| Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence. | Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence.
Rinné S, Schick F, Vowinkel K, Schütte S, Krasel C, Kauferstein S, Schäfer MK, Kiper AK, Müller T, Decher N., Free PMC Article | 09/4/2024 |
| Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal Cascade on Hypertension. | Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal Cascade on Hypertension.
Huang D, Shang W, Xu M, Wan Q, Zhang J, Tang X, Shen Y, Wang Y, Yu Y. | 08/16/2024 |
| Activation of neurokinin-III receptors modulates human atrial TASK-1 currents. | Activation of neurokinin-III receptors modulates human atrial TASK-1 currents.
Wiedmann F, Paasche A, Nietfeld J, Kraft M, Meyer AL, Warnecke G, Karck M, Frey N, Schmidt C. | 12/6/2023 |
| Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells. | Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells.
Yeo Y, Jeong H, Kim M, Choi Y, Kim KL, Suh W., Free PMC Article | 12/3/2022 |
| Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea. | Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea.
Sörmann J, Schewe M, Proks P, Jouen-Tachoire T, Rao S, Riel EB, Agre KE, Begtrup A, Dean J, Descartes M, Fischer J, Gardham A, Lahner C, Mark PR, Muppidi S, Pichurin PN, Porrmann J, Schallner J, Smith K, Straub V, Vasudevan P, Willaert R, Carpenter EP, Rödström KEJ, Hahn MG, Müller T, Baukrowitz T, Hurles ME, Wright CF, Tucker SJ., Free PMC Article | 10/15/2022 |
| MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation. | MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation.
Wiedmann F, Kraft M, Kallenberger S, Büscher A, Paasche A, Blochberger PL, Seeger T, Jávorszky N, Warnecke G, Arif R, Kremer J, Karck M, Frey N, Schmidt C., Free PMC Article | 04/16/2022 |
| Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors. | Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors.
Förch A, Wallner S, Zeman F, Ettl T, Brochhausen C, Schreml S., Free PMC Article | 02/26/2022 |
| TASK-1 regulates mitochondrial function under hypoxia. | TASK-1 regulates mitochondrial function under hypoxia.
Yu Y, He H, Kang C, Hu K. | 01/29/2022 |
| Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH. | Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.
Enyeart JJ, Enyeart JA., Free PMC Article | 09/11/2021 |
| KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models. | KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.
West JD, Austin ED, Rizzi EM, Yan L, Tanjore H, Crabtree AL, Moore CS, Muthian G, Carrier EJ, Jacobson DA, Hamid R, Kendall PL, Majka S, Rathinasabapathy A., Free PMC Article | 08/21/2021 |
| Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels. | Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels.
Cunningham KP, MacIntyre DE, Mathie A, Veale EL., Free PMC Article | 06/26/2021 |
| Vitamin D deficiency downregulates TASK-1 channels and induces pulmonary vascular dysfunction. | Vitamin D deficiency downregulates TASK-1 channels and induces pulmonary vascular dysfunction.
Callejo M, Mondejar-Parreño G, Morales-Cano D, Barreira B, Esquivel-Ruiz S, Olivencia MA, Manaud G, Perros F, Duarte J, Moreno L, Cogolludo A, Perez-Vizcaíno F. | 12/5/2020 |
| A lower X-gate in TASK channels traps inhibitors within the vestibule. | A lower X-gate in TASK channels traps inhibitors within the vestibule.
Rödström KEJ, Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Müller T, Decher N, Carpenter EP. | 09/26/2020 |
| Mutations associated with pulmonary hypertension substantially reduce current through TASK-1 channel. | Characterization and regulation of wild-type and mutant TASK-1 two pore domain potassium channels indicated in pulmonary arterial hypertension.
Cunningham KP, Holden RG, Escribano-Subias PM, Cogolludo A, Veale EL, Mathie A., Free PMC Article | 05/16/2020 |
| The GG genotype of rs1275988 and GG genotype of rs2586886 in the TASK-1 (KCNK3) gene are potential risk factors for obstructive sleep apnea (OSA) in obese patients. | Genetic variants of rs1275988 and rs2586886 in TWIK-related acid-sensitive K+ channel-1 gene may be potential risk factors for obese patients with obstructive sleep apnea.
Shi T, Yao XG, Li M, Heizhati M, Li XF, Wen L, He YY, Yao L, Wang YC, Hong J, Li NF., Free PMC Article | 05/9/2020 |
| Both the GG genotypes of rs1275988 and rs2586886 in the TASK-1 gene may be potential risk factors in severe obstructive sleep apnea patients with blood potassium <3.95 mmol/L. | [GG Genotype at rs1275988 and rs2586886 Loci of TWIK-related Acid-sensitive K (+) Channel-1 Gene is A Potential Risk Factor for Severe Obstructive Sleep Apnea].
