| RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4. | RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4.
Zhang W, Xu Q, Shi C, Chen X, Shen C, Zhang Y, Zheng B, Zhu H. | 10/30/2024 |
| Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1. | Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1.
Yang Y, Li J, Wei C, Wang L, Gao Z, Shen K, Li Y, Ren M, Zhu Y, Ding Y, Wei C, Zhang T, Zheng S, Lu N, Gu J., Free PMC Article | 03/7/2024 |
| A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1. | A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
Hirano T, Wright D, Suzuki A, Saga Y. | 07/2/2022 |
| High DND1 Level Indicates a Poor Prognostic Factor in Prostate Cancer. | High DND1 Level Indicates a Poor Prognostic Factor in Prostate Cancer.
Xu G, Yang X, Li C, Wang F, Cui J, Li B, Xiao H, Tang K, Cui Z., Free PMC Article | 02/5/2022 |
| Human DND1-RRM2 forms a non-canonical domain swapped dimer. | Human DND1-RRM2 forms a non-canonical domain swapped dimer.
Kumari P, Bhavesh NS., Free PMC Article | 12/25/2021 |
| MicroRNA-24 inhibits the proliferation, migration and invasion and enhances chemosensitivity of human gastric cancer by targeting DND1. | MicroRNA-24 inhibits the proliferation, migration and invasion and enhances chemosensitivity of human gastric cancer by targeting DND1.
Jiang W, Meng K, Sheng G, Yang T. | 02/13/2021 |
| Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention. | RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells.
Xu W, Gong F, Zhang T, Chi B, Wang J. | 04/14/2018 |
| Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR. | RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site.
Cheng F, Pan Y, Lu YM, Zhu L, Chen S., Free PMC Article | 02/18/2017 |
| RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation | The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation.
Wampfler J, Federzoni EA, Torbett BE, Fey MF, Tschan MP. | 06/28/2016 |
| APOBEC3G inhibits DND1 function to regulate microRNA activity. | APOBEC3 inhibits DEAD-END function to regulate microRNA activity.
Ali S, Karki N, Bhattacharya C, Zhu R, MacDuff DA, Stenglein MD, Schumacher AJ, Demorest ZL, Harris RS, Matin A, Aggarwal S., Free PMC Article | 10/19/2013 |
| The increased sensitivity of transformed keratinocytes to miR-21's effects occurs in part through downregulation of the RNA-binding protein DND1 during the transformation process. | The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1.
Bhandari A, Gordon W, Dizon D, Hopkin AS, Gordon E, Yu Z, Andersen B., Free PMC Article | 06/22/2013 |
| Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells. | Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells.
Zhu R, Iacovino M, Mahen E, Kyba M, Matin A., Free PMC Article | 02/25/2012 |
| We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility | Screening for germline DND1 mutations in testicular cancer patients.
Sijmons RH, Vos YJ, Herkert JC, Bos KK, Lutke Holzik MF, Hoekstra-Weebers JE, Hofstra RM, Hoekstra HJ, Sijmons RH, Vos YJ, Herkert JC, Bos KK, Lutke Holzik MF, Hoekstra-Weebers JE, Hofstra RM, Hoekstra HJ., Free PMC Articles: PMC2921500, PMC2921500 | 12/4/2010 |
| Cloning of zebrafish dnd1 and identification of human DND1 by database analysis. | dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival.
Weidinger G, Stebler J, Slanchev K, Dumstrei K, Wise C, Lovell-Badge R, Thisse C, Thisse B, Raz E. | 12/3/2010 |
| Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression. | RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.
Kedde M, Strasser MJ, Boldajipour B, Oude Vrielink JA, Slanchev K, le Sage C, Nagel R, Voorhoeve PM, van Duijse J, Ørom UA, Lund AH, Perrakis A, Raz E, Agami R. | 12/2/2010 |
| MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. | MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma.
Liu X, Wang A, Heidbreder CE, Jiang L, Yu J, Kolokythas A, Huang L, Dai Y, Zhou X., Free PMC Article | 10/23/2010 |
| The variant, p. Glu86Ala, found in only one case of testiciular germ cell tumor, is within a known functional domain of DND1 and is highly conserved through evolution; mutations in DND1 make, at most, a very small contribution to TGCT susceptibility | Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.
Linger R, Dudakia D, Huddart R, Tucker K, Friedlander M, Phillips KA, Hogg D, Jewett MA, Lohynska R, Daugaard G, Richard S, Chompret A, Stoppa-Lyonnet D, Bonaïti-Pellié C, Heidenreich A, Albers P, Olah E, Geczi L, Bodrogi I, Daly PA, Guilford P, Fosså SD, Heimdal K, Tjulandin SA, Liubchenko L, Stoll H, Weber W, Einhorn L, McMaster M, Korde L, Greene MH, Nathanson KL, Cortessis V, Easton DF, Bishop DT, Stratton MR, Rapley EA, Linger R, Dudakia D, Huddart R, Tucker K, Friedlander M, Phillips KA, Hogg D, Jewett MA, Lohynska R, Daugaard G, Richard S, Chompret A, Stoppa-Lyonnet D, Bonaïti-Pellié C, Heidenreich A, Albers P, Olah E, Geczi L, Bodrogi I, Daly PA, Guilford P, Fosså SD, Heimdal K, Tjulandin SA, Liubchenko L, Stoll H, Weber W, Einhorn L, McMaster M, Korde L, Greene MH, Nathanson KL, Cortessis V, Easton DF, Bishop DT, Stratton MR, Rapley EA., Free PMC Articles: PMC3109865, PMC3109865 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesScreening for germline DND1 mutations in testicular cancer patients.
Sijmons RH, Vos YJ, Herkert JC, Bos KK, Lutke Holzik MF, Hoekstra-Weebers JE, Hofstra RM, Hoekstra HJ, Sijmons RH, Vos YJ, Herkert JC, Bos KK, Lutke Holzik MF, Hoekstra-Weebers JE, Hofstra RM, Hoekstra HJ. Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.
Linger R, Dudakia D, Huddart R, Tucker K, Friedlander M, Phillips KA, Hogg D, Jewett MA, Lohynska R, Daugaard G, Richard S, Chompret A, Stoppa-Lyonnet D, Bonaïti-Pellié C, Heidenreich A, Albers P, Olah E, Geczi L, Bodrogi I, Daly PA, Guilford P, Fosså SD, Heimdal K, Tjulandin SA, Liubchenko L, Stoll H, Weber W, Einhorn L, McMaster M, Korde L, Greene MH, Nathanson KL, Cortessis V, Easton DF, Bishop DT, Stratton MR, Rapley EA, Linger R, Dudakia D, Huddart R, Tucker K, Friedlander M, Phillips KA, Hogg D, Jewett MA, Lohynska R, Daugaard G, Richard S, Chompret A, Stoppa-Lyonnet D, Bonaïti-Pellié C, Heidenreich A, Albers P, Olah E, Geczi L, Bodrogi I, Daly PA, Guilford P, Fosså SD, Heimdal K, Tjulandin SA, Liubchenko L, Stoll H, Weber W, Einhorn L, McMaster M, Korde L, Greene MH, Nathanson KL, Cortessis V, Easton DF, Bishop DT, Stratton MR, Rapley EA. | 03/13/2008 |