| New insights of DsbA-L in the pathogenesis of metabolic diseases. | New insights of DsbA-L in the pathogenesis of metabolic diseases.
Li S, Wan J, Peng Z, Huang Q, He B. | 11/4/2024 |
| [Multifaceted Clinical Research on Obesity-related Disease Prevention Focusing on the DsbA-L Gene]. | [Multifaceted Clinical Research on Obesity-related Disease Prevention Focusing on the DsbA-L Gene].
Oniki K. | 11/12/2022 |
| T cell metabolism in obesity and beyond: comments on 'DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-gamma production'. | T cell metabolism in obesity and beyond: comments on 'DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production'.
Zhou H, Liu F., Free PMC Article | 02/19/2022 |
| Silencing of DsbA-L gene impairs the PPARgamma agonist function of improving insulin resistance in a high-glucose cell model. | Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model.
Zhou X, Li JQ, Wei LJ, He MZ, Jia J, Zhang JY, Wang SS, Feng L., Free PMC Article | 11/22/2021 |
| Plasma mtDNA copy numbers are associated with GSTK1 expression and inflammation in type 2 diabetes. | Plasma mtDNA copy numbers are associated with GSTK1 expression and inflammation in type 2 diabetes.
Deng X, Yang G, Zheng X, Yang Y, Qin H, Liu ZX, Deng H, Liu SM. | 10/30/2021 |
| The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties. | The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties.
Oniki K, Nohara H, Nakashima R, Obata Y, Muto N, Sakamoto Y, Ueno-Shuto K, Imafuku T, Ishima Y, Watanabe H, Maruyama T, Otake K, Ogata Y, Suico MA, Kai H, Shuto T, Saruwatari J., Free PMC Article | 12/5/2020 |
| DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice. | DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice.
Li X, Pan J, Li H, Li G, Liu X, Liu B, He Z, Peng Z, Zhang H, Li Y, Xiang X, Chai X, Yuan Y, Zheng P, Liu F, Zhang D., Free PMC Article | 10/10/2020 |
| DsbA-L modifies mtROS/JNK/MFF-related mitochondrial fission, linking alterations in mitochondrial dynamics during tubular injury in the pathogenesis of diabetic kidney disease. | DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.
Gao P, Yang M, Chen X, Xiong S, Liu J, Sun L. | 07/25/2020 |
| DsbA-L plays a critical protective role in renal ectopic fat deposition and lipid-related kidney injury in mice with diabetic nephropathy (DN) and patients with DN. The mechanisms might involve the inhibition of cholesterol synthesis through the inactivation of HMGCR and the promotion of lipolysis through the activation of ATGL and the subsequent reduction of lipid droplets accumulation in the kidney. | Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy.
Chen X, Han Y, Gao P, Yang M, Xiao L, Xiong X, Zhao H, Tang C, Chen G, Zhu X, Yuan S, Liu F, Dong LQ, Liu F, Kanwar YS, Sun L. | 02/15/2020 |
| The population prediction model of BMI indicated that the DsbA-L T/T genotype was significantly associated with a high BMI. The BMI-based NAFLD prediction model showed that the DsbA-L T/T genotype did not have any direct impact on the risk of NAFLD, whereas the structural equation model suggested that this genotype might be indirectly or partially associated with NAFLD risk through a high BMI and low adiponectin. | Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond-Forming Oxidoreductase A-Like Protein (DsbA-L) Polymorphism on the Weight Status.
Oniki K, Watanabe T, Kudo M, Izuka T, Ono T, Matsuda K, Sakamoto Y, Nagaoka K, Imafuku T, Ishima Y, Watanabe H, Maruyama T, Otake K, Ogata Y, Saruwatari J., Free PMC Article | 09/28/2019 |
| It is a key molecule in multimerization and activation of adiponectin. | [A Multifaceted Approach regarding the Association of the DsbA-L Gene with the Risk of Obesity-related Diseases Based on Clinical Pharmacogenetics].
Oniki K, Saruwatari J. | 04/27/2019 |
| No convincing evidence that the GST genotypes studied are related to asthma outcomes. | Variants in genes coding for glutathione S-transferases and asthma outcomes in children.
Turner S, Francis B, Wani N, Vijverberg S, Pino-Yanes M, Mukhopadhyay S, Tavendale R, Palmer C, Burchard EG, Merid SK, Melén E, Maitland-van der Zee AH, The Pharmacogenomics In Childhood Asthma Consortium OBO., Free PMC Article | 03/9/2019 |
| Several biological properties of the GST-hNdCTR1 fusion protein were assessed. It was demonstrated that in cells, the protein was prone to oligomerization, formed inclusion bodies and displayed no toxicity. Treatment of E. coli cells with copper and silver ions reduced cell viability in a dose- and time-dependent manner | The Extracellular Domain of Human High Affinity Copper Transporter (hNdCTR1), Synthesized by E. coli Cells, Chelates Silver and Copper Ions In Vivo.
