| eIF6 Promotes Gastric Cancer Proliferation and Invasion by Regulating Cell Cycle. | eIF6 Promotes Gastric Cancer Proliferation and Invasion by Regulating Cell Cycle.
Huang CG, Zhou XQ, Zheng AF, Luo X, Shen J, Xiao ZG, Yang ZH, Dai Q., Free PMC Article | 09/29/2024 |
| Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway. | Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway.
Zhao Z, Chu W, Zheng Y, Wang C, Yang Y, Xu T, Yang X, Zhang W, Ding X, Li G, Zhang H, Zhou J, Ye J, Wu H, Song X, Wu Y., Free PMC Article | 08/30/2024 |
| Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis. | Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis.
Yi D, Zhang D, Zeng Z, Zhang S, Song B, He C, Li M, He J. | 10/10/2023 |
| Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit. | Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.
Elliff J, Biswas A, Roshan P, Kuppa S, Patterson A, Mattice J, Chinnaraj M, Burd R, Walker SE, Pozzi N, Antony E, Bothner B, Origanti S., Free PMC Article | 03/7/2023 |
| Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study. | Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study.
Scagliola A, Miluzio A, Mori G, Ricciardi S, Oliveto S, Manfrini N, Biffo S., Free PMC Article | 08/6/2022 |
| Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells. | Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells.
Keen AN, Payne LA, Mehta V, Rice A, Simpson LJ, Pang KL, Del Rio Hernandez A, Reader JS, Tzima E., Free PMC Article | 02/19/2022 |
| Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis. | Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis.
Cai SX, Chen WS, Zeng W, Cheng XF, Lin MB, Wang JS. | 01/8/2022 |
| Somatic genetic rescue of a germline ribosome assembly defect. | Somatic genetic rescue of a germline ribosome assembly defect.
Tan S, Kermasson L, Hilcenko C, Kargas V, Traynor D, Boukerrou AZ, Escudero-Urquijo N, Faille A, Bertrand A, Rossmann M, Goyenechea B, Jin L, Moreil J, Alibeu O, Beaupain B, Bôle-Feysot C, Fumagalli S, Kaltenbach S, Martignoles JA, Masson C, Nitschké P, Parisot M, Pouliet A, Radford-Weiss I, Tores F, de Villartay JP, Zarhrate M, Koh AL, Phua KB, Reversade B, Bond PJ, Bellanné-Chantelot C, Callebaut I, Delhommeau F, Donadieu J, Warren AJ, Revy P., Free PMC Article | 09/18/2021 |
| Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma. | Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
Scagliola A, Miluzio A, Ventura G, Oliveto S, Cordiglieri C, Manfrini N, Cirino D, Ricciardi S, Valenti L, Baselli G, D'Ambrosio R, Maggioni M, Brina D, Bresciani A, Biffo S., Free PMC Article | 09/4/2021 |
| eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway. | eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway.
Sun L, Liu S, Wang X, Zheng X, Chen Y, Shen H., Free PMC Article | 07/10/2021 |
| Heterozygous missense variant in EIF6 gene: A novel form of Shwachman-Diamond syndrome? | Heterozygous missense variant in EIF6 gene: A novel form of Shwachman-Diamond syndrome?
Koh AL, Bonnard C, Lim JY, Liew WK, Thoon KC, Thomas T, Ali NAB, Ng AYJ, Tohari S, Phua KB, Venkatesh B, Reversade B, Jamuar SS. | 06/12/2021 |
| Regulation of eukaryotic translation initiation factor 6 dynamics through multisite phosphorylation by GSK3. | Regulation of eukaryotic translation initiation factor 6 dynamics through multisite phosphorylation by GSK3.
Jungers CF, Elliff JM, Masson-Meyers DS, Phiel CJ, Origanti S., Free PMC Article | 02/2/2021 |
| Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits. | Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits.
Pesce E, Miluzio A, Turcano L, Minici C, Cirino D, Calamita P, Manfrini N, Oliveto S, Ricciardi S, Grifantini R, Degano M, Bresciani A, Biffo S., Free PMC Article | 01/16/2021 |
| High Eukaryotic translation initiation factor 6 expression is associated with gastric cancer. | Eukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer.
