| The Role and Mechanism of STIM1/Orai1-Regulated Ca[2+] Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus. | The Role and Mechanism of STIM1/Orai1-Regulated Ca(2+) Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus.
Zhang S, Zang W. | 03/28/2024 |
| Genotypes of Stim1 and the proximal region on chromosome 1 exert opposite effects on stroke susceptibility in stroke-prone spontaneously hypertensive rat. | Genotypes of Stim1 and the proximal region on chromosome 1 exert opposite effects on stroke susceptibility in stroke-prone spontaneously hypertensive rat.
Ohara H, Takeuchi F, Kato N, Nabika T. | 12/5/2023 |
| Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons. | Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons.
Tedeschi V, Sisalli MJ, Pannaccione A, Piccialli I, Molinaro P, Annunziato L, Secondo A. | 02/5/2022 |
| STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats. | STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats.
Iranipour N, Babaei-Balderlou F, Maleki A, Moslemi M, Khodagholi F. | 02/5/2022 |
| Mapping the Proximity Interaction Network of STIM1 Reveals New Mechanisms of Cytoskeletal Regulation. | Mapping the Proximity Interaction Network of STIM1 Reveals New Mechanisms of Cytoskeletal Regulation.
Gammons J, Halpage J, Mancarella S., Free PMC Article | 12/4/2021 |
| Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension. | Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension.
Xu F, Zhu J, Chen Y, He K, Guo J, Bai S, Zhao R, Du J, Shen B. | 07/24/2021 |
| Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning. | Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning.
Tedeschi V, Sisalli MJ, Petrozziello T, Canzoniero LMT, Secondo A. | 06/26/2021 |
| Natural genetic variation in Stim1 creates stroke in the spontaneously hypertensive rat. | Natural genetic variation in Stim1 creates stroke in the spontaneously hypertensive rat.
Dhande IS, Kneedler SC, Zhu Y, Joshi AS, Hicks MJ, Wenderfer SE, Braun MC, Doris PA., Free PMC Article | 06/5/2021 |
| Pathophysiological significance of Stim1 mutation in sympathetic response to stress and cardiovascular phenotypes in SHRSP/Izm: In vivo evaluation by creation of a novel gene knock-in rat using CRISPR/Cas9. | Pathophysiological significance of Stim1 mutation in sympathetic response to stress and cardiovascular phenotypes in SHRSP/Izm: In vivo evaluation by creation of a novel gene knock-in rat using CRISPR/Cas9.
Odongoo B, Ohara H, Ngarashi D, Kaneko T, Kunihiro Y, Mashimo T, Nabika T. | 05/8/2021 |
| STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons. | STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
Gruszczynska-Biegala J, Strucinska K, Maciag F, Majewski L, Sladowska M, Kuznicki J., Free PMC Article | 01/16/2021 |
| This study demonstrated two obligatory roles of STIM1 for muscarinic activation of TRPC1-TRPC4 channels in PC12 cells. One is to facilitate heteromeric channel formation of TRPC1 with TRPC4. The second is to facilitate the insertion of TRPC1-TRPC4 channels into the cell membrane in response to muscarinic receptor stimulation. | STIM1-dependent membrane insertion of heteromeric TRPC1-TRPC4 channels in response to muscarinic receptor stimulation.
Harada K, Matsuoka H, Inoue M. | 07/4/2020 |
| We demonstrate a novel role for stromal interacting molecule 1 (STIM1) in regulating microtubule and subsequent ER remodeling in navigating growth cones. We show that STIM1, an activator of store-operated calcium entry, regulates the dynamics of microtubule-binding proteins EB1/EB3, coupling ER to microtubules, within filopodia, thereby steering growth cones | STIM1 Is Required for Remodeling of the Endoplasmic Reticulum and Microtubule Cytoskeleton in Steering Growth Cones.
Pavez M, Thompson AC, Arnott HJ, Mitchell CB, D'Atri I, Don EK, Chilton JK, Scott EK, Lin JY, Young KM, Gasperini RJ, Foa L., Free PMC Article | 06/20/2020 |
| STIM1 and ORAI1 expression decreased in the temporoparietal cortex following transient middle cerebral artery occlusion. | ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection Induced by Ischemic Preconditioning Through Store-Operated Calcium Entry.
Secondo A, Petrozziello T, Tedeschi V, Boscia F, Vinciguerra A, Ciccone R, Pannaccione A, Molinaro P, Pignataro G, Annunziato L. | 01/11/2020 |
| STIM1L/Orai1/TRPC1/C4-dependent Ca(2+) current participates in Ca(2+) remodeling in right ventricular hypertrophy secondary to pulmonary hypertension. | Ca(2+) handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.
