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    IRF4 interferon regulatory factor 4 [ Homo sapiens (human) ]

    Gene ID: 3662, updated on 13-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Interferon-induced protein 44 (IFI44) and interferon regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis.

    Interferon-induced protein 44 (IFI44) and interferon regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis.
    Elsayed Ramadan Genena S, Hamouda MAF, Salama NM, Zahran ES, Abdel Latif AA, Dawood AA.

    09/12/2024
    IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression.

    IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression.
    Hirsch T, Neyens D, Duhamel C, Bayard A, Vanhaver C, Luyckx M, Sala de Oyanguren F, Wildmann C, Dauguet N, Squifflet JL, Montiel V, Deschamps M, van der Bruggen P.

    07/31/2024
    Clinical boundaries in adult cases of large B cell lymphoma with IRF4 rearrangement.

    Clinical boundaries in adult cases of large B cell lymphoma with IRF4 rearrangement.
    Maguire J, Harvey H, Jones A, Law R, Bashir M, O'Brien O, Sargent J, Grant C, Flavin R.

    12/28/2023
    Transcriptional reprogramming by mutated IRF4 in lymphoma.

    Transcriptional reprogramming by mutated IRF4 in lymphoma.
    Schleussner N, Cauchy P, Franke V, Giefing M, Fornes O, Vankadari N, Assi SA, Costanza M, Weniger MA, Akalin A, Anagnostopoulos I, Bukur T, Casarotto MG, Damm F, Daumke O, Edginton-White B, Gebhardt JCM, Grau M, Grunwald S, Hansmann ML, Hartmann S, Huber L, Kärgel E, Lusatis S, Noerenberg D, Obier N, Pannicke U, Fischer A, Reisser A, Rosenwald A, Schwarz K, Sundararaj S, Weilemann A, Winkler W, Xu W, Lenz G, Rajewsky K, Wasserman WW, Cockerill PN, Scheidereit C, Siebert R, Küppers R, Grosschedl R, Janz M, Bonifer C, Mathas S., Free PMC Article

    11/14/2023
    Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.

    Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.
    Wang G, Feng X, Ding J.

    11/10/2023
    Human inborn errors of immunity associated with IRF4.

    Human inborn errors of immunity associated with IRF4.
    Thouenon R, Kracker S., Free PMC Article

    11/6/2023
    NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.

    NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.
    López-López S, Romero de Ávila MJ, González-Gómez MJ, Nueda ML, Baladrón V, Monsalve EM, García-Ramírez JJ, Díaz-Guerra MJM.

    10/11/2023
    Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.

    Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
    Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L., Free PMC Article

    10/5/2023
    MUM-1 in canine lymphoma: A pilot study.

    MUM-1 in canine lymphoma: A pilot study.
    Riccardi E, Klopfleish R, Bell F, Calvez SL, Dawson LJ.

    05/5/2023
    Prevalence of IRF4 rearrangement in large B-cell lymphomas of the Waldeyer's ring in adults.

    Prevalence of IRF4 rearrangement in large B-cell lymphomas of the Waldeyer's ring in adults.
    Streich S, Frauenfeld L, Otto F, Mankel B, Bonzheim I, Fend F, Quintanilla-Martinez L., Free PMC Article

    03/31/2023
    A neomorphic mutation in the interferon activation domain of IRF4 causes a dominant primary immunodeficiency.

    A neomorphic mutation in the interferon activation domain of IRF4 causes a dominant primary immunodeficiency.
    Thouenon R, Chentout L, Moreno-Corona N, Poggi L, Lombardi EP, Hoareau B, Schmitt Y, Lagresle-Peyrou C, Bustamante J, André I, Cavazzana M, Durandy A, Casanova JL, Galicier L, Fadlallah J, Fischer A, Kracker S., Free PMC Article

    03/21/2023
    IRF4 as a novel target involved in malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma.

    IRF4 as a novel target involved in malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma.
    Meng L, Jiang Y, You J, Zhao P, Liu W, Zhao N, Yu Z, Ma J., Free PMC Article

    02/22/2023
    IRF4 Gene Expression on the Trail of Molecular Response: Looking at Chronic Myeloid Leukemia from Another Perspective.

    IRF4 Gene Expression on the Trail of Molecular Response: Looking at Chronic Myeloid Leukemia from Another Perspective.
    Tarantini F, Cumbo C, Parciante E, Anelli L, Zagaria A, Coccaro N, Minervini CF, Tota G, Redavid I, Conserva MR, Attolico I, Rossi AR, Specchia G, Musto P, Albano F.

    02/11/2023
    Interferon Regulatory Factor 4 (IRF4) Promotes Lipopolysaccharide-Induced Colonic Mucosal Epithelial Cell Proliferation by Regulating Macrophage Polarization.

    Interferon Regulatory Factor 4 (IRF4) Promotes Lipopolysaccharide-Induced Colonic Mucosal Epithelial Cell Proliferation by Regulating Macrophage Polarization.
    Hu L, Li S, Li H, Lai B, Wen H.

    02/4/2023
    A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.

