| Integrin-alpha9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia. | Integrin-α9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia.
Niibori-Nambu A, Wang CQ, Chin DWL, Chooi JY, Hosoi H, Sonoki T, Tham CY, Nah GSS, Cirovic B, Tan DQ, Takizawa H, Sashida G, Goh Y, Tng J, Fam WN, Fullwood MJ, Suda T, Yang H, Tergaonkar V, Taniuchi I, Li S, Chng WJ, Osato M. | 09/26/2024 |
| ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells. | ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells.
Liu W, Fang S, Yang Z, Ma J, Tan Y, Chen Y, Zhang K, Liu K, Gu W. | 02/1/2024 |
| Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population. | Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population.
Xin Q, Xin G, Li L, Sun W, Jiang W, Wang J, Luan Y, Zhang Y, Cheng L, Duan S, Hong F, Ji Q, Ma W. | 11/26/2022 |
| Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma. | Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma.
Navarro N, Molist C, Sansa-Girona J, Zarzosa P, Gallo-Oller G, Pons G, Magdaleno A, Guillén G, Hladun R, Garrido M, Segura MF, Hontecillas-Prieto L, de Álava E, Ponsati B, Fernández-Carneado J, Almazán-Moga A, Vallès-Miret M, Farrera-Sinfreu J, de Toledo JS, Moreno L, Gallego S, Roma J., Free PMC Article | 10/15/2022 |
| ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors. | ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors.
Wu Y, Chen J, Tan F, Wang B, Xu W, Yuan C. | 08/27/2022 |
| Tenascin-C regulates migration of SOX10 tendon stem cells via integrin-alpha9 for promoting patellar tendon remodeling. | Tenascin-C regulates migration of SOX10 tendon stem cells via integrin-α9 for promoting patellar tendon remodeling.
Xu K, Shao Y, Xia Y, Qian Y, Jiang N, Liu X, Yang L, Wang C. | 02/19/2022 |
| Integrin-alpha9 and Its Corresponding Ligands Play Regulatory Roles in Chronic Periodontitis. | Integrin-α9 and Its Corresponding Ligands Play Regulatory Roles in Chronic Periodontitis.
Xu S, Jiang C, Liu H, Zhang H, Liao H, Wang X, Yao S, Ma L, Guo Y, Cao Z. | 06/12/2021 |
| Integrin alpha9 is involved in the pathopoiesis of acute aortic dissection via mediating phenotype switch of vascular smooth muscle cell. | Integrin α9 is involved in the pathopoiesis of acute aortic dissection via mediating phenotype switch of vascular smooth muscle cell.
Huang B, Niu Y, Chen Z, Yang Y, Wang X. | 03/20/2021 |
| miR-148a can suppress the malignant phenotype of glioblastoma by targeting ITGA9 and identify ITGA9 as a potential therapeutic target for glioblastoma. | MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9.
Xu TJ, Qiu P, Zhang YB, Yu SY, Xu GM, Yang W. | 02/29/2020 |
| ITGA9 level is significantly higher in triple-negative breast cancer (TNBC) than other breast cancer subtypes. Hhigher ITGA9 level is associated with significantly worse metastasis- and recurrence-free survival. Experimentally, ITGA9 KO significantly reduced TNBC cell cancer stem cell-like property, tumor angiogenesis, tumor growth and metastasis by promoting beta-catenin degradation through ILK/PKA/GSK3 pathway. | Integrin α9 depletion promotes β-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis.
Wang Z, Li Y, Xiao Y, Lin HP, Yang P, Humphries B, Gao T, Yang C., Free PMC Article | 02/22/2020 |
| This review summarises the known shared and specific roles for alpha4 and alpha9 integrins and highlights the importance of these receptors in controlling cell migration within both homeostatic and disease settings. | Regulation of cell migration by α4 and α9 integrins.
Hight-Warburton W, Parsons M. | 12/21/2019 |
| rs2212020 and rs189897 polymorphisms of the ITGA9 gene is associated with epithelial ovarian cancer. | Clinical relationships between the rs2212020 and rs189897 polymorphisms of the ITGA9 gene and epithelial ovarian cancer.
Liu J, Liu T, Liang L, He J, Zhang M, Ge Y, Liao S, Zhou Y, Zhang K. | 07/13/2019 |
| ITGA9 expression was found to be increased in the suprabasal psoriatic epidermis. | miR-4516, a microRNA downregulated in psoriasis inhibits keratinocyte motility by targeting fibronectin/integrin α9 signaling.
Chowdhari S, Sardana K, Saini N. | 12/22/2018 |
| Our data suggest ITGA9, as a suppressor of HCC, prevents tumor cell migration and invasiveness through FAK/Src-Rac1/RhoA signaling. | Integrin α9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling.
Zhang YL, Xing X, Cai LB, Zhu L, Yang XM, Wang YH, Yang Q, Nie HZ, Zhang ZG, Li J, Zhang XL., Free PMC Article | 10/20/2018 |
| this study demonstrates the central role of alpha9 in pathogenic behaviors of rheumatoid arthritis fibroblast-like synoviocytes | Constitutive Activation of Integrin α9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis.
Emori T, Hirose J, Ise K, Yomoda JI, Kasahara M, Shinkuma T, Yoshitomi H, Ito H, Hashimoto M, Sugahara S, Fujita H, Yamamoto N, Morita Y, Narumiya S, Aramori I., Free PMC Article | 11/26/2017 |
| Metastatic prostate cancer cells cultured on osteo-mimetic surfaces coated with tenascin C exhibited enhanced adhesion and colony formation as mediated by integrin alpha9beta1. | Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment.
San Martin R, Pathak R, Jain A, Jung SY, Hilsenbeck SG, Piña-Barba MC, Sikora AG, Pienta KJ, Rowley DR., Free PMC Article | 11/25/2017 |
| findings identify a novel physiological context for combinatorial integrin signaling, laying the foundation for therapeutic strategies that manipulate alpha9beta1 and/or alpha3beta1 during wound healing | Suppression of integrin α3β1 by α9β1 in the epidermis controls the paracrine resolution of wound angiogenesis.
Longmate WM, Lyons SP, Chittur SV, Pumiglia KM, Van De Water L, DiPersio CM., Free PMC Article | 10/7/2017 |
| the expression levels of DLEC1 and ITGA9 were prominently decreased in lung tumor samples | Expression level and methylation status of three tumor suppressor genes, DLEC1, ITGA9 and MLH1, in non-small cell lung cancer.
Pastuszak-Lewandoska D, Kordiak J, Antczak A, Migdalska-Sęk M, Czarnecka KH, Górski P, Nawrot E, Kiszałkiewicz JM, Domańska-Senderowska D, Brzeziańska-Lasota E. | 04/22/2017 |
| our results demonstrate that upregulation of ITGA9 in response to the decrease in miR-125b in metastatic melanoma is responsible for melanoma tumor cell migration and invasion. | MicroRNA-125b suppresses the epithelial-mesenchymal transition and cell invasion by targeting ITGA9 in melanoma.
Zhang J, Na S, Liu C, Pan S, Cai J, Qiu J. | 02/18/2017 |
| ITGA9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma. | Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma.
Nawaz I, Hu LF, Du ZM, Moumad K, Ignatyev I, Pavlova TV, Kashuba V, Almgren M, Zabarovsky ER, Ernberg I., Free PMC Article | 08/27/2016 |
| p75(NTR) and alpha9 integrin subunit are not closely associated through their cytoplasmic domains, most probably because of the molecular interference with other cytoplasmic proteins such as paxillin. | Association of p75(NTR) and α9β1 integrin modulates NGF-dependent cellular responses.
Ventresca EM, Lecht S, Jakubowski P, Chiaverelli RA, Weaver M, Del Valle L, Ettinger K, Gincberg G, Priel A, Braiman A, Lazarovici P, Lelkes PI, Marcinkiewicz C., Free PMC Article | 12/26/2015 |
| alpha9beta1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis. | α9β1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis.
Asano T, Iwasaki N, Kon S, Kanayama M, Morimoto J, Minami A, Uede T. | 06/7/2014 |
| rs189897 and rs2212020 genotypes of the ITGA9 are closely related to cerebral infarction, and the A-C haplotype is a protective factor against cerebral infarction. | [Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction].
Li XM, Li J, Zeng F, Yi H. | 04/20/2013 |
| integrin alpha9beta1 is expressed in primary small cell lung cancer and patients having a high expression of alpha9beta1 demonstrated significantly worse long-term survival compared with patients with low alpha9beta1 expression | Integrin α9β1 promotes malignant tumor growth and metastasis by potentiating epithelial-mesenchymal transition.
Gupta SK, Oommen S, Aubry MC, Williams BP, Vlahakis NE., Free PMC Article | 03/9/2013 |
| Neuronal cadherin and alpha9-integrin are postulated as leading actors in the association between the Notch pathway and promotion of cell adhesion, motility and invasion in rhabdomyosarcoma cells | Notch-mediated induction of N-cadherin and α9-integrin confers higher invasive phenotype on rhabdomyosarcoma cells.
Masià A, Almazán-Moga A, Velasco P, Reventós J, Torán N, Sánchez de Toledo J, Roma J, Gallego S., Free PMC Article | 12/22/2012 |