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    IL4R interleukin 4 receptor [ Homo sapiens (human) ]

    Gene ID: 3566, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of IL4RA and IL-8 polymorphism in predicting susceptibility to tuberculosis.

    Association of IL4RA and IL-8 polymorphism in predicting susceptibility to tuberculosis.
    K J, Joshi JL, Kansal H, Chopra V, Garg K, Girdhar N, Sharma K, Deshwal R, Sharma S.

    09/25/2024
    Type II Interleukin-4 Receptor Activation in Basal Breast Cancer Cells Promotes Tumor Progression via Metabolic and Epigenetic Modulation.

    Type II Interleukin-4 Receptor Activation in Basal Breast Cancer Cells Promotes Tumor Progression via Metabolic and Epigenetic Modulation.
    Williams D, Hargrove-Wiley E, Bindeman W, Valent D, Miranda AX, Beckstead J, Fingleton B., Free PMC Article

    06/7/2024
    Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients.

    Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients.
    Al-Saffar OB, Ad'hiah AH.

    06/5/2024
    Global IL4Ralpha blockade exacerbates heart failure after an ischemic event in mice and humans.

    Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans.
    Alvarez-Argote S, Almeida VA, Knas MC, Buday SL, Patterson M, O'Meara CC.,

    04/18/2024
    Th2 cytokine signaling through IL-4Ralpha increases eotaxin-3 secretion and tension in human esophageal smooth muscle.

    Th2 cytokine signaling through IL-4Rα increases eotaxin-3 secretion and tension in human esophageal smooth muscle.
    Nelson MR, Zhang X, Podgaetz E, Wang X, Zhang Q, Pan Z, Spechler SJ, Souza RF.

    12/28/2023
    Association of IL4RA polymorphism in predicting susceptibility toward chronic obstructive pulmonary disease.

    Association of IL4RA polymorphism in predicting susceptibility toward chronic obstructive pulmonary disease.
    Pandit D, Sharma P, Yadav H, Garg K, Chopra V, Sharma S.

    09/18/2023
    Association of the IL-4R Q576R Polymorphism with Pediatric Asthma: a meta-analysis.

    Association of the IL-4R Q576R Polymorphism with Pediatric Asthma: a meta-analysis.
    Chen X, Hu J, Li K, Liu S, Ye Q, Cao B., Free PMC Article

    08/9/2023
    Prognosis value and positive association of Rab1A/IL4Ralpha aberrant expression in gastric cancer.

    Prognosis value and positive association of Rab1A/IL4Rα aberrant expression in gastric cancer.
    Li H, Cheng Z, Jiang B, Shao X, Xu M., Free PMC Article

    05/3/2023
    IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.

    IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
    Aranda CJ, Gonzalez-Kozlova E, Saunders SP, Fernandes-Braga W, Ota M, Narayanan S, He JS, Del Duca E, Swaroop B, Gnjatic S, Shattner G, Reibman J, Soter NA, Guttman-Yassky E, Curotto de Lafaille MA., Free PMC Article

    03/6/2023
    Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis.

    Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis.
    Avlas S, Shani G, Rhone N, Itan M, Dolitzky A, Hazut I, Grisaru-Tal S, Gordon Y, Shoda T, Ballaban A, Ben-Baruch NM, Rochman M, Diesendruck Y, Nahary L, Bitton A, Halpern Z, Benhar I, Varol C, Rothenberg ME, Munitz A., Free PMC Article

    02/4/2023
    Atopic Dermatitis Mediates the Association Between an IL4RA Variant and Food Allergy in School-Aged Children.

    Atopic Dermatitis Mediates the Association Between an IL4RA Variant and Food Allergy in School-Aged Children.
    Banzon TM, Kelly MS, Bartnikas LM, Sheehan WJ, Cunningham A, Harb H, Crestani E, Valeri L, Greco KF, Chatila TA, Phipatanakul W, Lai PS., Free PMC Article

    08/20/2022
    CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.

    CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.
    Jiang T, Wang H, Liu L, Song H, Zhang Y, Wang J, Liu L, Xu T, Fan R, Xu Y, Wang S, Shi L, Zheng L, Wang R, Song J., Free PMC Article

    03/26/2022
    Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer.

    Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer.
    Huang T, Chen B, Wang F, Cai W, Wang X, Huang B, Liu F, Jiang B, Zhang Y.

