| KCND2 variants associated with global developmental delay differentially impair Kv4.2 channel gating. | KCND2 variants associated with global developmental delay differentially impair Kv4.2 channel gating.
Zhang Y, Tachtsidis G, Schob C, Koko M, Hedrich UBS, Lerche H, Lemke JR, van Haeringen A, Ruivenkamp C, Prescott T, Tveten K, Gerstner T, Pruniski B, DiTroia S, VanNoy GE, Rehm HL, McLaughlin H, Bolz HJ, Zechner U, Bryant E, McDonough T, Kindler S, Bähring R., Free PMC Article | 04/2/2022 |
| Structural basis of gating modulation of Kv4 channel complexes. | Structural basis of gating modulation of Kv4 channel complexes.
Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O., Free PMC Article | 01/15/2022 |
| Potassium voltage-gated channel subfamily D member 2 induces an aggressive phenotype in lung adenocarcinoma. | Potassium voltage-gated channel subfamily D member 2 induces an aggressive phenotype in lung adenocarcinoma.
Lu X, Li K, Yang J. | 02/13/2021 |
| Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis neuronal 3 protein CLN3. | Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis neuronal 3 protein CLN3.
Seifert C, Storch S, Bähring R., Free PMC Article | 01/23/2021 |
| The atrial-specific phenotype suggests that targeting Kv4.2 might be effective in the treatment of nocturnal paroxysmal atrial fibrillation, avoiding adverse ventricular effects. | Nocturnal Atrial Fibrillation Caused by Mutation in KCND2, Encoding Pore-Forming (α) Subunit of the Cardiac Kv4.2 Potassium Channel.
Drabkin M, Zilberberg N, Menahem S, Mulla W, Halperin D, Yogev Y, Wormser O, Perez Y, Kadir R, Etzion Y, Katz A, Birk OS. | 09/21/2019 |
| KCND2 upregulation is a valuable prognostic biomarker in gastric cancer patients, in terms of overall survival and recurrence-free survival. | KCND2 upregulation might be an independent indicator of poor survival in gastric cancer.
Wei H, Li Y, Du Y, Ma J. | 05/25/2019 |
| A mutation, V404M, in the Kv4.2 channel subunit is associated with infant-onset epilepsy and autism. V404M enhances inactivation of channels that have not opened but dramatically impairs inactivation after opening. Authors show that increased side-chain volume is largely responsible for these seemingly paradoxical effects. | Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening.
Lin MA, Cannon SC, Papazian DM., Free PMC Article | 08/25/2018 |
| Our results do not support the notion that accessory KChIP2 binding is a prerequisite for dendritic trafficking and functional surface expression of Kv4.2 channels, however, accessory KChIP2 binding may play a potential role in Kv4.2 modulation during intrinsic plasticity processes. | Somatodendritic surface expression of epitope-tagged and KChIP binding-deficient Kv4.2 channels in hippocampal neurons.
Prechtel H, Hartmann S, Minge D, Bähring R., Free PMC Article | 03/17/2018 |
| Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons. | Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.
Yao JJ, Zhao QR, Liu DD, Chow CW, Mei YA., Free PMC Article | 05/7/2017 |
| closed-state inactivation in Kv4.2 channels is a multistep process | Intra- and Intersubunit Dynamic Binding in Kv4.2 Channel Closed-State Inactivation.
Wollberg J, Bähring R., Free PMC Article | 10/8/2016 |
| The study provides the first piece of evidence for the role of H2S in regulating Ito potassium channels and also the specific motif in an ion channel labile for H2S regulation. | Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the Ito Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction.
Ma SF, Luo Y, Ding YJ, Chen Y, Pu SX, Wu HJ, Wang ZF, Tao BB, Wang WW, Zhu YC., Free PMC Article | 03/19/2016 |
| The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit, with a preference for 4:2 stoichiometry | Kv4.2 and accessory dipeptidyl peptidase-like protein 10 (DPP10) subunit preferentially form a 4:2 (Kv4.2:DPP10) channel complex.
