Activation of the cGAS-STING-IRF3 Axis by Type I and II Interferons Contributes to Host Defense.
Tong Z, Zou JP, Wang SY, Luo WW, Wang YY., Free PMC Article

Expression of human Interferon Regulatory Factor 3 (IRF-3) in alveolar macrophages relates to clinical and functional traits in COPD.
Baraldo S, Bonato M, Cassia S, Casolari P, De Ferrari L, Tiné M, Baraldi F, Bigoni T, Riccio AM, Braido F, Saetta M, Papi A, Contoli M., Free PMC Article

Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Wu B, Li D, Bai H, Mo R, Li H, Xie J, Zhang X, Yang Y, Li H, Idris A, Li X, Feng R.

Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.
Zhou Y, Li H, Zhang Y, Zhao E, Huang C, Pan X, Shu F, Liu Z, Tang N, Li F, Liao W.

IRF3 function and immunological gaps in sepsis.
Basak B, Akashi-Takamura S., Free PMC Article

Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1.
Zhuang Y, Ortega-Ribera M, Thevkar Nagesh P, Joshi R, Huang H, Wang Y, Zivny A, Mehta J, Parikh SM, Szabo G.,

The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3.
Dodantenna N, Cha JW, Chathuranga K, Chathuranga WAG, Weerawardhana A, Ranathunga L, Kim Y, Jheong W, Lee JS., Free PMC Article

Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer.
Alaimo A, Genovesi S, Annesi N, De Felice D, Subedi S, Macchia A, La Manna F, Ciani Y, Vannuccini F, Mugoni V, Notarangelo M, Libergoli M, Broso F, Taulli R, Ala U, Savino A, Cortese M, Mirzaaghaei S, Poli V, Bonapace IM, Papotti MG, Molinaro L, Doglioni C, Caffo O, Anesi A, Nagler M, Bertalot G, Carbone FG, Barbareschi M, Basso U, Dassi E, Pizzato M, Romanel A, Demichelis F, Kruithof-de Julio M, Lunardi A., Free PMC Article

Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation.
Yu JH, Choi MG, Lee NY, Kwon A, Lee E, Koo JH., Free PMC Article

FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
Xu Z, Tian M, Tan Q, Hao P, Gao Z, Li C, Jin N., Free PMC Article

Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3.
Wang J, Zheng H, Dong C, Xiong S., Free PMC Article

Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response.
Li WW, Fan XX, Zhu ZX, Cao XJ, Zhu ZY, Pei DS, Wang YZ, Zhang JY, Wang YY, Zheng HX., Free PMC Article

Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma.
Lv Z, Gao W, Du Z, Zheng Y, Liu T, Hao C, Xue D., Free PMC Article

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913.
Kazmierski J, Elsner C, Döhner K, Xu S, Ducroux A, Pott F, Jansen J, Thorball CW, Zeymer O, Zhou X, Fedorov R, Fellay J, Löffler MW, Weber ANR, Sodeik B, Goffinet C.

Human cytomegalovirus UL36 inhibits IRF3-dependent immune signaling to counterbalance its immunoenhancement as apoptotic inhibitor.
Ren Y, Wang A, Zhang B, Ji W, Zhu XX, Lou J, Huang M, Qiu Y, Zhou X., Free PMC Article

Multi-functional regulation of cGAS by the nuclear localization signal2 (NLS2) motif: Nuclear localization, enzyme activity and protein degradation.
Kim EY, Basit A, Kim WJ, Ko EB, Lee JH.

Serine-arginine splicing factor 2 promotes oesophageal cancer progression by regulating alternative splicing of interferon regulatory factor 3.
Wei Z, Wang Y, Ma W, Xing W, Lu P, Shang Z, Li F, Li H, Wang Y., Free PMC Article

SARS-CoV-2 NSP13 interacts with host IRF3, blocking antiviral immune responses.
Feng K, Zhang HJ, Min YQ, Zhou M, Deng F, Wang HL, Li PQ, Ning YJ.

Pellino3 ligase negatively regulates influenza B dependent RIG-I signalling through downregulation of TRAF3-mediated induction of the transcription factor IRF3 and IFNβ production.
Kula A, Makuch E, Lisowska M, Reniewicz P, Lipiński T, Siednienko J.

Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection.
Duncan JKS, Xu D, Licursi M, Joyce MA, Saffran HA, Liu K, Gohda J, Tyrrell DL, Kawaguchi Y, Hirasawa K., Free PMC Article

Roles of interferon regulatory factor 3 in skin inflammation: Possible involvement of regulatory mechanisms.
Tamagawa-Mineoka R, Ueta M, Arakawa Y, Nakanishi M, Nishigaki H, Katoh N.

Genetic Polymorphism in Toll-Like Receptor 3 and Interferon Regulatory Factor 3 in Hepatitis C Virus-Infected Patients: Correlation with Liver Cirrhosis.
Talaat RM, Elsayed SS, Abdel-Hakem NE, El-Shenawy SZ.

Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway.
Naik NG, Lee SC, Veronese BHS, Ma Z, Toth Z., Free PMC Article

SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4(+) T cells.
Kanno T, Miyako K, Nakajima T, Yokoyama S, Sasamoto S, Asou HK, Ohara O, Nakayama T, Endo Y., Free PMC Article

NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production.
Cai Y, Zhu Y, Zheng J, Zhang Y, Chen W.