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    CXCR2 C-X-C motif chemokine receptor 2 [ Homo sapiens (human) ]

    Gene ID: 3579, updated on 1-Jul-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.

    CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.
    Xiong G, Chen Z, Liu Q, Peng F, Zhang C, Cheng M, Ling R, Chen S, Liang Y, Chen D, Zhou Q., Free PMC Article

    06/26/2024
    CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in the Formation and Progression of RCC with Inferior Vena Cava Tumour Thrombus.

    CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in the Formation and Progression of RCC with Inferior Vena Cava Tumour Thrombus.
    Wang L, Gao J, Zheng S, Luo Z, Xu Z, Che H, Wang Z.

    05/9/2024
    VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.

    VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.
    Sarker P, Pereira GMV, Khullar V, Yu J, Cartwright R., Free PMC Article

    05/7/2024
    CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.

    CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.
    Yin C, Liu B, Dong Z, Shi S, Peng C, Pan Y, Bi X, Nie H, Zhang Y, Tai Y, Hu Q, Wang X, Shao X, An H, Fang J, Wang C, Liu B., Free PMC Article

    04/22/2024
    Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-kappaB signaling in diabetic kidney disease.

    Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease.
    Cui S, Chen X, Li J, Wang W, Meng D, Zhu S, Shen S., Free PMC Article

    04/5/2024
    Inhibition of chemokine receptor CXCR2 attenuates postoperative peritoneal adhesion formation.

    Inhibition of chemokine receptor CXCR2 attenuates postoperative peritoneal adhesion formation.
    Su S, Hou C, Tang Q.

    03/19/2024
    Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis.

    Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis.
    Ma GB, Chen WX, Zhan FJ, Xie WJ, Chen RW, Chen H, Ye WL, Jiang Y, Xu JP.

    11/13/2023
    IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation.

    IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation.
    Meng ZW, Zhang L, Cai XR, Wang X, She FF, Chen YL., Free PMC Article

    11/3/2023
    CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A.

    CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A.
    La Cognata V, D'Amico AG, Maugeri G, Morello G, Guarnaccia M, Magrì B, Aronica E, D'Agata V, Cavallaro S., Free PMC Article

    08/14/2023
    IL8 derived from macrophages inhibits CD8[+] T-cell function by downregulating TIM3 expression through IL8-CXCR2 axis in patients with advanced colorectal cancer.

    IL8 derived from macrophages inhibits CD8(+) T-cell function by downregulating TIM3 expression through IL8-CXCR2 axis in patients with advanced colorectal cancer.
    Zhao C, Wang D, Li Z, Zhang Z, Xu Y, Liu J, Lei Q, Han D, Huo Y, Liu S, Li L, Zhang Y.

    07/27/2023
    IL-8-induced CXCR2 down-regulation in circulating monocytes in hepatocellular carcinoma is partially dependent on MAGL.

    IL-8-induced CXCR2 down-regulation in circulating monocytes in hepatocellular carcinoma is partially dependent on MAGL.
    Liu CZ, Liu XB, Sun J, Yu CQ, Yao JC, Liu Z, Hao JC., Free PMC Article

    07/7/2023
    Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2.

    Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2.
    Cai H, Chen Y, Chen X, Sun W, Li Y.

    02/25/2023
    Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19.

    Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19.
    Rice CM, Lewis P, Ponce-Garcia FM, Gibbs W, Groves S, Cela D, Hamilton F, Arnold D, Hyams C, Oliver E, Barr R, Goenka A, Davidson A, Wooldridge L, Finn A, Rivino L, Amulic B., Free PMC Article

    01/14/2023
    CXC- receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain.

    CXC- receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain.
    Qiu C, Wang C, Sun X, Xu J, Wu J, Zhang R, Li G, Xue K, Zhang X, Qian S., Free PMC Article

    12/10/2022
    Analysis of the concentration of CXCL8 chemokine and its CXCR1 and CXCR2 receptors in peritoneal fluid of women with endometriosis.

    Analysis of the concentration of CXCL8 chemokine and its CXCR1 and CXCR2 receptors in peritoneal fluid of women with endometriosis.
    Smycz-Kubańska M, Mamrocha A, Wendlocha D, Królewska-Daszczyńska P, Strzelec A, Stępień S, Mielczarek-Palacz A.

