| Cholesterol 25-Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4. | Cholesterol 25-Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4.
Zhang L, Fang Z, Zhu Q, Yang S, Fu J, Sun Z, Lu G, Wei C, Zhang Z, Lee K, Zhong Y, Liu R, He JC., Free PMC Article | 09/16/2024 |
| The ins and outs of the Arf4-based ciliary membrane-targeting complex. | The ins and outs of the Arf4-based ciliary membrane-targeting complex.
Deretic D, Lorentzen E, Fresquez T., Free PMC Article | 07/26/2024 |
| Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease. | Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease.
Zhang Q, Wu L, Bai B, Li D, Xiao P, Li Q, Zhang Z, Wang H, Li L, Jiang Q., Free PMC Article | 03/19/2022 |
| microRNA196a3p inhibits cell proliferation and promotes cell apoptosis by targeting ADP ribosylation factor 4 in diffuse large Bcell lymphoma. | microRNA‑196a‑3p inhibits cell proliferation and promotes cell apoptosis by targeting ADP ribosylation factor 4 in diffuse large B‑cell lymphoma.
Fu J, Lou X, Wan S, Zhao X, Chen Z, Zhu M, Guo L, Wu D, Wang S. | 11/22/2021 |
| Class II Arfs require a brefeldin-A-sensitive factor for Golgi association. | Class II Arfs require a brefeldin-A-sensitive factor for Golgi association.
Dejgaard SY, Presley JF. | 02/27/2021 |
| Study identified two novel sodium iodide symporter (NIS) interactors, valosin-containing protein (VCP) and ADP-ribosylation factor 4 (ARF4), with critical roles in modulating NIS function as well as correlating markedly with clinical outcome in papillary thyroid cancer. ARF4 enhanced NIS vesicular trafficking from the Golgi to the plasma membrane, whereas VCP governed NIS proteolysis. | Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake.
Fletcher A, Read ML, Thornton CEM, Larner DP, Poole VL, Brookes K, Nieto HR, Alshahrani M, Thompson RJ, Lavery GG, Landa I, Fagin JA, Campbell MJ, Boelaert K, Turnell AS, Smith VE, McCabe CJ., Free PMC Article | 06/20/2020 |
| In summary, the authors show here that hepatitis C virus infection is associated with an upregulation of ARF4, which promotes hepatitis C virus replication. Upon hepatitis C virus infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. | Interplay between hepatitis C virus and ARF4.
Zhang N, Ke Y, Zhang L., Free PMC Article | 07/28/2018 |
| found ADP-ribosylation factor (ARF) 4 is one of the putative target genes of Mir-221, and the direct binding relationship was further confirmed by dual-luciferase reporter assay. | MiR-221-3p targets ARF4 and inhibits the proliferation and migration of epithelial ovarian cancer cells.
Wu Q, Ren X, Zhang Y, Fu X, Li Y, Peng Y, Xiao Q, Li T, Ouyang C, Hu Y, Zhang Y, Zhou W, Yan W, Guo K, Li W, Hu Y, Yang X, Shu G, Xue H, Wei Z, Luo Y, Yin G. | 04/14/2018 |
| