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    ITGB2 integrin subunit beta 2 [ Homo sapiens (human) ]

    Gene ID: 3689, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia.

    Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia.
    Xie H, Jiang Y, Xiang Y, Wu B, Zhao J, Huang R, Wang M, Wang Y, Liu J, Wu D, Tian D, Bian E.,

    09/11/2024
    ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures.

    ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures.
    Li J, Cao D, Jiang L, Zheng Y, Shao S, Zhuang A, Xiang D.

    07/24/2024
    Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.

    Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.
    Budzyń M, Gryszczyńska B, Begier-Krasińska B, Kaja E, Mikołajczak P, Kujawski R, Grupińska J, Iskra M, Tykarski A, Kaczmarek M.

    02/8/2024
    Identification of an association between coronary heart disease and ITGB2 methylation in peripheral blood by a case-control study.

    Identification of an association between coronary heart disease and ITGB2 methylation in peripheral blood by a case-control study.
    Zhu L, Zhu C, Jin J, Wang J, Zhao X, Yang R.

    12/27/2023
    Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.

    Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.
    Díaz-Alvarez L, Martínez-Sánchez ME, Gray E, Pérez-Figueroa E, Ortega E., Free PMC Article

    11/1/2023
    Characterization of tumor microenvironment in glioblastoma multiforme identifies ITGB2 as a key immune and stromal related regulator in glial cell types.

    Characterization of tumor microenvironment in glioblastoma multiforme identifies ITGB2 as a key immune and stromal related regulator in glial cell types.
    Sai Krishna AVS, Ramu A, Hariharan S, Sinha S, Donakonda S.

    09/29/2023
    Association of integrin-beta2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients.

    Association of integrin-β2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients.
    Selim AM, Elsabagh YA, El-Sawalhi MM, Ismail NA, Senousy MA., Free PMC Article

    09/6/2023
    Targeting Neutrophil beta2-Integrins: A Review of Relevant Resources, Tools, and Methods.

    Targeting Neutrophil β(2)-Integrins: A Review of Relevant Resources, Tools, and Methods.
    Conley HE, Sheats MK., Free PMC Article

    07/5/2023
    Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis.

    Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis.
    Hu Y, Yu Y, Dong H, Jiang W., Free PMC Article

    06/3/2023
    Correlation between ITGB2 expression and clinical characterization of glioma and the prognostic significance of its methylation in low-grade glioma(LGG).

    Correlation between ITGB2 expression and clinical characterization of glioma and the prognostic significance of its methylation in low-grade glioma(LGG).
    Liu H, Wang J, Luo T, Zhen Z, Liu L, Zheng Y, Zhang C, Hu X., Free PMC Article

    02/4/2023
    Soluble uric acid inhibits beta2 integrin-mediated neutrophil recruitment in innate immunity.

    Soluble uric acid inhibits β2 integrin-mediated neutrophil recruitment in innate immunity.
    Ma Q, Immler R, Pruenster M, Sellmayr M, Li C, von Brunn A, von Brunn B, Ehmann R, Wölfel R, Napoli M, Li Q, Romagnani P, Böttcher RT, Sperandio M, Anders HJ, Steiger S., Free PMC Article

    06/25/2022
    ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas.

    ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas.
    Xu H, Zhang A, Han X, Li Y, Zhang Z, Song L, Wang W, Lou M., Free PMC Article

    05/21/2022
    Magnesium sensing via LFA-1 regulates CD8(+) T cell effector function.

    Magnesium sensing via LFA-1 regulates CD8(+) T cell effector function.
    Lötscher J, Martí I Líndez AA, Kirchhammer N, Cribioli E, Giordano Attianese GMP, Trefny MP, Lenz M, Rothschild SI, Strati P, Künzli M, Lotter C, Schenk SH, Dehio P, Löliger J, Litzler L, Schreiner D, Koch V, Page N, Lee D, Grählert J, Kuzmin D, Burgener AV, Merkler D, Pless M, Balmer ML, Reith W, Huwyler J, Irving M, King CG, Zippelius A, Hess C.

