| Cryo-EM structure of I domain-containing integrin alphaEbeta7. | Cryo-EM structure of I domain-containing integrin αEβ7.
Akasaka H, Sato D, Shihoya W, Nureki O, Kise Y. | 06/14/2024 |
| Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity. | Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.
Hamid MHBA, Cespedes PF, Jin C, Chen JL, Gileadi U, Antoun E, Liang Z, Gao F, Teague R, Manoharan N, Maldonado-Perez D, Khalid-Alham N, Cerundolo L, Ciaoca R, Hester SS, Pinto-Fernández A, Draganov SD, Vendrell I, Liu G, Yao X, Kvalvaag A, Dominey-Foy DCC, Nanayakkara C, Kanellakis N, Chen YL, Waugh C, Clark SA, Clark K, Sopp P, Rahman NM, Verrill C, Kessler BM, Ogg G, Fernandes RA, Fisher R, Peng Y, Dustin ML, Dong T., Free PMC Article | 05/22/2024 |
| CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden. | CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.
van den Bulk J, van der Ploeg M, Ijsselsteijn ME, Ruano D, van der Breggen R, Duhen R, Peeters KCMJ, Fariña-Sarasqueta A, Verdegaal EME, van der Burg SH, Duhen T, de Miranda NFCC., Free PMC Article | 02/22/2023 |
| The tissue-resident marker CD103 on peripheral blood T cells predicts responses to anti-PD-1 therapy in gastric cancer. | The tissue-resident marker CD103 on peripheral blood T cells predicts responses to anti-PD-1 therapy in gastric cancer.
Nose Y, Saito T, Yamamoto K, Yamashita K, Tanaka K, Yamamoto K, Makino T, Takahashi T, Kawashima A, Haruna M, Hirata M, Ueyama A, Iwahori K, Satoh T, Kurokawa Y, Eguchi H, Doki Y, Wada H., Free PMC Article | 01/21/2023 |
| The multifunctional nature of CD103 (alphaEbeta7 integrin) signaling in tissue-resident lymphocytes. | The multifunctional nature of CD103 (αEβ7 integrin) signaling in tissue-resident lymphocytes.
Xu W, Bergsbaken T, Edelblum KL., Free PMC Article | 10/22/2022 |
| CD103 integrin identifies a high IL-10-producing FoxP3(+) regulatory T-cell population suppressing allergic airway inflammation. | CD103 integrin identifies a high IL-10-producing FoxP3(+) regulatory T-cell population suppressing allergic airway inflammation.
Tagkareli S, Salagianni M, Galani IE, Manioudaki M, Pavlos E, Thanopoulou K, Andreakos E. | 04/30/2022 |
| The differentiation of new human CD303(+) Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells. | The differentiation of new human CD303(+) Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells.
Zhong Q, Lu Y, Xu W, Rong Z, Chang X, Qin L, Chen X, Zhou F. | 01/22/2022 |
| Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade. | Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.
Banchereau R, Chitre AS, Scherl A, Wu TD, Patil NS, de Almeida P, Kadel Iii EE, Madireddi S, Au-Yeung A, Takahashi C, Chen YJ, Modrusan Z, McBride J, Nersesian R, El-Gabry EA, Robida MD, Hung JC, Kowanetz M, Zou W, McCleland M, Caplazi P, Eshgi ST, Koeppen H, Hegde PS, Mellman I, Mathews WR, Powles T, Mariathasan S, Grogan J, O'Gorman WE., Free PMC Article | 12/18/2021 |
| CD8+CD103+ tissue-resident memory T cells convey reduced protective immunity in cutaneous squamous cell carcinoma. | CD8+CD103+ tissue-resident memory T cells convey reduced protective immunity in cutaneous squamous cell carcinoma.
Lai C, Coltart G, Shapanis A, Healy C, Alabdulkareem A, Selvendran S, Theaker J, Sommerlad M, Rose-Zerilli M, Al-Shamkhani A, Healy E., Free PMC Article | 12/18/2021 |
| KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease. | KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease.
Bottois H, Ngollo M, Hammoudi N, Courau T, Bonnereau J, Chardiny V, Grand C, Gergaud B, Allez M, Le Bourhis L., Free PMC Article | 04/13/2021 |
| Self-Maintaining CD103(+) Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses. | Self-Maintaining CD103(+) Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses.
Abd Hamid M, Colin-York H, Khalid-Alham N, Browne M, Cerundolo L, Chen JL, Yao X, Rosendo-Machado S, Waugh C, Maldonado-Perez D, Bowes E, Verrill C, Cerundolo V, Conlon CP, Fritzsche M, Peng Y, Dong T., Free PMC Article | 10/3/2020 |
| Intravenous CBD-CCL4 administration recruits CD103(+) DCs and CD8(+) T cells and improves the antitumor effect of CPI immunotherapy in multiple tumor models, including poor responders to CPI. | Recruitment of CD103(+) dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy.
Williford JM, Ishihara J, Ishihara A, Mansurov A, Hosseinchi P, Marchell TM, Potin L, Swartz MA, Hubbell JA., Free PMC Article | 06/6/2020 |
| Study data indicate that CD103 engages in dendritic cell (DC)-epithelial cell interactions upon contact with epithelial E-cadherin but is not a major driver of DC adhesion to gastrointestinal epithelia. | CD103 (αE Integrin) Undergoes Endosomal Trafficking in Human Dendritic Cells, but Does Not Mediate Epithelial Adhesion.
