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    INSR insulin receptor [ Homo sapiens (human) ]

    Gene ID: 3643, updated on 4-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility.

    Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility.
    Ciulei G, Orășan OH, Cozma A, Negrean V, Para I, Ciumărnean L, Leach N, Lucaciu RL, Hangan AC, Procopciuc LM., Free PMC Article

    10/9/2024
    The interaction between magnesium intake, the genetic variant INSR rs1799817 and colorectal cancer risk in a Korean population: a case-control study.

    The interaction between magnesium intake, the genetic variant INSR rs1799817 and colorectal cancer risk in a Korean population: a case-control study.
    Nguyen LTD, Gunathilake M, Lee J, Oh JH, Chang HJ, Sohn DK, Shin A, Kim J.

    09/11/2024
    Insulin receptor orchestrates kidney antibacterial defenses.

    Insulin receptor orchestrates kidney antibacterial defenses.
    Schwartz L, Simoni A, Yan P, Salamon K, Turkoglu A, Vasquez Martinez G, Zepeda-Orozco D, Eichler T, Wang X, Spencer JD.,

    08/2/2024
    The brain insulin receptor gene network and associations with frailty index.

    The brain insulin receptor gene network and associations with frailty index.
    Selenius JS, Silveira PP, Haapanen MJ, von Bonsdorff M, Lahti J, Eriksson JG, Wasenius NS., Free PMC Article

    07/16/2024
    Activation of the insulin receptor by insulin-like growth factor 2.

    Activation of the insulin receptor by insulin-like growth factor 2.
    An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E., Free PMC Article

    04/17/2024
    The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.

    The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.
    Clark NK, Harris MT, Dahl WB, Knotts Z, Marr MT 2nd., Free PMC Article

    02/15/2024
    Insulin Signaling Through the Insulin Receptor Increases Linear Growth Through Effects on Bone and the GH-IGF-1 Axis.

    Insulin Signaling Through the Insulin Receptor Increases Linear Growth Through Effects on Bone and the GH-IGF-1 Axis.
    Okawa MC, Tuska RM, Lightbourne M, Abel BS, Walter M, Dai Y, Cochran E, Brown RJ., Free PMC Article

    01/11/2024
    Association between diabetes and stress-induced hyperglycemia with skeletal muscle gene expression of INSR in critically ill patients: A prospective cohort study.

    Association between diabetes and stress-induced hyperglycemia with skeletal muscle gene expression of INSR in critically ill patients: A prospective cohort study.
    Bellaver P, Schaeffer AF, Dullius DP, Crispim D, Leitão CB, Rech TH.

    11/30/2023
    Can obesity exacerbate hyperinsulinaemia in the presence of the mutation of an insulin receptor gene?

    Can obesity exacerbate hyperinsulinaemia in the presence of the mutation of an insulin receptor gene?
    Calcaterra V, Zuccotti G, Mari A, Iafusco F, Maione G, Iafusco D, Tinto N.

    11/18/2023
    Insulin receptor-inspired soluble insulin binder.

    Insulin receptor-inspired soluble insulin binder.
    Mendoza C, Hanegan C, Sperry A, Vargas L, Case T, Bikman B, Mizrachi D.

    10/28/2023
    Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study.

    Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study.
    Qin C, Diaz-Gallo LM, Tang B, Wang Y, Nguyen TD, Harder A, Lu Y, Padyukov L, Askling J, Hägg S., Free PMC Article

    08/1/2023
    The Activation Mechanism of the Insulin Receptor: A Structural Perspective.

    The Activation Mechanism of the Insulin Receptor: A Structural Perspective.
    Choi E, Bai XC., Free PMC Article

    06/23/2023
    Associations between heredity, height, BMI, diabetes mellitus type 1 or 2 and gene variants in the insulin receptor (INSR) gene in patients with schizophrenia.

    Associations between heredity, height, BMI, diabetes mellitus type 1 or 2 and gene variants in the insulin receptor (INSR) gene in patients with schizophrenia.
    Melkersson K, Persson B.

    05/30/2023
    Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes.

    Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes.
    Aji G, Jiang S, Obulkasim H, Lu Z, Wang W, Xia P., Free PMC Article

    03/6/2023
    Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.

    Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.
    Nagao H, Cai W, Brandão BB, Wewer Albrechtsen NJ, Steger M, Gattu AK, Pan H, Dreyfuss JM, Wunderlich FT, Mann M, Kahn CR., Free PMC Article

    03/6/2023
    Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis.

    Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis.
    Nagao H, Jayavelu AK, Cai W, Pan H, Dreyfuss JM, Batista TM, Brandão BB, Mann M, Kahn CR., Free PMC Article

    01/28/2023
    The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.

    The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.
    Dall'Agnese A, Platt JM, Zheng MM, Friesen M, Dall'Agnese G, Blaise AM, Spinelli JB, Henninger JE, Tevonian EN, Hannett NM, Lazaris C, Drescher HK, Bartsch LM, Kilgore HR, Jaenisch R, Griffith LG, Cisse II, Jeppesen JF, Lee TI, Young RA., Free PMC Article

    12/17/2022
    Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology.

    Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology.
    Shen WB, Elahi M, Wang B, Zhan M, Yang P, Yang P.

    11/26/2022
    Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.

    Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.
    Abdellatif M, Madeo F, Kroemer G, Sedej S., Free PMC Article

    10/8/2022
    Excess 11-Oxygenated Androgens in Women With Severe Insulin Resistance Are Mediated by Adrenal Insulin Receptor Signaling.

    Excess 11-Oxygenated Androgens in Women With Severe Insulin Resistance Are Mediated by Adrenal Insulin Receptor Signaling.
    Walzer D, Turcu AF, Jha S, Abel BS, Auchus RJ, Merke DP, Brown RJ., Free PMC Article

    08/27/2022
    Case Report: A Chinese Family of Type A Insulin Resistance Syndrome With Diabetes Mellitus, With a Novel Heterozygous Missense Mutation of the Insulin Receptor Gene.

    Case Report: A Chinese Family of Type A Insulin Resistance Syndrome With Diabetes Mellitus, With a Novel Heterozygous Missense Mutation of the Insulin Receptor Gene.
    You W, Yang J, Wang L, Liu Y, Wang W, Zhu L, Wang W, Yang J, Chen F., Free PMC Article

    08/27/2022
    Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood-Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells.

    Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood-Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells.
    Nagano H, Ito S, Masuda T, Ohtsuki S.

    07/9/2022
    Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.

    Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
    Nielsen J, Brandt J, Boesen T, Hummelshøj T, Slaaby R, Schluckebier G, Nissen P.

    05/21/2022
    Biological functions of nuclear-localized insulin receptor (IR) on A549 lung cancer cells.

    Biological functions of nuclear-localized insulin receptor (IR) on A549 lung cancer cells.
    Qiu R, Miao T, Lin L, Wei Z.

    04/16/2022
    Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease.

    Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease.
    Luo F, Xing C, Asrani SK, Li S, Liang G, Hobbs HH, Cohen JC., Free PMC Article

    03/26/2022
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