventre JV, Ferenbach DA. | 10/20/2023 |
| Acrocapitofemoral dysplasia: Novel mutation in IHH in two adult patients from the third family in the literature and progression of the disease. | Acrocapitofemoral dysplasia: Novel mutation in IHH in two adult patients from the third family in the literature and progression of the disease.
Ozyavuz Cubuk P, Duz MB. | 01/15/2022 |
| Highly Conserved C-Terminal Region of Indian Hedgehog N-Fragment Contributes to Its Auto-Processing and Multimer Formation. | Highly Conserved C-Terminal Region of Indian Hedgehog N-Fragment Contributes to Its Auto-Processing and Multimer Formation.
Wang X, Liu H, Liu Y, Han G, Wang Y, Chen H, He L, Ma G., Free PMC Article | 09/25/2021 |
| Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway. | Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.
Al-Azab M, Wang B, Elkhider A, Walana W, Li W, Yuan B, Ye Y, Tang Y, Almoiliqy M, Adlat S, Wei J, Zhang Y, Li X., Free PMC Article | 05/15/2021 |
| Clinical and Molecular Description of 16 Families With Heterozygous IHH Variants. | Clinical and Molecular Description of 16 Families With Heterozygous IHH Variants.
Sentchordi-Montané L, Benito-Sanz S, Aza-Carmona M, Pereda A, Parrón-Pajares M, de la Torre C, Vasques GA, Funari MFA, Travessa AM, Dias P, Suarez-Ortega L, González-Buitrago J, Portillo-Najera NE, Llano-Rivas I, Martín-Frías M, Ramírez-Fernández J, Sánchez Del Pozo J, Garzón-Lorenzo L, Martos-Moreno GA, Alfaro-Iznaola C, Mulero-Collantes I, Ruiz-Ocaña P, Casano-Sancho P, Portela A, Ruiz-Pérez L, Del Pozo A, Vallespín E, Solís M, Lerario AM, González-Casado I, Ros-Pérez P, Pérez de Nanclares G, Jorge AAL, Heath KE. | 02/13/2021 |
| HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells. | HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.
Arasu UT, Deen AJ, Pasonen-Seppänen S, Heikkinen S, Lalowski M, Kärnä R, Härkönen K, Mäkinen P, Lázaro-Ibáñez E, Siljander PR, Oikari S, Levonen AL, Rilla K., Free PMC Article | 10/24/2020 |
| the levels of SHH and IHH proteins were significantly correlated with the expression of proteins involved in the TGF-b1 pathway. Moreover, the expression of the HH pathway ligands was positively associated with the expression of TAZ, supporting the notion that TAZ may play a role in the activation of the HH pathway thereby regulating the expression of its ligands | Downregulation of hedgehog ligands in human simple steatosis may protect against nonalcoholic steatohepatitis: Is TAZ a crucial regulator?
Khajehahmadi Z, Mohagheghi S, Nikeghbalian S, Geramizadeh B, Khodadadi I, Karimi J, Ghaffari ME, Tavilani H. | 05/16/2020 |
| Report of a five-generation Chinese family with Brachydactyly type A1 (BDA-1) due to a novel pathogenic variant (c.299A > G (p.D100G)) of IHH; this expands the clinical and genetic spectrum of BDA-1. | A novel variant of IHH in a Chinese family with brachydactyly type 1.
Yang Q, Wang J, Tian X, Shen F, Lan J, Zhang Q, Fan X, Yi S, Li M, Shen Y., Free PMC Article | 05/9/2020 |
| The Roles of Indian Hedgehog Signaling in TMJ Formation. | The Roles of Indian Hedgehog Signaling in TMJ Formation.
Bechtold TE, Kurio N, Nah HD, Saunders C, Billings PC, Koyama E., Free PMC Article | 05/2/2020 |
| pathogenesis of BDA1 and the role of IHH signaling in chondrogenesis | p.E95K mutation in Indian hedgehog causing brachydactyly type A1 impairs IHH/Gli1 downstream transcriptional regulation.
Shen L, Ma G, Shi Y, Ruan Y, Yang X, Wu X, Xiong Y, Wan C, Yang C, Cai L, Xiong L, Gong X, He L, Qin S., Free PMC Article | 01/11/2020 |
| Ihh is a marker for poor prognosis in patients with lung squamous cell carcinoma and adenocarcinoma. WIF-1 is not a predictive marker for lung cancer. | WIF-1 and Ihh Expression and Clinical Significance in Patients With Lung Squamous Cell Carcinoma and Adenocarcinoma.
Zhang Y, Hu C. | 07/27/2019 |
| Inhibition of EZH2 resulted in de-repression of IHH, decreased self-renewal, and increased sensitivity to chemotherapy in vivo. | Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.
Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, Carvalho DD, Lupien M, Arrowsmith CH, O'Brien CA., Free PMC Article | 05/4/2019 |
| Downregulation of indian hedgehog is associated with Celiac Disease. | Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation.
Senger S, Sapone A, Fiorentino MR, Mazzarella G, Lauwers GY, Fasano A., Free PMC Article | 02/2/2019 |
| TL1A modulated Rheumatoid arthritis-fibroblast-like synoviocytes migration and Indian hedgehog signaling pathway using TNFR2. | TL1A mediates fibroblast-like synoviocytes migration and Indian Hedgehog signaling pathway via TNFR2 in patients with rheumatoid arthritis.
Al-Azab M, Wei J, Ouyang X, Elkhider A, Walana W, Sun X, Tang Y, Wang B, Li X. | 09/29/2018 |
| Association of pathogenic variants in IHH with short stature with nonspecific skeletal abnormalities and a frequent cause of growth disorder, with a preliminary good response to rhGH. | IHH Gene Mutations Causing Short Stature With Nonspecific Skeletal Abnormalities and Response to Growth Hormone Therapy.
Vasques GA, Funari MFA, Ferreira FM, Aza-Carmona M, Sentchordi-Montané L, Barraza-García J, Lerario AM, Yamamoto GL, Naslavsky MS, Duarte YAO, Bertola DR, Heath KE, Jorge AAL. | 05/26/2018 |
| Studies suggest significance of other signaling aside from hedgehog in the pathogenesis of basal cell carcinoma (BCC) of the skin. | Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.
Bakshi A, Chaudhary SC, Rana M, Elmets CA, Athar M., Free PMC Article | 12/9/2017 |
| Gorlin syndrome-derived induced pluripotent stem cells (iPSCs) expressed lower basal levels than control iPSCs of the genes encoding the Hh ligands Indian Hedgehog (IHH) and Sonic Hedgehog (SHH). | Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.
Hasegawa D, Ochiai-Shino H, Onodera S, Nakamura T, Saito A, Onda T, Watanabe K, Nishimura K, Ohtaka M, Nakanishi M, Kosaki K, Yamaguchi A, Shibahara T, Azuma T., Free PMC Article | 11/18/2017 |
| Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors. | Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.
Dagklis A, Demeyer S, De Bie J, Radaelli E, Pauwels D, Degryse S, Gielen O, Vicente C, Vandepoel R, Geerdens E, Uyttebroeck A, Boeckx N, de Bock CE, Cools J. | 08/5/2017 |
| CLIC4 and Ihh could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma. | Association of chloride intracellular channel 4 and Indian hedgehog proteins with survival of patients with pancreatic ductal adenocarcinoma.
Zou Q, Yang Z, Li D, Liu Z, Yuan Y., Free PMC Article | 07/8/2017 |
| The serum levels of IHH and SHH were significantly higher in autistic subjects than those of control subjects. The findings support a correlation between SHH, IHH and BDNF in autistic children, suggesting their pathological role in autism. | Correlation Between Hedgehog (Hh) Protein Family and Brain-Derived Neurotrophic Factor (BDNF) in Autism Spectrum Disorder (ASD).
Halepoto DM, Bashir S, Zeina R, Al-Ayadhi LY. | 11/5/2016 |
| Our results show for the first time that Indian hedgehog does not cause extracellular matrix degradation in healthy ex vivo cartilage or in the presence of IL-1beta | Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.
Thompson CL, Patel R, Kelly TA, Wann AK, Hung CT, Chapple JP, Knight MM., Free PMC Article | 09/10/2016 |
| The Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway. | The Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway.
Yi J, Zhu Y, Jia Y, Jiang H, Zheng X, Liu D, Gao S, Sun M, Hu B, Jiao B, Wang L, Wang K., Free PMC Article | 08/6/2016 |
| Studies indicate that the hedgehog (Hh) signaling pathway has become one of the most studied potential therapeutic targets in hematological malignancies. | New insight into hedgehog signaling in hematological malignancies.
Geng L, Wang X. | 04/9/2016 |
| Findings demonstrated that Ihh promotes human cartilage endplate degeneration. | Indian hedgehog contributes to human cartilage endplate degeneration.
Wang S, Yang K, Chen S, Wang J, Du G, Fan S, Wei L. | 02/20/2016 |
| endogenously produced IHH is playing a critical role in regulating hBMSC chondrogenesis. | Endogenously produced Indian Hedgehog regulates TGFβ-driven chondrogenesis of human bone marrow stromal/stem cells.
Handorf AM, Chamberlain CS, Li WJ. | 12/26/2015 |