Sankova TP, Orlov IA, Saveliev AN, Kirilenko DA, Babich PS, Brunkov PN, Puchkova LV., Free PMC Article | 07/21/2018 |
| we confirmed several existing chemoinformatic filters and more importantly extended them as well as added novel filters that specify compounds with anti-GST/GSH activity. Selected compounds were also tested using different antibody-based GST detection technologies and exhibited no interference clearly demonstrating specificity toward their GST/GSH interaction. | Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase-Glutathione Interaction.
Brenke JK, Salmina ES, Ringelstetter L, Dornauer S, Kuzikov M, Rothenaigner I, Schorpp K, Giehler F, Gopalakrishnan J, Kieser A, Gul S, Tetko IV, Hadian K. | 01/20/2018 |
| Our findings indicate that the medical staff exposed to low IR levels were under risk of significant oxidative stress that was enhanced by their glutathione S-transferase (GST) polymorphisms. | Oxidative stress and glutathione S-transferase genetic polymorphisms in medical staff professionally exposed to ionizing radiation.
Doukali H, Ben Salah G, Hamdaoui L, Hajjaji M, Tabebi M, Ammar-Keskes L, Masmoudi ME, Kamoun H. | 08/26/2017 |
| GSTK1 T/T genotype may be a novel risk factor for the prediction of overweight status in SCZ male patients. | Glutathione S-transferase K1 genotype and overweight status in schizophrenia patients: A pilot study.
Oniki K, Kamihashi R, Tomita T, Ishioka M, Yoshimori Y, Osaki N, Tsuchimine S, Sugawara N, Kajiwara A, Morita K, Miyata K, Otake K, Nakagawa K, Ogata Y, Saruwatari J, Yasui-Furukori N. | 03/4/2017 |
| High glutathione-S-transferase is associated with type 2 diabetes mellitus. | Association of glutathione-S-transferase with patients of type 2 diabetes mellitus with and without nephropathy.
Sharma M, Gupta S, Singh K, Mehndiratta M, Gautam A, Kalra OP, Shukla R, Gambhir JK. | 03/4/2017 |
| DsbA-L is localized in both the mitochondria and the endoplasmic reticulum (ER) in adipocytes; its ER localization plays a critical role in suppressing ER stress and promoting adiponectin biosynthesis and secretion. | Endoplasmic reticulum (ER) localization is critical for DsbA-L protein to suppress ER stress and adiponectin down-regulation in adipocytes.
Liu M, Chen H, Wei L, Hu D, Dong K, Jia W, Dong LQ, Liu F., Free PMC Article | 06/20/2015 |
| we have optimized the GST-Nck1-SH2 pull-down procedure to obtain tyrosine-phosphorylated proteins in tumor tissues | Detection of tyrosine‑phosphorylated proteins in hepatocellular carcinoma tissues using a combination of GST‑Nck1‑SH2 pull‑down and two‑dimensional electrophoresis.
Qiu F, Huang D, Xiao H, Qiu F, Lu L, Nie J. | 07/26/2014 |
| drug resistance in three strains of tumor cells is associated with significant increase in hGSTP1 and hGSTA4 gene expression, whereas increased hGSTK1 gene expression was detected only in resistant erythroleukemia and mammary adenocarcinoma cells. | Expression of genes of glutathione transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in tumor cells during the formation of drug resistance to cisplatin.
Kalinina EV, Berozov TT, Shtil AA, Chernov NN, Glasunova VA, Novichkova MD, Nurmuradov NK. | 05/4/2013 |
| This study does not give evidence of interaction between the GST polymorphisms and smoking may although this study provided sufficient statistical power to detect modest interaction. | GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population.
Kiyohara C, Miyake Y, Koyanagi M, Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Fukuoka Kinki Parkinson's Disease Study Group. | 11/13/2010 |
| SNP-1308G/T (rs1917760) genotypes of DsbA-L gene might participate in insulin secretion and body fat distribution. It is possible that polymorphisms of DsbA-L gene associated with metabolic diseases[DsbA-L] | Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population.
Gao F, Fang Q, Zhang R, Lu J, Lu H, Wang C, Ma X, Xu J, Jia W, Xiang K, Gao F, Fang Q, Zhang R, Lu J, Lu H, Wang C, Ma X, Xu J, Jia W, Xiang K. | 06/8/2010 |
| The objective of this study was to investigate the molecular mechanisms underlying Group B Streptococcus-human umbilical vein endothelial cells interaction, focusing specifically on the responsiveness of host protein tyrosine kinase (PTK). | Group B Streptococcus induces tyrosine phosphorylation of annexin V and glutathione S-transferase in human umbilical vein endothelial cells.
Santos GS, Loureiro y Penha CV, Mattos-Guaraldi AL, Attias M, Lopes-Bezerra LM, Silva-Filho FC, Nagao PE. | 01/21/2010 |
| Our results suggest that genetic polymorphisms of xenobiotic-metabolizing enzymes could play an important role in infertility. | Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility.
Aydos SE, Taspinar M, Sunguroglu A, Aydos K. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesPolymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population.
Gao F, Fang Q, Zhang R, Lu J, Lu H, Wang C, Ma X, Xu J, Jia W, Xiang K, Gao F, Fang Q, Zhang R, Lu J, Lu H, Wang C, Ma X, Xu J, Jia W, Xiang K. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ. | 11/19/2008 |