| Somatic ARAF mutations in pediatric Langerhans cell histiocytosis: clinicopathologic, genetic and functional profiling. | Somatic ARAF mutations in pediatric Langerhans cell histiocytosis: clinicopathologic, genetic and functional profiling.
Liu R, Guo Y, Han L, Feng S, Cao J, Sun Y, Cao Z, Cui X. | 12/22/2023 |
| ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. | ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.
Su W, Mukherjee R, Yaeger R, Son J, Xu J, Na N, Merna Timaul N, Hechtman J, Paroder V, Lin M, Mattar M, Qiu J, Chang Q, Zhao H, Zhang J, Little M, Adachi Y, Han SW, Taylor BS, Ebi H, Abdel-Wahab O, de Stanchina E, Rudin CM, Jänne PA, McCormick F, Yao Z, Rosen N., Free PMC Article | 07/16/2022 |
| ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers. | ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers.
Mooz J, Riegel K, Ps H, Sadanandam A, Marini F, Klein M, Werner U, Roth W, Wilken-Schmitz A, Tegeder I, Rajalingam K., Free PMC Article | 04/16/2022 |
| ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma. | ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.
Yen I, Shanahan F, Lee J, Hong YS, Shin SJ, Moore AR, Sudhamsu J, Chang MT, Bae I, Dela Cruz D, Hunsaker T, Klijn C, Liau NPD, Lin E, Martin SE, Modrusan Z, Piskol R, Segal E, Venkatanarayan A, Ye X, Yin J, Zhang L, Kim JS, Lim HS, Kim KP, Kim YJ, Han HS, Lee SJ, Kim ST, Jung M, Hong YH, Noh YS, Choi M, Han O, Nowicka M, Srinivasan S, Yan Y, Kim TW, Malek S. | 12/25/2021 |
| Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway. | Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway.
Meng LD, Shi GD, Ge WL, Huang XM, Chen Q, Yuan H, Wu PF, Lu YC, Shen P, Zhang YH, Cao SJ, Miao Y, Tu M, Jiang KR. | 03/28/2021 |
| The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2, thus rendering cells susceptible to apoptosis | Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation.
Rauch J, Vandamme D, Mack B, McCann B, Volinsky N, Blanco A, Gires O, Kolch W., Free PMC Article | 01/13/2018 |
| This review discusses the regulation of A-Raf protein expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf inhibitors. [review] | A-Raf: A new star of the family of raf kinases.
An S, Yang Y, Ward R, Liu Y, Guo XX, Xu TR. | 09/10/2016 |
| analysis of FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma | Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma.
Sia D, Losic B, Moeini A, Cabellos L, Hao K, Revill K, Bonal D, Miltiadous O, Zhang Z, Hoshida Y, Cornella H, Castillo-Martin M, Pinyol R, Kasai Y, Roayaie S, Thung SN, Fuster J, Schwartz ME, Waxman S, Cordon-Cardo C, Schadt E, Mazzaferro V, Llovet JM. | 04/2/2016 |
| Aberrant expression of A-, B-, and C-RAF, and COT is frequent in PTC; increased expression of COT is correlated with recurrence of PTC. | Aberrant expression of COT is related to recurrence of papillary thyroid cancer.
Lee J, Jeong S, Park JH, Lee CR, Ku CR, Kang SW, Jeong JJ, Nam KH, Shin DY, Lee EJ, Chung WY, Jo YS., Free PMC Article | 04/25/2015 |
| Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration. | Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration.
Mooz J, Oberoi-Khanuja TK, Harms GS, Wang W, Jaiswal BS, Seshagiri S, Tikkanen R, Rajalingam K. | 04/4/2015 |
| The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis. | Somatic activating ARAF mutations in Langerhans cell histiocytosis.
Nelson DS, Quispel W, Badalian-Very G, van Halteren AG, van den Bos C, Bovée JV, Tian SY, Van Hummelen P, Ducar M, MacConaill LE, Egeler RM, Rollins BJ. | 07/19/2014 |
| Galpha12-ARAF-ERK pathway stimulates RFFL transcription through the transcription factor c-Myc. | Different Raf protein kinases mediate different signaling pathways to stimulate E3 ligase RFFL gene expression in cell migration regulation.
Gan X, Wang C, Patel M, Kreutz B, Zhou M, Kozasa T, Wu D., Free PMC Article | 02/8/2014 |
| show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 signals in vertebrate embryos by directly inhibiting Smad2 signalling | Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region.
Liu X, Xiong C, Jia S, Zhang Y, Chen YG, Wang Q, Meng A., Free PMC Article | 10/26/2013 |
| study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK pathway in cells treated with RAF inhibitors; ARAF seems to stabilize BRAF:CRAF complexes in cells treated with RAF inhibitors and regulate cell signaling in a subtle manner to ensure signaling efficiency | ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.
Rebocho AP, Marais R. | 09/7/2013 |
| Ras pathway activation via EGF treatment induced strong binding between B-Raf and C-Raf and a low level of binding between B-Raf and A-Raf. | Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.
Freeman AK, Ritt DA, Morrison DK., Free PMC Article | 04/20/2013 |
| hnRNP H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. | Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription.
Rauch J, O'Neill E, Mack B, Matthias C, Munz M, Kolch W, Gires O., Free PMC Article | 04/12/2010 |
| Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites. | Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.
Baljuls A, Schmitz W, Mueller T, Zahedi RP, Sickmann A, Hekman M, Rapp UR. | 01/21/2010 |
| A-Raf kinase is negatively regulated by trihydrophobin 1 | Trihydrophobin 1 is a new negative regulator of A-Raf kinase.
Liu W, Shen X, Yang Y, Yin X, Xie J, Yan J, Jiang J, Liu W, Wang H, Sun M, Zheng Y, Gu J. | 01/21/2010 |
| In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf. | Identification of TH1 as an interaction partner of A-Raf kinase.
Yin XL, Chen S, Gu JX. | 01/21/2010 |
| mutation analysis of the conserved regions in the ARAF gene in human colorectal adenocarcinoma | Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.
Fransén K, Klintenäs M, Osterström A, Dimberg J, Monstein HJ, Söderkvist P. | 01/21/2010 |
| A-Raf residues are identified that bind to specific phosphoinositides, possibly as a mechanism to localize the enzyme to particular membrane microdomains rich in these phospholipids. | Identification of key residues in the A-Raf kinase important for phosphoinositide lipid binding specificity.
Johnson LM, James KM, Chamberlain MD, Anderson DH. | 01/21/2010 |
| These data reveal that B-RAF is an important mediator of neuronal survival, migration, and dendrite formation and that A-RAF cannot fully compensate for these functions. | Cortical migration defects in mice expressing A-RAF from the B-RAF locus.
Camarero G, Tyrsin OY, Xiang C, Pfeiffer V, Pleiser S, Wiese S, Götz R, Rapp UR., Free PMC Article | 01/21/2010 |
| A-Raf interacts with MEK1 and activates MEK1 by phosphorylation. | Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.
Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL. | 06/18/2003 |