| The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5. | The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5.
Maven BEJ, Gifford CA, Weilert M, Gonzalez-Teran B, Hüttenhain R, Pelonero A, Ivey KN, Samse-Knapp K, Kwong W, Gordon D, McGregor M, Nishino T, Okorie E, Rossman S, Costa MW, Krogan NJ, Zeitlinger J, Srivastava D., Free PMC Article | 11/30/2023 |
| Human breast milk cells are positive for the pioneer transcription factor ISL1. | Human breast milk cells are positive for the pioneer transcription factor ISL1.
Piras M, Coni P, Piludu M, Coni S, Lachowicz JI, Jaremko M, Faa G, Cau F, Scano A, Orrù G, Murru R, Pichiri G. | 11/1/2023 |
| Isl1 promotes gene transcription through physical interaction with Set1/Mll complexes. | Isl1 promotes gene transcription through physical interaction with Set1/Mll complexes.
Liu Z, Hu W, Qin Y, Sun L, Jing L, Lu M, Li Y, Qu J, Yang Z. | 08/24/2023 |
| Genetic Variants of ISL1 Gene Promoter Identified from Congenital Tetralogy of Fallot Patients Alter Cellular Function Forming Disease Basis. | Genetic Variants of ISL1 Gene Promoter Identified from Congenital Tetralogy of Fallot Patients Alter Cellular Function Forming Disease Basis.
Yin XY, Chen HX, Chen Z, Yang Q, Han J, He GW., Free PMC Article | 03/1/2023 |
| Identification and functional analysis of genetic variants of ISL1 gene promoter in human atrial septal defects. | Identification and functional analysis of genetic variants of ISL1 gene promoter in human atrial septal defects.
Yin XY, Chen HX, Chen Z, Yang Q, Han J, He GW. | 12/17/2022 |
| ISL1 Promotes Human Glioblastoma-Derived Stem Cells' Self-Renewal by Activation of Sonic Hedgehog/GLI1 Function. | ISL1 Promotes Human Glioblastoma-Derived Stem Cells' Self-Renewal by Activation of Sonic Hedgehog/GLI1 Function.
Liu Y, Luan Y, Ma K, Zhang Z, Liu Y, Chen X. | 05/21/2022 |
| Investigation of promoter methylation patterns association with genes expression profile of ISL1, MGMT and DMNT3b in tissue of breast cancer patients. | Investigation of promoter methylation patterns association with genes expression profile of ISL1, MGMT and DMNT3b in tissue of breast cancer patients.
Yari H, Shabani S, Nafissi N, Majidzadeh T, Mahjoubi F. | 04/2/2022 |
| ISL1 promotes enzalutamide resistance in castration-resistant prostate cancer (CRPC) through epithelial to mesenchymal transition (EMT). | ISL1 promotes enzalutamide resistance in castration-resistant prostate cancer (CRPC) through epithelial to mesenchymal transition (EMT).
Choi JD, Kim TJ, Jeong BC, Jeon HG, Jeon SS, Kang MY, Yeom SY, Seo SI., Free PMC Article | 01/29/2022 |
| Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer. | Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer.
Shi Q, Ni X, Lei M, Xia Q, Dong Y, Zhang Q, Wang W., Free PMC Article | 01/15/2022 |
| ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma. | ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma.
Li M, Sun C, Bu X, Que Y, Zhang L, Zhang Y, Zhang L, Lu S, Huang J, Zhu J, Wang J, Sun F, Zhang Y., Free PMC Article | 11/6/2021 |
| Association of ISL1 polymorphisms and eosinophilic levels among otitis media patients. | Association of ISL1 polymorphisms and eosinophilic levels among otitis media patients.
Kondyarpu A, Ray CS, Panda KC, Biswal NC, Ramchander PV., Free PMC Article | 11/6/2021 |
| Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4. | Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4.
Guo T, Bai YH, Cheng XJ, Han HB, Du H, Hu Y, Jia SQ, Xing XF, Ji JF., Free PMC Article | 10/23/2021 |
| Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation. | Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation.
