| Serum interalpha-trypsin inhibitor heavy chain H4 may be an anti-inflammatory marker reflecting disease risk, activity and treatment outcome of ankylosing spondylitis. | Serum interα-trypsin inhibitor heavy chain H4 may be an anti-inflammatory marker reflecting disease risk, activity and treatment outcome of ankylosing spondylitis.
Sun Z, Zhang Y, Zhou H, Li J, Zhou Y, Wang L. | 02/5/2024 |
| Hyperglycosylated N-Linked Site 339 of gp120 Appears to Be Unique and May Contribute to CRF01_AE Transmission Among Men Who Have Sex with Men in China and Thailand. | Hyperglycosylated N-Linked Site 339 of gp120 Appears to Be Unique and May Contribute to CRF01_AE Transmission Among Men Who Have Sex with Men in China and Thailand.
Du J, Lin Y, Liang H, Li J, Wang F, Jiang C, Shao B. | 09/12/2023 |
| PGK1 modulates balance between pro- and anti-inflammatory cytokines by interacting with ITI-H4. | PGK1 modulates balance between pro- and anti-inflammatory cytokines by interacting with ITI-H4.
Park HB, Choi BC, Baek KH. | 04/7/2023 |
| Serum ITIH4 in coronary heart disease: a potential anti-inflammatory biomarker related to stenosis degree and risk of major adverse cardiovascular events. | Serum ITIH4 in coronary heart disease: a potential anti-inflammatory biomarker related to stenosis degree and risk of major adverse cardiovascular events.
Huo Y, Lai Y, Feng Q, Wang Q, Li J. | 03/27/2023 |
| Longitudinal change of serum inter-alpha-trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis. | Longitudinal change of serum inter-alpha-trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis.
Zhao X, Guo Y, Li L, Li Y., Free PMC Article | 03/9/2023 |
| Associations between KCNQ1 and ITIH4 gene polymorphisms and infant weight gain in early life. | Associations between KCNQ1 and ITIH4 gene polymorphisms and infant weight gain in early life.
Zhang Y, Mei H, Xu K, Li C, Chang R, Qi H, Zhang Y, Zhang J. | 06/11/2022 |
| ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection. | ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection.
Ma Y, Li R, Wang J, Jiang W, Yuan X, Cui J, Wang C. | 01/22/2022 |
| ITIH4 is a novel serum biomarker for early gastric cancer diagnosis. | ITIH4 is a novel serum biomarker for early gastric cancer diagnosis.
Sun Y, Jin J, Jing H, Lu Y, Zhu Q, Shu C, Zhang Q, Jing D. | 12/11/2021 |
| Citrullinated inter-alpha-trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration. | Citrullinated inter-alpha-trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration.
Osada A, Matsumoto I, Mikami N, Ohyama A, Kurata I, Kondo Y, Tsuboi H, Ishigami A, Sano Y, Arai T, Ise N, Sumida T., Free PMC Article | 10/2/2021 |
| sgp120 or ITIH4 is cleaved when the contact system is activated and this cleavage could be used as a biomarker in patients with hereditary angioedema with normal C1 inhibitor | sgp120 and the contact system in hereditary angioedema: A diagnostic tool in HAE with normal C1 inhibitor.
Larrauri B, Hester CG, Jiang H, Miletic VD, Malbran A, Bork K, Kaplan A, Frank M. | 04/18/2020 |
| ITIH4 SNPs rs3821831 and rs2239547 were studied in pregnant depressed Japanese women. Compared with the TT genotype of ITIH4 SNP rs2239547, the CC genotype was significantly related to a reduced risk of depressive symptoms during pregnancy. SNP rs3821831 was not related to these symptoms.The GCCT haplotype of rs2535629, rs736408, rs3821831, and rs2239547 was significantly positively associated with depressive symptoms. | ITIH3 and ITIH4 polymorphisms and depressive symptoms during pregnancy in Japan: the Kyushu Okinawa Maternal and Child Health Study.
Miyake Y, Tanaka K, Arakawa M. | 11/16/2019 |
| The ITI-H4 (N(688)) might be a crucial inflammatory factor which contributes to the pathogenesis of recurrent pregnancy loss (RPL). Moreover, it is expected that this study would give some insights into potential functional mechanisms underlying RPL. | Opposing roles of inter-α-trypsin inhibitor heavy chain 4 in recurrent pregnancy loss.
Li L, Choi BC, Ryoo JE, Song SJ, Pei CZ, Lee KY, Paek J, Baek KH., Free PMC Article | 03/16/2019 |
| Low ITIH4 expression is associated with Hepatocellular Carcinoma. | ITIH4: Effective Serum Marker, Early Warning and Diagnosis, Hepatocellular Carcinoma.
Li X, Li B, Li B, Guo T, Sun Z, Li X, Chen L, Chen W, Chen P, Mao Y, Zeng Y. | 10/27/2018 |
| this report has further supported for associations of genetic variants in the ITIH4 and CALN1 genes with schizophrenia and provided the first evidence that the variants regulate ITIH4 AND CALN1 expression in the dorsolateral prefrontal cortex | Schizophrenia risk variants in ITIH4 and CALN1 regulate gene expression in the dorsolateral prefrontal cortex.
Ohi K, Shimada T, Nitta Y, Kihara H, Okubo H, Uehara T, Kawasaki Y. | 01/14/2017 |
| confirmed the association of schizophrenia with ITIH3/4 in a Han Chinese population | Loci with genome-wide associations with schizophrenia in the Han Chinese population.