Kitazawa M, Kubo Y, Nakajo K., Free PMC Article | 12/5/2015 |
| The findings of this study suggest that variations in KCND2 genes are associated with both mild and severe persistent breast pain after breast cancer surgery. | Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery.
Langford DJ, Paul SM, West CM, Dunn LB, Levine JD, Kober KM, Dodd MJ, Miaskowski C, Aouizerat BE. | 11/7/2015 |
| A rare genetic mutation of the KCND2 gene, p.D612N, was identified in a single patient. Co-expression of mutant and wild-type KCND2 with KChIP2 demonstrated a gain-of-function phenotype. | Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death.
Perrin MJ, Adler A, Green S, Al-Zoughool F, Doroshenko P, Orr N, Uppal S, Healey JS, Birnie D, Sanatani S, Gardner M, Champagne J, Simpson C, Ahmad K, van den Berg MP, Chauhan V, Backx PH, van Tintelen JP, Krahn AD, Gollob MH. | 07/25/2015 |
| S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation. | S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation.
Jerng HH, Pfaffinger PJ., Free PMC Article | 05/30/2015 |
| study identified a de novo variant p.Val404Met in KCND2 in a family with identical twins affected with autism and severe seizures; findings suggest KCND2 is the causal gene for epilepsy in this family and has a role in the etiology of autism | Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation.
Lee H, Lin MC, Kornblum HI, Papazian DM, Nelson SF., Free PMC Article | 02/28/2015 |
| Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4. | The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level.
Kitazawa M, Kubo Y, Nakajo K., Free PMC Article | 10/11/2014 |
| reflected in the immunoblotting data KV4.2 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy. | Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.
Sukigara S, Dai H, Nabatame S, Otsuki T, Hanai S, Honda R, Saito T, Nakagawa E, Kaido T, Sato N, Kaneko Y, Takahashi A, Sugai K, Saito Y, Sasaki M, Goto Y, Koizumi S, Itoh M. | 09/6/2014 |
| KCND2 is expressed in human skin, but has not been associated with aging. | Identification of genes promoting skin youthfulness by genome-wide association study.
Chang ALS, Atzmon G, Bergman A, Brugmann S, Atwood SX, Chang HY, Barzilai N., Free PMC Article | 04/12/2014 |
| WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude | The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D., Free PMC Article | 02/22/2014 |
| Our results support the hypothesis that KChIPs enhances Kv4.2 functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression. | Functional stoichiometry underlying KChIP regulation of Kv4.2 functional expression.
Kunjilwar K, Qian Y, Pfaffinger PJ., Free PMC Article | 10/26/2013 |
| Autoantibodies from patients with encephalitis are specific for DPPX (a subunit of Kv4.2) without reacting to Kv4.2. | Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels.
Boronat A, Gelfand JM, Gresa-Arribas N, Jeong HY, Walsh M, Roberts K, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R, Graus F, Rudy B, Dalmau J., Free PMC Article | 03/30/2013 |
| Seizures in Kv4.2 transgenic mice rapidly redistribute K+ channel subunit Kv4.2 to the neuronal surface, implicating a molecular substrate for the increased K+ current. | Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels.
Smith SE, Xu L, Kasten MR, Anderson MP., Free PMC Article | 03/10/2012 |
| KChIP2 differentially regulates total and cell surface Kv4.2 protein expression and Kv4 current densities. | Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes.
Foeger NC, Marionneau C, Nerbonne JM., Free PMC Article | 11/27/2010 |
| MiRP3 modulates Kv4.2 current activation, inactivation and recovery from inactivation. MiRP3 shifts the half-maximal voltage for activation and slows time to peak ~ 100%. | The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.
Levy DI, Cepaitis E, Wanderling S, Toth PT, Archer SL, Goldstein SA., Free PMC Article | 11/6/2010 |