    03/12/2022
    A novel ITGB2 variant with long survival in patients with leukocyte adhesion defect type-I.

    A novel ITGB2 variant with long survival in patients with leukocyte adhesion defect type-I.
    Celiksoy MH, Köker MY, Gezdirici A, Ozsoy S, Malbora B, Gungor S.

    02/5/2022
    LncRNA ITGB2-AS1 promotes the progression of clear cell renal cell carcinoma by modulating miR-328-5p/HMGA1 axis.

    LncRNA ITGB2-AS1 promotes the progression of clear cell renal cell carcinoma by modulating miR-328-5p/HMGA1 axis.
    Zhang W, Lu Y, Shi H, Li X, Zhang Z, Deng X, Yang Y, Wan B.

    01/1/2022
    Galectin-9 mediates neutrophil capture and adhesion in a CD44 and beta2 integrin-dependent manner.

    Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner.
    Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin-Williams SN, Voisin MB, Hussain MT, Law HL, Niki T, Hirashima M, Bombardieri M, Pitzalis C, Tiwari A, Nash GB, Norling LV, Cooper D.

    12/25/2021
    Biologia Futura: stories about the functions of beta2-integrins in human phagocytes.

    Biologia Futura: stories about the functions of β(2)-integrins in human phagocytes.
    Bajtay Z.

    12/11/2021
    Integrin beta1 Promotes Pancreatic Tumor Growth by Upregulating Kindlin-2 and TGF-beta Receptor-2.

    Integrin β1 Promotes Pancreatic Tumor Growth by Upregulating Kindlin-2 and TGF-β Receptor-2.
    Mia MS, Jarajapu Y, Rao R, Mathew S., Free PMC Article

    11/13/2021
    beta2 Integrin Gene (ITGB2) mutation spectra in Pakistani families with leukocyte adhesion deficiency type 1 (LAD1).

    β2 Integrin Gene (ITGB2) mutation spectra in Pakistani families with leukocyte adhesion deficiency type 1 (LAD1).
    Nawaz Tipu H, Raza R, Jaffar S, Khan A, Anwar MZ, Ahmad W, Raza SI.

    10/16/2021
    Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study.

    Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study.
    Lokki AI, Teirilä L, Triebwasser M, Daly E, Bhattacharjee A, Uotila L, Llort Asens M, Kurki MI, Perola M, Auro K, Salmon JE, Daly M, Atkinson JP, Laivuori H, Fagerholm S, Meri S, Finnpec., Free PMC Article

    09/18/2021
    Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin.

    Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin.
    Espinosa-Vinals CA, Masin J, Holubova J, Stanek O, Jurnecka D, Osicka R, Sebo P, Bumba L., Free PMC Article

    08/28/2021
    beta2-integrin LFA1 mediates airway damage following neutrophil transepithelial migration during respiratory syncytial virus infection.

    β(2)-integrin LFA1 mediates airway damage following neutrophil transepithelial migration during respiratory syncytial virus infection.
    Herbert JA, Deng Y, Hardelid P, Robinson E, Ren L, Moulding D, Smyth RL, Smith CM., Free PMC Article

    08/28/2021
    Complement receptor 3 mediates both sinking phagocytosis and phagocytic cup formation via distinct mechanisms.

    Complement receptor 3 mediates both sinking phagocytosis and phagocytic cup formation via distinct mechanisms.
    Walbaum S, Ambrosy B, Schütz P, Bachg AC, Horsthemke M, Leusen JHW, Mócsai A, Hanley PJ., Free PMC Article

    08/21/2021
    Moieties of Complement iC3b Recognized by the I-domain of Integrin alphaXbeta2.

    Moieties of Complement iC3b Recognized by the I-domain of Integrin αXβ2.
    Choi J, Buyannemekh D, Nham SU., Free PMC Article

    07/31/2021
    Identification of neutrophil beta2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses.

    Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses.
    Matsumoto K, Kurasawa T, Yoshimoto K, Suzuki K, Takeuchi T., Free PMC Article

    07/10/2021
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