Solomon E, Davis-Anderson K, Hovde B, Micheva-Viteva S, Harris JF, Twary S, Iyer R., Free PMC Article | 10/16/2021 |
| Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects. | Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects.
Zheng SQ, Chen HX, Liu XC, Yang Q, He GW. | 09/25/2021 |
| Expression of ISL1 and its partners in prostate cancer progression and neuroendocrine differentiation. | Expression of ISL1 and its partners in prostate cancer progression and neuroendocrine differentiation.
Alshalalfa M, Abou-Ouf H, Davicioni E, Karnes RJ, Alhajj R, Bismar TA. | 07/10/2021 |
| No association between POU4F1, POU4F2, ISL1 polymorphisms and normal-tension glaucoma. | No association between POU4F1, POU4F2, ISL1 polymorphisms and normal-tension glaucoma.
Lee JS, Jeoung JW, Oh S, Kim DM, Ahn JH, Kim MJ, Seong MW, Park SS, Kim JY. | 06/26/2021 |
| Overexpression of Isl1 under the Pax2 Promoter, Leads to Impaired Sound Processing and Increased Inhibition in the Inferior Colliculus. | Overexpression of Isl1 under the Pax2 Promoter, Leads to Impaired Sound Processing and Increased Inhibition in the Inferior Colliculus.
Chumak T, Tothova D, Filova I, Bures Z, Popelar J, Pavlinkova G, Syka J., Free PMC Article | 06/5/2021 |
| ISL1 loss-of-function variation causes familial atrial fibrillation. | ISL1 loss-of-function variation causes familial atrial fibrillation.
Wu SH, Wang XH, Xu YJ, Gu JN, Yang CX, Qiao Q, Guo XJ, Guo YH, Qiu XB, Jiang WF, Yang YQ. | 05/1/2021 |
| microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway. | microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway.
Sun Q, Zeng J, Liu Y, Chen J, Zeng QC, Chen YQ, Tu LL, Chen P, Yang F, Zhang M., Free PMC Article | 03/13/2021 |
| Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors. | Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors.
Sepehrimanesh M, Ding B., Free PMC Article | 12/19/2020 |
| [Discovery and functional analysis of a novel ISL1 variant associated with congenital heart defect]. | [Discovery and functional analysis of a novel ISL1 variant associated with congenital heart defect].
Dong B, Liu X, Wang T, Yang Y. | 11/21/2020 |
| The Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate.
Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G., Free PMC Article | 09/12/2020 |
| Heterozygous ISL1 nonsense mutation contributes to the pathogenesis of dilated cardiomyopathy. | Identification and Functional Characterization of an ISL1 Mutation Predisposing to Dilated Cardiomyopathy.
Xu YJ, Wang ZS, Yang CX, Di RM, Qiao Q, Li XM, Gu JN, Guo XJ, Yang YQ. | 05/23/2020 |
| Paper uncovers a molecular mechanism of ISL1 promoting metastasis of GC through binding to the ZEB1 promoter together with co-factor SETD7. | ISL1 predicts poor outcomes for patients with gastric cancer and drives tumor progression through binding to the ZEB1 promoter together with SETD7.
Guo T, Wen XZ, Li ZY, Han HB, Zhang CG, Bai YH, Xing XF, Cheng XJ, Du H, Hu Y, Wang XH, Jia YN, Nie ML, Xie M, Li QD, Ji JF., Free PMC Article | 04/4/2020 |
| Focusing on ISL1 and PLAGL1 the authors found no statistically significant differences in methylation status at these loci between patients and control samples. However, 20 CpGs in PLAGL1 and 19 CpGs in ISL1 showed at least 25% increase or decrease of DNA methylation. | Classic bladder exstrophy and adenocarcinoma of the bladder: Methylome analysis provide no evidence for underlying disease-mechanisms of this association.
Sharma A, Fröhlich H, Zhang R, Ebert AK, Rösch W, Reis H, Kristiansen G, Ellinger J, Reutter H. | 03/7/2020 |