    A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
    IRF4 International Consortium, Fornes O, Jia A, Kuehn HS, Min Q, Pannicke U, Schleussner N, Thouenon R, Yu Z, de Los Angeles Astbury M, Biggs CM, Galicchio M, Garcia-Campos JA, Gismondi S, Gonzalez Villarreal G, Hildebrand KJ, Hönig M, Hou J, Moshous D, Pittaluga S, Qian X, Rozmus J, Schulz AS, Staines-Boone AT, Sun B, Sun J, Uwe S, Venegas-Montoya E, Wang W, Wang X, Ying W, Zhai X, Zhou Q, Akalin A, André I, Barth TFE, Baumann B, Brüstle A, Burgio G, Bustamante JC, Casanova JL, Casarotto MG, Cavazzana M, Chentout L, Cockburn IA, Costanza M, Cui C, Daumke O, Del Bel KL, Eibel H, Feng X, Franke V, Gebhardt JCM, Götz A, Grunwald S, Hoareau B, Hughes TR, Jacobsen EM, Janz M, Jolma A, Lagresle-Peyrou C, Lai N, Li Y, Lin S, Lu HY, Lugo-Reyes SO, Meng X, Möller P, Moreno-Corona N, Niemela JE, Novakovsky G, Perez-Caraballo JJ, Picard C, Poggi L, Puig-Lombardi ME, Randall KL, Reisser A, Schmitt Y, Seneviratne S, Sharma M, Stoddard J, Sundararaj S, Sutton H, Tran LQ, Wang Y, Wasserman WW, Wen Z, Winkler W, Xiong E, Yang AWH, Yu M, Zhang L, Zhang H, Zhao Q, Zhen X, Enders A, Kracker S, Martinez-Barricarte R, Mathas S, Rosenzweig SD, Schwarz K, Turvey SE, Wang JY., Free PMC Article

    02/4/2023
    Large B-cell lymphoma with IRF4 gene rearrangements: Differences in clinicopathologic, immunophenotypic and cytogenetic features between pediatric and adult patients.

    Large B-cell lymphoma with IRF4 gene rearrangements: Differences in clinicopathologic, immunophenotypic and cytogenetic features between pediatric and adult patients.
    Berg HE, Peterson JF, Lee HE, McPhail ED.

    01/21/2023
    IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.

    IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.
    Das Gupta D, Paul C, Samel N, Bieringer M, Staudenraus D, Marini F, Raifer H, Menke L, Hansal L, Camara B, Roth E, Daum P, Wanzel M, Mernberger M, Nist A, Bauer UM, Helmprobst F, Buchholz M, Roth K, Bastian L, Hartmann AM, Baldus C, Ikuta K, Neubauer A, Burchert A, Jäck HM, Klein M, Bopp T, Stiewe T, Pagenstecher A, Lohoff M., Free PMC Article

    11/5/2022
    Unraveling the Structure-Dependent Inhibitory Effects of Ginsenoside Series Compounds on Human Cytochrome P450 1B1.

    Unraveling the Structure-Dependent Inhibitory Effects of Ginsenoside Series Compounds on Human Cytochrome P450 1B1.
    Zhao T, Chen X, Yu H, Du J, Wang D, Wang C, Meng Q, Sun H, Liu K, Wu J.

    10/29/2022
    Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis.

    Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis.
    Tang TF, Chan YT, Cheong HC, Cheok YY, Anuar NA, Looi CY, Gan GG, Wong WF.

    10/1/2022
    IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia.

    IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia.
    Huang X, Ma T, Zhu Y, Jiao B, Yu S, Wang K, Mi JQ, Ren R.

    07/30/2022
    Circ_0020123 regulates autophagy, glycolysis, and malignancy by upregulating IRF4 through eliminating miR-193a-3p-mediated suppression of IRF4 in non-small cell lung cancer.

    Circ_0020123 regulates autophagy, glycolysis, and malignancy by upregulating IRF4 through eliminating miR-193a-3p-mediated suppression of IRF4 in non-small cell lung cancer.
    Yang XP, Zheng YZ, Tan J, Tian RJ, Shen P, Cai WJ, Liao HY.

    07/9/2022
    Correlation of the transcription factors IRF4 and BACH2 with the abnormal NFATC1 expression in T cells from chronic myeloid leukemia patients.

    Correlation of the transcription factors IRF4 and BACH2 with the abnormal NFATC1 expression in T cells from chronic myeloid leukemia patients.
    Zhang Y, Zeng X, Zha X, Lai J, Tan G, Chen S, Yu X, Li Y, Xu L.

    05/21/2022
    Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells.

    Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells.
    Bristol JA, Brand J, Ohashi M, Eichelberg MR, Casco A, Nelson SE, Hayes M, Romero-Masters JC, Baiu DC, Gumperz JE, Johannsen EC, Dinh HQ, Kenney SC., Free PMC Article

    05/14/2022
    Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population.

    Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population.
    Melo APC, Teixeira HMP, Coelho RS, De Jesus TDS, Queiroz GA, Silva HDS, De Almeida YCF, Alcantara-Neves NM, De Matos SMA, D'innocenzo S, Silva RCR, Lima Barreto M, Costa RDS, Pinto LC, Figueiredo CA.

    05/14/2022
    Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements.

    Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements.
    Frauenfeld L, Castrejon-de-Anta N, Ramis-Zaldivar JE, Streich S, Salmerón-Villalobos J, Otto F, Mayer AK, Steinhilber J, Pinyol M, Mankel B, Ramsower C, Bonzheim I, Fend F, Rimsza LM, Salaverria I, Campo E, Balagué O, Quintanilla-Martinez L., Free PMC Article

    04/23/2022
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