Swain S, Roe MM, Sebrell TA, Sidar B, Dankoff J, VanAusdol R, Smythies LE, Smith PD, Bimczok D., Free PMC Article | 10/26/2019 |
| CD103-expressing cancer stem cells exosomes acted to guide them to target cancer cells and organs, conferring the higher metastatic capacity of clear cell renal cell carcinoma to lungs. | CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p.
Wang L, Yang G, Zhao D, Wang J, Bai Y, Peng Q, Wang H, Fang R, Chen G, Wang Z, Wang K, Li G, Yang Y, Wang Z, Guo P, Peng L, Hou D, Xu W., Free PMC Article | 08/24/2019 |
| alphaE gene expression levels were significantly higher in ileal compared with colonic biopsies in both Crohn's disease and Ulcerative colitis, as well as in healthy subjects. | AlphaE Integrin Expression Is Increased in the Ileum Relative to the Colon and Unaffected by Inflammation.
Ichikawa R, Lamb CA, Eastham-Anderson J, Scherl A, Raffals L, Faubion WA, Bennett MR, Long AK, Mansfield JC, Kirby JA, Keir ME., Free PMC Article | 03/2/2019 |
| Indeterminate pediatric acute liver failure (iPALF) cases are characterized by a perforin+CD103+CD8+ T-cell predominant hepatic infiltrate consistent with expansion of a Trm CD8+ T-cell phenotype, which is clearly different from noninflammatory causes of PALF. | Indeterminate pediatric acute liver failure is uniquely characterized by a CD103(+) CD8(+) T-cell infiltrate.
Chapin CA, Burn T, Meijome T, Loomes KM, Melin-Aldana H, Kreiger PA, Whitington PF, Behrens EM, Alonso EM. | 03/2/2019 |
| FGL2 promotes tumor progression in the brain by suppressing CD103-expressing dendritic cell differentiation. | FGL2 promotes tumor progression in the CNS by suppressing CD103(+) dendritic cell differentiation.
Yan J, Zhao Q, Gabrusiewicz K, Kong LY, Xia X, Wang J, Ott M, Xu J, Davis RE, Huo L, Rao G, Sun SC, Watowich SS, Heimberger AB, Li S., Free PMC Article | 02/16/2019 |
| ITGAE+ lymphocytes tended to associate with the epithelial-mesenchymal transition (EMT) with decreased Snail and increased E-cadherin expression accompanied. | ITGAE Defines CD8+ Tumor-Infiltrating Lymphocytes Predicting a better Prognostic Survival in Colorectal Cancer.
Hu X, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ., Free PMC Article | 01/26/2019 |
| Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. | Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.
Duhen T, Duhen R, Montler R, Moses J, Moudgil T, de Miranda NF, Goodall CP, Blair TC, Fox BA, McDermott JE, Chang SC, Grunkemeier G, Leidner R, Bell RB, Weinberg AD., Free PMC Article | 12/22/2018 |
| Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8(+) T-cell migratory behavior and effector functions. | Paxillin Binding to the Cytoplasmic Domain of CD103 Promotes Cell Adhesion and Effector Functions for CD8(+) Resident Memory T Cells in Tumors.
Gauthier L, Corgnac S, Boutet M, Gros G, Validire P, Bismuth G, Mami-Chouaib F. | 01/6/2018 |
| AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD. | Blockade of αEβ7 integrin suppresses accumulation of CD8(+) and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.
Zundler S, Schillinger D, Fischer A, Atreya R, López-Posadas R, Watson A, Neufert C, Atreya I, Neurath MF. | 10/21/2017 |
| The CD103+CD4+/CD4+ ratio does not accurately discriminate between sarcoidosis and other causes of lymphocytic alveolitis, neither alone nor in combination with the CD4+/CD8+ ratio, and is not a powerful marker for the diagnosis of sarcoidosis. | Diagnostic Value of the CD103+CD4+/CD4+ Ratio to Differentiate Sarcoidosis from Other Causes of Lymphocytic Alveolitis.
Bretagne L, Diatta ID, Faouzi M, Nobile A, Bongiovanni M, Nicod LP, Lazor R. | 09/16/2017 |
| CD103 expression in human dendritic cells is regulated differentially by retinoic acid and Toll-like receptor ligands. | Differential regulation of CD103 (αE integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands.
Roe MM, Swain S, Sebrell TA, Sewell MA, Collins MM, Perrino BA, Smith PD, Smythies LE, Bimczok D., Free PMC Article | 09/9/2017 |
| detected CD103 tumor cells in 41% (16/39) of lymph node-involved adult T-cell leukemia/lymphoma | High Expression of Intestinal Homing Receptor CD103 in Adult T-Cell Leukemia/Lymphoma, Similar to 2 Other CD8+ T-Cell Lymphomas.
Ishibashi H, Nimura S, Ishitsuka K, Mihashi Y, Mizoguchi M, Nakamura S, Okamura S, Momosaki S, Aoyagi K, Sakisaka S, Takeshita M. | 08/6/2016 |
| Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients. | Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis.
Tew GW, Hackney JA, Gibbons D, Lamb CA, Luca D, Egen JG, Diehl L, Eastham Anderson J, Vermeire S, Mansfield JC, Feagan BG, Panes J, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Kirby JA, Irving PM, De Hertogh G, Van Assche GA, Rutgeerts P, O'Byrne S, Hayday A, Keir ME. | 06/4/2016 |