| Actin-binding protein, IQGAP1, regulates LPS-induced RPMVECs hyperpermeability and ICAM-1 upregulation via Rap1/Src signalling pathway. | Actin-binding protein, IQGAP1, regulates LPS-induced RPMVECs hyperpermeability and ICAM-1 upregulation via Rap1/Src signalling pathway.
Zhang N, Wang G, Sun G. | 07/16/2022 |
| IQGAP1 not only exerts a crucial role in microvascular endothelium barrier but also plays an important role in inflammation | Transcriptomic Analysis of Pulmonary Microvascular Endothelial Cells with IQGAP1 Knockdown.
Su S, Xu A, Chen Y, Li W, Zha X, Wang Y, Sun G. | 07/25/2020 |
| In cultured rat aortic SMCs, PDGF stimulation rapidly promoted ATP7A association with IQGAP1 and Rac1 and their translocation to the lipid rafts and leading edge. Cotransfection assay revealed that ATP7A directly bound to NH2-terminal domain of IQGAP1 | Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffolding protein: role in PDGF-induced VSMC migration and vascular remodeling.
Ashino T, Kohno T, Sudhahar V, Ash D, Ushio-Fukai M, Fukai T., Free PMC Article | 07/13/2019 |
| These data are consistent with a model in which IQGAP1 cleavage is regulated by acetylation of the cleavage sites. Activation of ERK1/2 by ceramide, known to increase lysine acetylation, appears to be mediated by acetylation-dependent stabilization of IQGAP1. | A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1.
Vetterkind S, Lin QQ, Morgan KG., Free PMC Article | 04/20/2019 |
| IQGAP1 contributes to AngII-induced apoptosis of podocytes by interacting with the ERK1/2 signaling protein | IQGAP1 mediates angiotensin II-induced apoptosis of podocytes via the ERK1/2 MAPK signaling pathway.
Liu Y, Liang W, Yang Q, Ren Z, Chen X, Zha D, Singhal PC, Ding G. | 07/26/2014 |
| Caveolin-1 and IQGAP1 are required for phosphorylation of the actin associated pool of extracellular signal regulated kinase 1 and 2 (ERK1/2) in response to protein kinase C activation. | Hierarchical scaffolding of an ERK1/2 activation pathway.
Vetterkind S, Poythress RH, Lin QQ, Morgan KG., Free PMC Article | 02/22/2014 |
| IQGAP1 protein domains actively participate in spine morphogenesis and differentially affect spine number and shape. | Regulation of spine density and morphology by IQGAP1 protein domains.
Jausoro I, Mestres I, Quassollo G, Masseroni L, Heredia F, Caceres A., Free PMC Article | 08/31/2013 |
| These results suggest that Chlamydophila pneumoniae infection may promote the adhesion and migration of vascular smooth muscle cells possibly by upregulating the IQGAP1 expression. | Chlamydophila (Chlamydia) pneumoniae infection promotes vascular smooth muscle cell adhesion and migration through IQ domain GTPase-activating protein 1.
Zhang L, Li X, Zhang L, Wang B, Zhang T, Ye J. | 03/9/2013 |
| We postulate that mTOR controls dendritic arbor morphology by enhancing cross talk between dynamic microtubules and actin through CLIP-170 and IQGAP1 | CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology.
Swiech L, Blazejczyk M, Urbanska M, Pietruszka P, Dortland BR, Malik AR, Wulf PS, Hoogenraad CC, Jaworski J., Free PMC Article | 05/28/2011 |
| IQGAP1 mRNA and protein expression levels increased significantly throughout hepatotumorigenesis. IQGAP1 is an important node in underlying gene regulatory networks. | IQGAP1 and vimentin are key regulator genes in naturally occurring hepatotumorigenesis induced by oxidative stress.
Tsubota A, Matsumoto K, Mogushi K, Nariai K, Namiki Y, Hoshina S, Hano H, Tanaka H, Saito H, Tada N. | 04/19/2010 |
| IQGAP1 is a potential target protein of S100B during processes of dynamic rearrangement of cell membrane morphology [IQGAP1] | The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes.
Mbele GO, Deloulme JC, Gentil BJ, Delphin C, Ferro M, Garin J, Takahashi M, Baudier J. | 01/21/2010 |
| IQGAP1 functions as a VEGFR2-associated scaffold protein to organize ROS-dependent VEGF signaling, thereby promoting EC migration and proliferation, which may contribute to repair and maintenance of the functional integrity of established blood vessels. | IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.
Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L, Dikalov SI, Chen YE, Tojo T, Fukai T, Fujimoto M, Patrushev NA, Wang N, Kontos CD, Bloom GS, Alexander RW. | 01/21/2010 |
| Data suggest that cyclic AMP/protein kinase A may be coupled with calcium/calmodulin and guanosine triphosphatases through an IQGAP1/AKAP79 complex. | Identification of an IQGAP1/AKAP79 complex in beta-cells.
Nauert JB, Rigas JD, Lester LB. | 01/21/2010 |
| Our results suggest a model in which calmodulin is targeted to and sequestered at the actin cytoskeleton by IQGAP1 | Targeting of calcium:calmodulin signals to the cytoskeleton by IQGAP1.
Psatha MI, Razi M, Koffer A, Moss SE, Sacks DB, Bolsover SR. | 01/21/2010 |
| role of the Rac/Cdc42-IQGAP1 system in the dynamic organization and maintenance of the E-cadherin-based adherens junctions | Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments.
Izumi G, Sakisaka T, Baba T, Tanaka S, Morimoto K, Takai Y., Free PMC Article | 01/21/2010 |
| Interactions among IQGAP1, Cdc42, and beta-catenin are crucial to the regulation of Sertoli-germ cell, but not Sertoli-Sertoli cell, adherens junction dynamics in the seminiferous epithelium. | Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis.
Lui WY, Mruk DD, Cheng CY. | 01/21/2010 |