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    INHA inhibin subunit alpha [ Homo sapiens (human) ]

    Gene ID: 3623, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Altered Endometrial Expression of alpha-Inhibin Subunit and Its Co-Receptor Betaglycan in Infertile Women with Endometriosis.

    Altered Endometrial Expression of α-Inhibin Subunit and Its Co-Receptor Betaglycan in Infertile Women with Endometriosis.
    Dela Cruz C, Vilamil QT, Casalechi M, Rezende CP, Assis WA, Del Puerto HL, Abrão MS, Reis FM.

    10/15/2022
    Testicular Sertoli Cell Hormones in Differences in Sex Development.

    Testicular Sertoli Cell Hormones in Differences in Sex Development.
    Lucas-Herald AK, Mitchell RT., Free PMC Article

    08/6/2022
    Homozygosity for a novel INHA mutation in two male siblings with hypospadias, primary hypogonadism, and high-normal testicular volume.

    Homozygosity for a novel INHA mutation in two male siblings with hypospadias, primary hypogonadism, and high-normal testicular volume.
    Arslan Ates E, Eltan M, Sahin B, Gurpinar Tosun B, Seven Menevse T, Geckinli BB, Greenfield A, Turan S, Bereket A, Guran T., Free PMC Article

    04/2/2022
    An exome-wide exploration of cases of primary ovarian insufficiency uncovers novel sequence variants and candidate genes.

    An exome-wide exploration of cases of primary ovarian insufficiency uncovers novel sequence variants and candidate genes.
    Alvarez-Mora MI, Todeschini AL, Caburet S, Perets LP, Mila M, Younis JS, Shalev S, Veitia RA.

    07/17/2021
    Variations in the inhibin gene in Kashmiri women with primary ovarian insufficiency.

    Variations in the inhibin gene in Kashmiri women with primary ovarian insufficiency.
    Zargar MH, Shafia S, Masoodi SR, Mahajan Q, Khan N, Ahmad R.

    05/8/2021
    PAPP-A2 and Inhibin A as Novel Predictors for Pregnancy Complications in Women With Suspected or Confirmed Preeclampsia.

    PAPP-A2 and Inhibin A as Novel Predictors for Pregnancy Complications in Women With Suspected or Confirmed Preeclampsia.
    Neuman RI, Alblas van der Meer MM, Nieboer D, Saleh L, Verdonk K, Kalra B, Kumar A, Alpadi K, van den Meiracker AH, Visser W, Danser AHJ., Free PMC Article

    03/20/2021
    ALK4-SMAD3/4 mediates the effects of activin A on the upregulation of PAI-1 in human granulosa lutein cells.

    ALK4-SMAD3/4 mediates the effects of activin A on the upregulation of PAI-1 in human granulosa lutein cells.
    Chen B, Chang HM, Zhang Z, Cao Y, Leung PCK.

    02/6/2021
    Association of polymorphism c.-124G>A and c.-16 C>T in the promoter region of human INHA gene with altered sperm parameters; A pilot study.

    Association of polymorphism c.-124G>A and c.-16 C>T in the promoter region of human INHA gene with altered sperm parameters; A pilot study.
    Rafaqat W, Kayani MR, Fatima T, Shaharyar S, Khan S, Ashraf M, Afzal U, Rehman R.

    02/2/2021
    Engineering the Ovarian Hormones Inhibin A and Inhibin B to Enhance Synthesis and Activity.

    Engineering the Ovarian Hormones Inhibin A and Inhibin B to Enhance Synthesis and Activity.
    Goney MP, Wilce MCJ, Wilce JA, Stocker WA, Goodchild GM, Chan KL, Harrison CA, Walton KL.

    01/9/2021
    Polymorphisms in inhibin alpha gene promoter associated with male infertility.

    Association of single nucleotide polymorphism in the promoter region of the Inhibin α gene with infertility in Pakistani males.
    Fatima T, Khan S, Rehman R.

    07/18/2020
    Investigated the association between polycystic ovary syndrome (PCOS) and obesity and insulin resistance (IR) with respect to anti-Mullerian hormone (AMH), inhibin A (INH-A), inhibin B (INH-B), and insulin-like peptide 3 (INSL3) plasma levels.

    Determination of insulin resistance and its relationship with hyperandrogenemia,anti-Müllerian hormone, inhibin A, inhibin B, and insulin-like peptide-3 levels in adolescent girls with polycystic ovary syndrome.
    Yetim Şahin A, Baş F, Yetim Ç, Uçar A, Poyrazoğlu Ş, Bundak R, Darendeliler F., Free PMC Article

    02/22/2020
    Activin A (follicle-stimulating hormone-releasing protein inhibin beta A subunit inhibin beta A) signaling is restrained in normal mammary epithelia by concomitant inhibin alpha-subunit expression, and relatively higher levels of follistatin (FST) expression, however, these expression patterns are reversed in breast cancer [Review].

    The Activin Social Network: Activin, Inhibin, and Follistatin in Breast Development and Cancer.
    Seachrist DD, Keri RA., Free PMC Article

    12/21/2019
    Data show that the inclusion of inhibin A in screening protocols reduces the number of positive results in high risk population screened without inhibin A.

    The Effect of Inhibin A on Prenatal Screening Results for Down Syndrome in the High Risk Czech Pregnant Women.
    Loucký J, Bělášková S, Průša R, Kotaška K.