Sabourin J, Boet A, Rucker-Martin C, Lambert M, Gomez AM, Benitah JP, Perros F, Humbert M, Antigny F. | 06/29/2019 |
| In the rough endoplasmic reticulum, STIM1 interacts with and is located with Prx-4 in liver microsomes. | Evidence for the interaction of peroxiredoxin-4 with the store-operated calcium channel activator STIM1 in liver cells.
Tam KC, Ali E, Hua J, Chataway T, Barritt GJ. | 05/11/2019 |
| When exposed to high tidal volume or large-magnitude CS, Stim1 and Orai1 expression are upregulated, which further activates calcium-sensitive PKCalpha and results in calcium overload, endothelial hyperpermeability, and, finally, lung injury. | Stromal-Interacting Molecule 1 (Stim1)/Orai1 Modulates Endothelial Permeability in Ventilator-Induced Lung Injury.
Song X, Liu Y, Dong L, Wang Y., Free PMC Article | 03/9/2019 |
| Store operated calcium channels are associated with diabetic cystopathy in streptozotocininduced diabetic rats. | Store operated calcium channels are associated with diabetic cystopathy in streptozotocin‑induced diabetic rats.
Yang S, Wang D, Cao X, Zhang X, Yuan X, Yang T, Mi Y., Free PMC Article | 09/15/2018 |
| Suppression of STIM1 reduced intracellular calcium level and attenuated hypoxia/reoxygenation induced apoptosis in H9C2 cardiomyocytes. | Suppression of Stim1 reduced intracellular calcium concentration and attenuated hypoxia/reoxygenation induced apoptosis in H9C2 cells.
He F, Wu Q, Xu B, Wang X, Wu J, Huang L, Cheng J., Free PMC Article | 08/4/2018 |
| downregulation of miR-223 by phenylephrine contributed to the increase of STIM1, which in turn induced cardiac hypertrophy. | SOX2-mediated inhibition of miR-223 contributes to STIM1 activation in phenylephrine-induced hypertrophic cardiomyocytes.
Zhao ZH, Luo J, Li HX, Wang SH, Li XM. | 07/14/2018 |
| STIM1 may play an important role in the pathogenesis of alcoholic liver disease. | RNA interference against stromal interacting molecule-1 (STIM1) ameliorates ethanol-induced hepatotoxicity.
Cui R, Li R, Guo X, Jia X, Yan M. | 06/9/2018 |
| Hypertrophic aortic remodeling and abnormal contraction triggered mainly by Ca2+ overload via STIM-1/Orai-1-mediated SOCE through SOCCs are involved hypertension developed by EtOH consumption. | Functional Upregulation of STIM-1/Orai-1-Mediated Store-Operated Ca2+ Contributing to the Hypertension Development Elicited by Chronic EtOH Consumption.
Souza Bomfim GH, Mendez-Lopez I, Arranz-Tagarro JA, Ferraz Carbonel AA, Roman-Campos D, Padín JF, Garcia AG, Jurkiewicz A, Jurkiewicz NH. | 12/16/2017 |
| Cultured hippocampal neurons expressing mutant PS1 had attenuated CCE that was associated with destabilized dendritic spines, which were rescued by either gamma-secretase inhibition or overexpression of STIM1. | Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.
Tong BC, Lee CS, Cheng WH, Lai KO, Foskett JK, Cheung KH., Free PMC Article | 11/26/2017 |
| Ang-II-induced Egr-1 expression is mediated by STIM-1/Orai-1/Ca(2+) -dependent signaling pathways in vascular smooth muscle cells. | STIM-1 and ORAI-1 channel mediate angiotensin-II-induced expression of Egr-1 in vascular smooth muscle cells.
Simo-Cheyou ER, Tan JJ, Grygorczyk R, Srivastava AK. | 10/7/2017 |
| Neuronal aging is associated to increased ER-mitochondrial cross talking and loss of store-operated calcium entry via Stim1/Orai1. | In vitro aging promotes endoplasmic reticulum (ER)-mitochondria Ca(2+) cross talk and loss of store-operated Ca(2+) entry (SOCE) in rat hippocampal neurons.
Calvo-Rodríguez M, García-Durillo M, Villalobos C, Núñez L. | 07/1/2017 |
| The function of STIM1 in the regulation of the store-operated Ca(2+)-entry in astrocytes | A nonsense mutation of Stim1 identified in stroke-prone spontaneously hypertensive rats decreased the store-operated calcium entry in astrocytes.
Ohara H, Nabika T. | 05/27/2017 |