| Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer. | Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer.
Shi J, Shen X, Kang Q, Yang X, Denzinger M, Kornmann M, Traub B., Free PMC Article | 04/30/2022 |
| Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease. | Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.
Hussein MS, El-Barbary AM, Nada DW, Gaber RA, Elkolaly RM, Aboelhawa MA. | 11/13/2021 |
| IL-13 and IL-13Ralpha1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation. | IL-13 and IL-13Rα1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation.
Zhang Y, Li C, Zhang M, Li Z. | 01/5/2019 |
| High IL13RA1 expression is associated with Invasive breast Cancer. | Elevated Interleukin-13 Receptor Alpha 1 Expression in Tumor Cells Is Associated with Poor Prognosis in Patients with Invasive Breast Cancer.
Park MH, Kwon HJ, Kim JR, Lee B, Lee SJ, Bae YK. | 08/4/2018 |
| in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. | New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.
Amit U, Kain D, Wagner A, Sahu A, Nevo-Caspi Y, Gonen N, Molotski N, Konfino T, Landa N, Naftali-Shani N, Blum G, Merquiol E, Karo-Atar D, Kanfi Y, Paret G, Munitz A, Cohen HY, Ruppin E, Hannenhalli S, Leor J., Free PMC Article | 04/21/2018 |
| IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells | IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells.
Cao H, Zhang J, Liu H, Wan L, Zhang H, Huang Q, Xu E, Lai M., Free PMC Article | 03/31/2018 |
| sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism. | Soluble interleukin-13rα1: a circulating regulator of glucose.
Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT., Free PMC Article | 12/23/2017 |
| these data suggest that microRNA-143 suppresses IL-13 activity and inflammation through targeting of IL-13Ralpha1 in epidermal keratinocytes | MicroRNA-143 inhibits IL-13-induced dysregulation of the epidermal barrier-related proteins in skin keratinocytes via targeting to IL-13Rα1.
Zeng YP, Nguyen GH, Jin HZ. | 02/18/2017 |
| IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. | A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.
Karo-Atar D, Bordowitz A, Wand O, Pasmanik-Chor M, Fernandez IE, Itan M, Frenkel R, Herbert DR, Finkelman FD, Eickelberg O, Munitz A., Free PMC Article | 10/1/2016 |
| required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4 | The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4.
Sheikh F, Dickensheets H, Pedras-Vasconcelos J, Ramalingam T, Helming L, Gordon S, Donnelly RP., Free PMC Article | 06/28/2016 |
| analysis of IL-4 and IL-13 receptors in cancer biology and discussion of pre-clinical and clinical studies pertaining to recombinant immunotoxins designed to target these receptors [review] | Targeting of IL-4 and IL-13 receptors for cancer therapy.
Suzuki A, Leland P, Joshi BH, Puri RK. | 06/11/2016 |
| review of IL-4 and IL-13 receptor structure, receptor regulation, signaling and experimental therapeutics [review] | Commentary: IL-4 and IL-13 receptors and signaling.
McCormick SM, Heller NM., Free PMC Article | 06/11/2016 |
| Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. | IL13 Receptor α2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis.
Bartolomé RA, García-Palmero I, Torres S, López-Lucendo M, Balyasnikova IV, Casal JI. | 09/26/2015 |
| Data show that high expression of interleukin-4 receptor IL-4Ralpha correlated with increased recurrence, while interleukin-13 receptor IL-13Ralpha1 had an inverse relationship to recurrence and survival in oral cavity squamous cell carcinoma patients. | Recurrence and cancer-specific survival according to the expression of IL-4Rα and IL-13Rα1 in patients with oral cavity cancer.
Kwon M, Kim JW, Roh JL, Park Y, Cho KJ, Choi SH, Nam SY, Kim SY, Lee BH. | 05/2/2015 |
| miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1. | miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13Rα1.
Teng Y, Zhang R, Liu C, Zhou L, Wang H, Zhuang W, Huang Y, Hong Z. | 04/18/2015 |
| MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1. | MicroRNA-143 downregulates interleukin-13 receptor alpha1 in human mast cells.
Yu S, Zhang R, Zhu C, Cheng J, Wang H, Wu J., Free PMC Article | 03/22/2014 |
| Expression of IL-4, IL-4R, and IL-13R are involved in the process of local metastases in colorectal cancer, while IL-13 expression has an impact on survival. | Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer.
Formentini A, Braun P, Fricke H, Link KH, Henne-Bruns D, Kornmann M. | 07/13/2013 |
| In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease. | Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide.
Morrison BE, Marcondes MC, Nomura DK, Sanchez-Alavez M, Sanchez-Gonzalez A, Saar I, Kim KS, Bartfai T, Maher P, Sugama S, Conti B., Free PMC Article | 02/23/2013 |
| In Korean asthmatic children, increased serum IgE level was a multi-locus interaction between IL-4Ralpha, IL-13, IL-13Ralpha1, CD14, and CTLA4 polymorphisms. The combination of CTLA4/IL-13 and IL-13/IL-13Ralpha1 polymorphisms showed strong synergistic effects. | Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.
Choi WA, Kang MJ, Kim YJ, Seo JH, Kim HY, Kwon JW, Yu J, Park SJ, Lee YC, Hong SJ. | 11/24/2012 |
| The data provide evidence for codiffusion of IL-4-A647 bound IL-4Ralpha and the type II subunit IL-13Ralpha1 fused to enhanced green fluorescent protein. | Single cell analysis of ligand binding and complex formation of interleukin-4 receptor subunits.
Weidemann T, Worch R, Kurgonaite K, Hintersteiner M, Bökel C, Schwille P., Free PMC Article | 03/24/2012 |
| the combination of rs3091307 GG/ rs2265753 GG (IL-13/IL-13Ralpha1) conveyed a significantly higher risk for developing atopic dermatitis | Association of polymorphisms in genes encoding IL-4, IL-13 and their receptors with atopic dermatitis in a Korean population.
Namkung JH, Lee JE, Kim E, Kim HJ, Seo EY, Jang HY, Shin ES, Cho EY, Yang JM. | 03/10/2012 |
| These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production | A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis.
Wallis SK, Cooney LA, Endres JL, Lee MJ, Ryu J, Somers EC, Fox DA., Free PMC Article | 02/11/2012 |
| The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility. | Interleukin-13 receptor A1 gene polymorphism and IL-13 serum level in atopic and non-atopic Egyptian children.
Hussein YM, El-Tarhouny SA, Shalaby SM, Mohamed RH, Hassan TH, El-Sherbeny HM, Mohamed NA. | 10/1/2011 |
| IL-13Ralpha1 is expressed on human CD4(+) T(H)17 cells | Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production.
Newcomb DC, Boswell MG, Zhou W, Huckabee MM, Goleniewska K, Sevin CM, Hershey GK, Kolls JK, Peebles RS Jr., Free PMC Article | 06/4/2011 |
| The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1). | The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1).
Martinez-Nunez RT, Louafi F, Sanchez-Elsner T., Free PMC Article | 02/26/2011 |