    10/1/2022
    PDCD10 promotes the aggressive behaviors of pituitary adenomas by up-regulating CXCR2 and activating downstream AKT/ERK signaling.

    PDCD10 promotes the aggressive behaviors of pituitary adenomas by up-regulating CXCR2 and activating downstream AKT/ERK signaling.
    Liu J, Wang J, Tian W, Xu Y, Li R, Zhao K, You C, Zhu Y, Bartsch JW, Niu H, Zhang H, Shu K, Lei T., Free PMC Article

    08/27/2022
    Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance.

    Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance.
    Smycz-Kubańska M, Stępień S, Gola JM, Kruszniewska-Rajs C, Wendlocha D, Królewska-Daszczyńska P, Strzelec A, Strzelczyk J, Szanecki W, Witek A, Mielczarek-Palacz A., Free PMC Article

    08/20/2022
    Neutrophil Infiltration Characterized by Upregulation of S100A8, S100A9, S100A12 and CXCR2 Is Associated With the Co-Occurrence of Crohn's Disease and Peripheral Artery Disease.

    Neutrophil Infiltration Characterized by Upregulation of S100A8, S100A9, S100A12 and CXCR2 Is Associated With the Co-Occurrence of Crohn's Disease and Peripheral Artery Disease.
    Yao Z, Zhang B, Niu G, Yan Z, Tong X, Zou Y, Li Y, Yang M., Free PMC Article

    07/23/2022
    Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro.

    Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro.
    Wang H, Huang Q, Zhang Z, Ji J, Sun T, Wang D., Free PMC Article

    07/9/2022
    Association between IL8RB C1208T mutation and risk of cancer: A pooled analysis based on 5299 cases and 6899 controls.

    Association between IL8RB C1208T mutation and risk of cancer: A pooled analysis based on 5299 cases and 6899 controls.
    Sun HY, Min ZC, Gao L, Zhang ZY, Pang TL, Gao YJ, Pan H, Ou-Yang J., Free PMC Article

    05/21/2022
    CXCR2 signaling might have a tumor-suppressive role in patients with cholangiocarcinoma.

    CXCR2 signaling might have a tumor-suppressive role in patients with cholangiocarcinoma.
    Yamamoto Y, Sugimoto A, Maruo K, Tsujio G, Sera T, Kushiyama S, Nishimura S, Kuroda K, Togano S, Eguchi S, Tanaka R, Kimura K, Amano R, Ohira M, Yashiro M., Free PMC Article

    04/30/2022
    CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer.

    CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer.
    Korbecki J, Kupnicka P, Chlubek M, Gorący J, Gutowska I, Baranowska-Bosiacka I., Free PMC Article

    04/16/2022
    Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma.

    Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma.
    Schoetz U, Klein D, Hess J, Shnayien S, Spoerl S, Orth M, Mutlu S, Hennel R, Sieber A, Ganswindt U, Luka B, Thomsen AR, Unger K, Jendrossek V, Zitzelsberger H, Blüthgen N, Belka C, Unkel S, Klinger B, Lauber K., Free PMC Article

    04/16/2022
    Morphoproteomics Identifies SIRT1, EZH2 and CXCR4 Pathways in Diffuse Large B-Cell Lymphoma: Therapeutic Implications.

    Morphoproteomics Identifies SIRT1, EZH2 and CXCR4 Pathways in Diffuse Large B-Cell Lymphoma: Therapeutic Implications.
    Brown RE, Zhang S, Wang XI.

    04/9/2022
    Biallelic CXCR2 loss-of-function mutations define a distinct congenital neutropenia entity.

    Biallelic CXCR2 loss-of-function mutations define a distinct congenital neutropenia entity.
    Marin-Esteban V, Youn J, Beaupain B, Jaracz-Ros A, Barlogis V, Fenneteau O, Leblanc T, Bellanger F, Pellet P, Buratti J, Lapillonne H, Bachelerie F, Donadieu J, Bellanné-Chantelot C., Free PMC Article

    04/9/2022
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