| Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis. | Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis.
Ahmed AU, Almasabi S, Firestein R, Williams BRG., Free PMC Article | 12/20/2023 |
| Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis. | Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis.
Huang Q, Sun Y, Peng L, Sun J, Sha Z, Lin H, Li Y, Li C, Li H, Shang H, Chen Y, Dou X, Hu Z, Ye Z, Peng H., Free PMC Article | 06/29/2023 |
| Substrate Stiffness Regulates the Proliferation and Apoptosis of Periodontal Ligament Cells through Integrin-Linked Kinase ILK. | Substrate Stiffness Regulates the Proliferation and Apoptosis of Periodontal Ligament Cells through Integrin-Linked Kinase ILK.
Wang Y, Zhang H, Wu S, Wan W, Kang X, Gao B, Shi H, Zhao S, Niu L, Zou R. | 02/23/2023 |
| The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation. | The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation.
Petrou IG, Nikou S, Madduri S, Nifora M, Bravou V, Kalbermatten DF., Free PMC Article | 11/26/2022 |
| Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer. | Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer.
Kang N, Xie X, Zhou X, Wang Y, Chen S, Qi R, Liu T, Jiang H., Free PMC Article | 05/7/2022 |
| Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation. | Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation.
Campillo S, Bohorquez L, Gutiérrez-Calabrés E, García-Ayuso D, Miguel V, Griera M, Calle Y, de Frutos S, Rodríguez-Puyol M, Rodríguez-Puyol D, Calleros L., Free PMC Article | 04/16/2022 |
| Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors. | Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors.
Beetham H, Griffith BGC, Murina O, Loftus AEP, Parry DA, Temps C, Culley J, Muir M, Unciti-Broceta A, Sims AH, Byron A, Brunton VG., Free PMC Article | 03/12/2022 |
| Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis. | Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis.
Li CL, Li J, Gong SY, Huang M, Li R, Xiong GX, Wang F, Zou QM, Qi Q, Yin XX., Free PMC Article | 02/19/2022 |
| Integrin-linked kinase (ILK): the known vs. the unknown and perspectives. | Integrin-linked kinase (ILK): the known vs. the unknown and perspectives.
Górska A, Mazur AJ., Free PMC Article | 02/12/2022 |
| Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. | Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
Yang H, Lin L, Sun K, Zhang T, Chen W, Li L, Xie Y, Wu C, Wei Z, Yu C., Free PMC Article | 02/5/2022 |
| Role of integrinlinked kinase in static compressive stressinduced autophagy via phosphatidylinositol 3 kinase in human periodontal ligament cells. | Role of integrin‑linked kinase in static compressive stress‑induced autophagy via phosphatidylinositol 3 kinase in human periodontal ligament cells.
Zou R, Wu S, Wang Y, Kang X, Zhao S, Shi H, Zheng D, Gao B, Ma S, Niu L, Gao Y., Free PMC Article | 12/25/2021 |
| Integrin-Linked-Kinase Overexpression Is Implicated in Mechanisms of Genomic Instability in Human Colorectal Cancer. | Integrin-Linked-Kinase Overexpression Is Implicated in Mechanisms of Genomic Instability in Human Colorectal Cancer.
Chadla P, Arbi M, Nikou S, Kalliakoudas T, Papadaki H, Taraviras S, Lygerou Z, Bravou V. | 09/4/2021 |
| Integrin linked kinase regulates endosomal recycling of N-cadherin in melanoma cells. | Integrin linked kinase regulates endosomal recycling of N-cadherin in melanoma cells.
Gil D, Zarzycka M, Ciołczyk-Wierzbicka D, Laidler P. | 08/7/2021 |
| Rare genetic variants suggest dysregulation of signaling pathways in low- and high-risk patients developing severe ovarian hyperstimulation syndrome. | Rare genetic variants suggest dysregulation of signaling pathways in low- and high-risk patients developing severe ovarian hyperstimulation syndrome.
Borgwardt L, Olsen KW, Rossing M, Helweg-Larsen RB, Toftager M, Pinborg A, Bogstad J, Løssl K, Zedeler A, Grøndahl ML., Free PMC Article | 06/5/2021 |
| Integrin-Linked Kinase Links Integrin Activation to Invadopodia Function and Invasion via the p(T567)-Ezrin/NHERF1/NHE1 Pathway. | Integrin-Linked Kinase Links Integrin Activation to Invadopodia Function and Invasion via the p(T567)-Ezrin/NHERF1/NHE1 Pathway.