Zhang L, Shi T, Yao XG, Li M, Mulalibike H, Li XF, Wen L, Yao L, He YY, Wang YC, Hong J, Li NF. | 04/4/2020 |
| Here, the authors identified a novel binding site and allosteric inhibition mechanism, disrupting the recently proposed K(+)-flux gating mechanism of two-pore-domain potassium channels, which results in an unusual voltage-dependent block of leak channels belonging to the TASK subfamily. | The molecular basis for an allosteric inhibition of K(+)-flux gating in K(2P) channels.
Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, Gonzalez W, Decher N., Free PMC Article | 03/28/2020 |
| Loss of KCNK3 function and expression is a hallmark of the RV hypertrophy/dysfunction associated with pulmonary hypertension. | Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension.
Lambert M, Boet A, Rucker-Martin C, Mendes-Ferreira P, Capuano V, Hatem S, Adão R, Brás-Silva C, Hautefort A, Michel JB, Dorfmuller P, Fadel E, Kotsimbos T, Price L, Jourdon P, Montani D, Humbert M, Perros F, Antigny F. | 08/31/2019 |
| The results of this study concluded that functional TASK1 channels participate in the modulation of differentiating oligodendroglial cells. | The K(2P) -channel TASK1 affects Oligodendroglial differentiation but not myelin restoration.
Albrecht S, Korr S, Nowack L, Narayanan V, Starost L, Stortz F, Araúzo-Bravo MJ, Meuth SG, Kuhlmann T, Hundehege P. | 08/3/2019 |
| Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site. | Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site.
Wiedmann F, Kiper AK, Bedoya M, Ratte A, Rinné S, Kraft M, Waibel M, Anad P, Wenzel W, González W, Katus HA, Decher N, Schmidt C. | 05/4/2019 |
| The results of the present study suggested that miR138 promoted proliferation and suppressed mitochondrial depolarization of human pulmonary artery smooth muscle cells by targeting TASK1. | MicroRNA‑138 promotes proliferation and suppresses mitochondrial depolarization in human pulmonary artery smooth muscle cells through targeting TASK‑1.
Liu JJ, Zhang H, Xing F, Tang B, Wu SL, Xuan L, Kang PF, Xu Q, Wang HJ, Zhang NR, Wang XJ., Free PMC Article | 08/25/2018 |
| Screening for mutations in the human TASK-1 gene in 155 cases of sudden infant death syndrome (SIDS) was inconclusive. Results are suggestive for an increased hypoxia-sensitivity of neonatal TASK-1(-/-) mice, however, without causing an increase in neonatal lethality. In adult female TASK-1(-/-) mice respiration was unaffected, whereas adult male TASK-1(-/-) mice showed a modified breathing pattern. | Sex-dependent differences in the in vivo respiratory phenotype of the TASK-1 potassium channel knockout mouse.
Jungbauer S, Buehler PK, Neubauer J, Haas C, Heitzmann D, Tegtmeier I, Sterner C, Barhanin J, Georgieff M, Warth R, Thomas J. | 07/28/2018 |
| Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. Furthermore, mutations in KCNK3 have been identified as a rare cause of both familial and idiopathic pulmonary arterial hypertension. [review] | TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications.
Olschewski A, Veale EL, Nagy BM, Nagaraj C, Kwapiszewska G, Antigny F, Lambert M, Humbert M, Czirják G, Enyedi P, Mathie A. | 07/21/2018 |
| Sequencing of BMPR2, CAV1, and KCNK3 coding regions did not identify any pathogenic variants in these genes in infants with pulmonary hypoplasia and pulmonary hypertension. | Mutations in BMPR2 are not present in patients with pulmonary hypertension associated with congenital diaphragmatic hernia.
Chiu JS, Ma L, Wynn J, Krishnan U, Rosenzweig EB, Aspelund G, Arkovitz M, Warner BW, Lim FY, Mychaliska GB, Azarow K, Cusick RA, Chung DH, Chung WK. | 05/26/2018 |
| Heterozygous KCNK3 mutations in pulmonary arterial hypertension lead to variable loss of channel function via distinct mechanisms. | The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery.
Bohnen MS, Roman-Campos D, Terrenoire C, Jnani J, Sampson KJ, Chung WK, Kass RS., Free PMC Article | 05/26/2018 |