Li Z, Xiang Y, Chen J, Li Q, Shen J, Liu Y, Li W, Xing Q, Wang Q, Wang L, Feng G, He L, Zhao X, Shi Y. | 10/22/2016 |
| ITIH4 peptide isoform as a preterm birth biomarker and its associated SNP implications | Serological targeted analysis of an ITIH4 peptide isoform: a preterm birth biomarker and its associated SNP implications.
Tan Z, Hu Z, Cai EY, Alev C, Yang T, Li Z, Sung J, El-Sayed YY, Shaw GM, Stevenson DK, Butte AJ, Sheng G, Sylvester KG, Cohen HJ, Ling XB., Free PMC Article | 04/2/2016 |
| Serum ITIH4 may be a PM10-specific biomarker in COPD and may be related to inflammation. | Inter-alpha-trypsin inhibitor heavy chain 4: a novel biomarker for environmental exposure to particulate air pollution in patients with chronic obstructive pulmonary disease.
Lee KY, Feng PH, Ho SC, Chuang KJ, Chen TT, Su CL, Liu WT, Chuang HC., Free PMC Article | 02/6/2016 |
| Four novel body mass index-associated loci near the KCNQ1(rs2237892), ALDH2/MYL2 (rs671, rs12229654), ITIH4 (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations. | Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY, Dorajoo R, Li H, Tsai FJ, Yang X, He J, Wu Y, He M, Zhang Y, Liang J, Guo X, Sheu WH, Delahanty R, Guo X, Kubo M, Yamamoto K, Ohkubo T, Go MJ, Liu JJ, Gan W, Chen CC, Gao Y, Li S, Lee NR, Wu C, Zhou X, Song H, Yao J, Lee IT, Long J, Tsunoda T, Akiyama K, Takashima N, Cho YS, Ong RT, Lu L, Chen CH, Tan A, Rice TK, Adair LS, Gui L, Allison M, Lee WJ, Cai Q, Isomura M, Umemura S, Kim YJ, Seielstad M, Hixson J, Xiang YB, Isono M, Kim BJ, Sim X, Lu W, Nabika T, Lee J, Lim WY, Gao YT, Takayanagi R, Kang DH, Wong TY, Hsiung CA, Wu IC, Juang JM, Shi J, Choi BY, Aung T, Hu F, Kim MK, Lim WY, Wang TD, Shin MH, Lee J, Ji BT, Lee YH, Young TL, Shin DH, Chun BY, Cho MC, Han BG, Hwu CM, Assimes TL, Absher D, Yan X, Kim E, Kuo JZ, Kwon S, Taylor KD, Chen YD, Rotter JI, Qi L, Zhu D, Wu T, Mohlke KL, Gu D, Mo Z, Wu JY, Lin X, Miki T, Tai ES, Lee JY, Kato N, Shu XO, Tanaka T., Free PMC Article | 06/6/2015 |
| Worse survival among HCC patients with low ITIH4. | Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma.
Noh CK, Kim SS, Kim DK, Lee HY, Cho HJ, Yoon SY, Lee GH, Hyun SA, Kim YJ, Kim HJ, Hwang JA, Ahn SJ, Shin SJ, Lee KM, Yoo BM, Cho SW, Cheong JY. | 05/16/2015 |
| Isoform-specific ITIH4 glycosylation and utilization of O-glycosylation sites on ITIH4 differs between cell lines and serum. | Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain H4.
Chandler KB, Brnakova Z, Sanda M, Wang S, Stalnaker SH, Bridger R, Zhao P, Wells L, Edwards NJ, Goldman R., Free PMC Article | 02/28/2015 |
| A novel association between suicide attempt and the ITIH3/4-region in a combined group of patients with bipolar disorder, schizophrenia and related psychosis spectrum disorders. | Association analysis between suicidal behaviour and candidate genes of bipolar disorder and schizophrenia.
Finseth PI, Sønderby IE, Djurovic S, Agartz I, Malt UF, Melle I, Morken G, Andreassen OA, Vaaler AE, Tesli M. | 10/18/2014 |
| Expression of the 85 kDa ITIH4 was substantial in amyotrophic lateral sclerosis compared with controls or patients with muscular dystrophy, Alzheimer diseases, or Parkinson diseases | ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis.
Tanaka H, Shimazawa M, Takata M, Kaneko H, Tsuruma K, Ikeda T, Warita H, Aoki M, Yamada M, Takahashi H, Hozumi I, Minatsu H, Inuzuka T, Hara H. | 02/22/2014 |
| A truncated fragment of inter-alpha-trypsin inhibitor heavy chain 4 was the sole protein found to be significantly enhanced in the prostate cancer patients compared to the controls. | Urine of patients with early prostate cancer contains lower levels of light chain fragments of inter-alpha-trypsin inhibitor and saposin B but increased expression of an inter-alpha-trypsin inhibitor heavy chain 4 fragment.
Jayapalan JJ, Ng KL, Shuib AS, Razack AH, Hashim OH. | 10/26/2013 |
| Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools. | ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
Kim MS, Gu BH, Song S, Choi BC, Cha DH, Baek KH. | 10/1/2011 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
So HC, Fong PY, Chen RY, Hui TC, Ng MY, Cherny SS, Mak WW, Cheung EF, Chan RC, Chen EY, Li T, Sham PC. | 12/2/2009 |