    12/7/2019
    INHA inhibits BMP9-induced osteogenic differentiation through blocking BMP/Smad signal and activating NF-kappaB signal in mesenchymal stem cells.

    Inhibin α-subunit inhibits BMP9-induced osteogenic differentiation through blocking BMP/Smad signal and activating NF-κB signal in mesenchymal stem cells.
    Huang M, Cheng YL, Zeng JT, Su XY, Liu H.

    10/12/2019
    identify the BGZP-C-binding site on TGF-beta2 and shed light on the specificity of BG for select TGF-beta-type GFs and the mechanisms by which BG influences their signaling

    TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
    Henen MA, Mahlawat P, Zwieb C, Kodali RB, Hinck CS, Hanna RD, Krzysiak TC, Ilangovan U, Cano KE, Hinck G, Vonberg M, McCabe M, Hinck AP., Free PMC Article

    05/11/2019
    Genetic variation in growth factor pathway genes INHA and IGFBP1/3 may predict longitudinal mammographic density change after women quit estrogen and progestin combined therapy .

    Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study.
    Lee E, Luo J, Schumacher FR, Van Den Berg D, Wu AH, Stram DO, Bernstein L, Ursin G., Free PMC Article

    02/16/2019
    Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis.

    Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis.
    Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K., Free PMC Article

    10/9/2018
    HIF1A and EPAS1 potentiate hypoxia-induced upregulation of INHA expression in human term cytotrophoblasts in vitro.

    HIF1A and EPAS1 potentiate hypoxia-induced upregulation of inhibin alpha chain expression in human term cytotrophoblasts in vitro.
    Depoix CL, de Selliers I, Hubinont C, Debieve F.

    12/23/2017
    There is genetic heterogeneity regarding the INHA gene in different populations, and among the causes of premature ovarian insufficiency. The G769A variant was found in only one patient in the Premature Ovarian Insufficiency Group and in no control, and it appears to be rare in Brazilian patients with premature ovarian insufficiency.

    How polymorphic markers contribute to genetic diseases in different populations? The study of inhibin A for premature ovarian insufficiency.
    Christofolini DM, Cordts EB, Santos-Pinheiro F, Kayaki EA, Dornas MCF, Santos MC, Bianco B, Barbosa CP., Free PMC Article

    12/9/2017
    Inhibin-alpha gene is transcriptionally silenced in human leukemia cells. In addition, mutations in, and expression levels of, the inhibin-alpha gene differed between human lymphoid and myeloid leukemia cells.

    Inhibin-α gene mutations and mRNA levels in human lymphoid and myeloid leukemia cells.
    Kim YI, Park SW, Kwon HS, Yang HS, Cho SY, Kim YJ, Lee HJ.

    07/22/2017
    Results suggest that high expression levels of alpha-inhibin and beta-glycan transcripts in secretory phase endometrium are associated with a lower chance of achieving pregnancy with in vitro fertilization.

    Implantation Failure Is Associated With Increased α-Inhibin and β-Glycan Gene Expression in Secretory Phase Endometrium: Nested Case-Control Study of Infertile Women Undergoing IVF/Fresh Embryo Transfer.
    Silveira CO, Rezende CP, Ferreira MC, Del Puerto HL, Reis FM.

    05/7/2017
    Anti-Mullerian hormone (AMH) and inhibin-A (INH-A) levels were found to be significantly higher in the polycystic ovary syndrome (PCOS) group compared to the controls.

    Anti-Müllerian Hormone and Inhibin-A, but not Inhibin-B or Insulin-Like Peptide-3, may be Used as Surrogates in the Diagnosis of Polycystic Ovary Syndrome in Adolescents: Preliminary Results.
    Yetim A, Yetim Ç, Baş F, Erol OB, Çığ G, Uçar A, Darendeliler F., Free PMC Article

    04/22/2017
    Immunostaining allowed the identification of specific cell types with E-cadherin, p53, and inhibin-alpha expression in all cases.

    Immunohistochemical Analysis of E-Cadherin, p53 and Inhibin-α Expression in Hydatidiform Mole and Hydropic Abortion.
    Erol O, Süren D, Tutuş B, Toptaş T, Gökay AA, Derbent AU, Özel MK, Sezer C.

    03/18/2017
    Each follicular fluid (FF) was individually aspirated and FF/serum EG-VEGF, inhibin-a, and FF IGF-1 levels were evaluated. The pregnant group was characterized by increased numbers of WVFs (p = 0.044), a WVE (p = 0.022), and increased levels of FF IGF-1 (p = 0.001) and serum EG-VEGF (p = 0.03).

    Perifollicular blood flow and its relationship with endometrial vascularity, follicular fluid EG-VEGF, IGF-1, and inhibin-a levels and IVF outcomes.
    Vural F, Vural B, Doğer E, Çakıroğlu Y, Çekmen M., Free PMC Article

    03/18/2017
    The Sertoli cell hormones inhibin-B and anti Mullerian hormone have different patterns of secretion in prepubertal cryptorchid boys.

    The Sertoli cell hormones inhibin-B and anti Müllerian hormone have different patterns of secretion in prepubertal cryptorchid boys.
    Cortes D, Clasen-Linde E, Hutson JM, Li R, Thorup J.

    10/29/2016
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