Greco MR, Moro L, Forciniti S, Alfarouk K, Cannone S, Cardone RA, Reshkin SJ., Free PMC Article | 05/29/2021 |
| Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival. | Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
Nikou S, Arbi M, Dimitrakopoulos FD, Sirinian C, Chadla P, Pappa I, Ntaliarda G, Stathopoulos GT, Papadaki H, Zolota V, Lygerou Z, Kalofonos HP, Bravou V. | 05/22/2021 |
| Soft Microenvironments Induce Chemoresistance by Increasing Autophagy Downstream of Integrin-Linked Kinase. | Soft Microenvironments Induce Chemoresistance by Increasing Autophagy Downstream of Integrin-Linked Kinase.
Anlaş AA, Nelson CM., Free PMC Article | 02/13/2021 |
| ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1. | ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1.
Louca M, Zaravinos A, Stylianopoulos T, Gkretsi V. | 02/6/2021 |
| Bioinformatics analysis suggested that ILK expression was elevated in ESCC tissues. Further validation indicated that expression of ILK was positively correlated with poor prognosis. Inhibition of ILK kinase activity by specific inhibitor termed Compound 22 (cpd22) blocked ESCC cells proliferation, invasion and migration and attenuated AKT phosphorylation. | Integrin-Linked Kinase Is Involved In the Proliferation and Invasion of Esophageal Squamous Cell Carcinoma.
Ning Z, Zhu X, Jiang Y, Gao A, Zou S, Gu C, He C, Chen Y, Ding WQ, Zhou J., Free PMC Article | 10/6/2020 |
| Drug resistance is closely associated with the inactivation of the hippo pathway protein Merlin/MST/LATS and the activation of YAP. | Matrix stiffness modulates ILK-mediated YAP activation to control the drug resistance of breast cancer cells.
Qin X, Lv X, Li P, Yang R, Xia Q, Chen Y, Peng Y, Li L, Li S, Li T, Jiang Y, Yang H, Wu C, Zheng C, Zhu J, You F, Wang H, Chen J, Liu Y. | 08/12/2020 |
| knockdown of ILK in periodontal ligament fibroblasts treated with mechanical stretching altered the composition of small-molecule metabolites | Effect of ILK on small-molecule metabolism of human periodontal ligament fibroblasts with mechanical stretching.
Wan W, He C, Du C, Wang Y, Wu S, Wang T, Zou R. | 07/18/2020 |
| Three loss-of-function mutations in human ILK were identified in genomic DNA samples from exudative retinopathy patients. | Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy.
Park H, Yamamoto H, Mohn L, Ambühl L, Kanai K, Schmidt I, Kim KP, Fraccaroli A, Feil S, Junge HJ, Montanez E, Berger W, Adams RH., Free PMC Article | 03/7/2020 |
| Data indicate that ILK facilitates mechanosensitive VEGFR3 signaling and physiologic lymph vessel expansion by controlling beta1 integrin-mediated VEGFR3 activation. | Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.
Urner S, Planas-Paz L, Hilger LS, Henning C, Branopolski A, Kelly-Goss M, Stanczuk L, Pitter B, Montanez E, Peirce SM, Mäkinen T, Lammert E., Free PMC Article | 12/28/2019 |
| The expression of ILK was significantly correlated with differentiation and metastasis of the laryngeal carcinomas. The inhibition of the ILK gene could downregulate the proliferation, migration and invasion of Hep-2 human laryngeal squamous cell carcinoma cells. Data suggested that ILK acts as an oncogene in laryngeal squamous cell carcinoma. | Integrin-linked kinase is overexpressed in laryngeal squamous cell carcinoma and correlates with tumor proliferation, migration and invasion.
Wu PA, Xie LL, Zhao DY, Li SS, Tang QL, Wang SH, Yang XM. | 12/14/2019 |
| findings provide genetic and functional evidence that ILK is a cardiomyopathy disease gene and highlight its relevance for diagnosis and genetic counseling of inherited cardiomyopathies | Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy.
Brodehl A, Rezazadeh S, Williams T, Munsie NM, Liedtke D, Oh T, Ferrier R, Shen Y, Jones SJM, Stiegler AL, Boggon TJ, Duff HJ, Friedman JM, Gibson WT, FORGE Canada Consortium, Childs SJ, Gerull B., Free PMC Article | 08/17/2019 |