| Blocking the Spinal Fbxo3/CARM1/K(+) Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief. | Blocking the Spinal Fbxo3/CARM1/K(+) Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief.
Hsieh MC, Ho YC, Lai CY, Wang HH, Yang PS, Cheng JK, Chen GD, Ng SC, Lee AS, Tseng KW, Lin TB, Peng HY., Free PMC Article | 02/5/2022 |
| Mechanistically, PRMT4 overexpression promoted hypoxia-induced cardiomyocytes apoptosis, while its inhibition abolished these effects. | PRMT4 overexpression aggravates cardiac remodeling following myocardial infarction by promoting cardiomyocyte apoptosis.
Wang Y, Ju C, Hu J, Huang K, Yang L. | 07/18/2020 |
| These results suggest that CARM1 is a post-synaptic protein that plays roles in dendritic maturation and synaptic formation and that spatiotemporal regulation of CARM1 activity modulates neuronal connectivity and improves synaptic dysfunction. | Inhibition of coactivator-associated arginine methyltransferase 1 modulates dendritic arborization and spine maturation of cultured hippocampal neurons.
Lim CS, Alkon DL., Free PMC Article | 04/29/2017 |
| The silencing of CARM1 using siRNA increased Notch1 expression, the transcriptional activity of Hes, and podocyte apoptosis. | Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy.
Kim D, Lim S, Park M, Choi J, Kim J, Han H, Yoon K, Kim K, Lim J, Park S. | 03/7/2015 |
| high-glucose-induced CARM1 expression increases RPE cell apoptosis via H3R17 asymmetric dimethylation | High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.
Kim DI, Park MJ, Lim SK, Choi JH, Kim JC, Han HJ, Kundu TK, Park JI, Yoon KC, Park SW, Park JS, Heo YR, Park SH. | 11/8/2014 |
| aberrantly expressed CARM1 in tumor marker-positive cells promotes tumorigenesis in the early stages of hepatocarcinogenesis. | Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
Osada S, Suzuki S, Yoshimi C, Matsumoto M, Shirai T, Takahashi S, Imagawa M. | 05/3/2014 |
| PKC may play an important role in neuronal differentiation and synaptogenesis via stimulating HuD-mediated mRNA stability and inhibiting CARM1 in hippocampal neurons | Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture.
Lim CS, Alkon DL. | 06/29/2013 |
| the N-terminal and the C-terminal end of CARM1 catalytic module contain molecular switches that may determine how CARM1 regulates its biological activities by protein-protein interactions | Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains.
Troffer-Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J., Free PMC Article | 01/21/2010 |
| biochemical analysis of CARM1 methyltransferase and the histone code | Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.
Yue WW, Hassler M, Roe SM, Thompson-Vale V, Pearl LH., Free PMC Article | 01/21/2010 |
| CARM1 has a role in signal-dependent control of gluconeogenic key enzyme genes | Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1.
Krones-Herzig A, Mesaros A, Metzger D, Ziegler A, Lemke U, Brüning JC, Herzig S. | 01/21/2010 |
| CARM1 methylated HuD maintains cells in the proliferative state, a novel mechanism of arginine methylation of HuD by coactivator-associated arginine methyltransferase 1 (CARM1) that affected mRNA turnover | CARM1 regulates proliferation of PC12 cells by methylating HuD.
Fujiwara T, Mori Y, Chu DL, Koyama Y, Miyata S, Tanaka H, Yachi K, Kubo T, Yoshikawa H, Tohyama M., Free PMC Article | 01/21/2010 |