    01/8/2022
    Associations of interleukin-4 and interleukin-4 receptor loci with esophageal squamous cell carcinoma susceptibility.

    Associations of interleukin-4 and interleukin-4 receptor loci with esophageal squamous cell carcinoma susceptibility.
    Wang J, Chen T, Tang W, Kang M, Chen S.

    01/8/2022
    GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals.

    GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals.
    Shido K, Kojima K, Shirota M, Yamasaki K, Motoike IN, Hozawa A, Ogishima S, Minegishi N, Tanno K, Katsuoka F, Tamiya G, Aiba S, Yamamoto M, Kinoshita K.

    12/11/2021
    M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages.

    M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages.
    Gunassekaran GR, Poongkavithai Vadevoo SM, Baek MC, Lee B.

    12/11/2021
    Expression of IL4Ralpha and IL13Ralpha1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum.

    Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum.
    Kim KM, Hussein UK, Park SH, Moon YJ, Zhang Z, Ahmed AG, Ahn AR, Park HS, Kim JR, Jang KY., Free PMC Article

    11/6/2021
    Interrupting reactivation of immunologic memory diverts the allergic response and prevents anaphylaxis.

    Interrupting reactivation of immunologic memory diverts the allergic response and prevents anaphylaxis.
    Bruton K, Spill P, Vohra S, Baribeau O, Manzoor S, Gadkar S, Davidson M, Walker TD, Koenig JFE, Ellenbogen Y, Florescu A, Wen J, Chu DK, Waserman S, Jiménez-Saiz R, Epelman S, Robbins C, Jordana M.

    09/25/2021
    Interleukin 4 and Interleukin 4 receptor alpha gene variants and risk of atopy - A case control study based assessment.

    Interleukin 4 and Interleukin 4 receptor alpha gene variants and risk of atopy - A case control study based assessment.
    Qurashi TA, Bhat GA, Khan MS, Rasool R, Sameen F, Hassan I, Mudassar S.

    09/18/2021
    Immunohistochemical Characterization of the IL-13:IL-4 Receptor alpha Axis in the Skin of Adult Patients with Moderate to Severe Atopic Dermatitis and Healthy Controls.

    Immunohistochemical Characterization of the IL-13:IL-4 Receptor α Axis in the Skin of Adult Patients with Moderate to Severe Atopic Dermatitis and Healthy Controls.
    Miranda E, Roberts J, Novick S, Lapointe JM, Bruijnzeel-Koomen C, Thijs J, Sleeman MA, May RD, Hijnen D, Strickland I.

    09/18/2021
    Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children.

    Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children.
    Elsaid A, Shoaib RMS, Badr SS, Wahba Y, Ayyad SN.

    08/7/2021
    Polymorphisms of IL-4 and IL-4R are associated to some demographic characteristics of differentiated thyroid cancer patients but are not determinants of risk in the Brazilian population.

    Polymorphisms of IL-4 and IL-4R are associated to some demographic characteristics of differentiated thyroid cancer patients but are not determinants of risk in the Brazilian population.
    Martins MB, de Assis Batista F, Bufalo NE, Peres KC, Meneghetti M, da Assumpção LVM, Ward LS.

    07/17/2021
    Blockade of IL-4Ralpha inhibits group 2 innate lymphoid cell responses in asthma patients.

    Blockade of IL-4Rα inhibits group 2 innate lymphoid cell responses in asthma patients.
    Patel G, Pan J, Ye L, Shen X, Rosloff D, D'Souza SS, Fung ITH, Celstin J, Sun W, Sankar P, Zhang Y, Pasha MA, Yang Q., Free PMC Article

    06/12/2021
    Detection of association of IL1beta, IL4R, and IL6 gene polymorphisms with cervical cancer in the Bangladeshi women by tetra-primer ARMS-PCR method.

    Detection of association of IL1β, IL4R, and IL6 gene polymorphisms with cervical cancer in the Bangladeshi women by tetra-primer ARMS-PCR method.
    Muhammad SB, Hassan F, Bhowmik KK, Millat MS, Sarwar MS, Aziz MA, Barek MA, Sarowar Uddin M, Ferdous M, Safiqul Islam M.

    05/29/2021
    Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.

    Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.
    Shi J, Song X, Traub B, Luxenhofer M, Kornmann M., Free PMC Article

    04/24/2021
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