Golob-Schwarzl N, Wodlej C, Kleinegger F, Gogg-Kamerer M, Birkl-Toeglhofer AM, Petzold J, Aigelsreiter A, Thalhammer M, Park YN, Haybaeck J., Free PMC Article | 11/30/2019 |
| Data suggest an important contribution of eukaryotic translation initiation factor 6 (eIF6) to the development and progression of non-small cell lung cancer (NSCLC) and a potential for new treatment strategies against NSCLC. | Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression.
Gantenbein N, Bernhart E, Anders I, Golob-Schwarzl N, Krassnig S, Wodlej C, Brcic L, Lindenmann J, Fink-Neuboeck N, Gollowitsch F, Stacher-Priehse E, Asslaber M, Gogg-Kamerer M, Rolff J, Hoffmann J, Silvestri A, Regenbrecht C, Reinhard C, Pehserl AM, Pichler M, Sokolova O, Naumann M, Mitterer V, Pertschy B, Bergler H, Popper H, Sattler W, Haybaeck J. | 04/20/2019 |
| in human CD4(+) T cells, eIF6 levels rapidly increase upon T-cell receptor activation and drive the glycolytic switch and the acquisition of effector functions | High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4(+) T cells in both mice and humans.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Biffo S. | 07/14/2018 |
| Studies indicate that eukaryotic translation initiation factor 6 (eIF6) is a central regulator of metabolism independent from mTOR protein and myc proto-oncogene protein (Myc). | Translational control by mTOR-independent routes: how eIF6 organizes metabolism.
Miluzio A, Ricciardi S, Manfrini N, Alfieri R, Oliveto S, Brina D, Biffo S. | 07/22/2017 |
| Propose that eIF6 is necessary for malignant pleural mesothelioma growth. | Expression and activity of eIF6 trigger malignant pleural mesothelioma growth in vivo.
Miluzio A, Oliveto S, Pesce E, Mutti L, Murer B, Grosso S, Ricciardi S, Brina D, Biffo S., Free PMC Article | 09/10/2016 |
| EIF6 plays an important role in controlling cell motility and tumor metastasis. | EIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins.
Pinzaglia M, Montaldo C, Polinari D, Simone M, La Teana A, Tripodi M, Mancone C, Londei P, Benelli D., Free PMC Article | 01/23/2016 |
| eIF6 is a node regulator of ribosomal function and predict that prioritizing its pharmacological targeting will be of benefit in cancer and Shwachman-Bodian-Diamond syndrome | eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.
Brina D, Miluzio A, Ricciardi S, Biffo S. | 08/22/2015 |
| SBDS protein facilitates the release of eIF6, a factor that prevents ribosome joining. | Impaired ribosomal subunit association in Shwachman-Diamond syndrome.
Burwick N, Coats SA, Nakamura T, Shimamura A., Free PMC Article | 02/16/2013 |
| eIF6 is one of the downstream effectors of Notch-1 in the pathway that controls cell motility and invasiveness in tumor cell lines | The translation factor eIF6 is a Notch-dependent regulator of cell migration and invasion.
Benelli D, Cialfi S, Pinzaglia M, Talora C, Londei P., Free PMC Article | 08/4/2012 |
| The interactions between P311 and ITGB4BP may be very important in the process of tumor cell differentiation and metastasis. | Identification of ITGB4BP as a new interaction protein of P311.
Peng X, Yuan S, Tan J, Ma B, Bian X, Xu C, He W, Cao H, Huang Z, Cui Y, Gan C, Wang X, Zhou J, Hu J, Yang S, Luo G, Wu J. | 06/16/2012 |
| The benign prognosis of the Shwachman-Diamond syndrome patients with the int del (20)(q11.21q13.32) may be due to a gene/dosage effect for the EIF6 protein. | Deletion of chromosome 20 in bone marrow of patients with Shwachman-Diamond syndrome, loss of the EIF6 gene and benign prognosis.
Pressato B, Valli R, Marletta C, Mare L, Montalbano G, Lo Curto F, Pasquali F, Maserati E. | 06/16/2012 |
| Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6) and hnRNA splicing (SF3B2/SF3B4), showed that human T cells can enter the cell cycle without growing in size. | Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry.
Orr SJ, Boutz DR, Wang R, Chronis C, Lea NC, Thayaparan T, Hamilton E, Milewicz H, Blanc E, Mufti GJ, Marcotte EM, Thomas NS., Free PMC Article | 05/26/2012 |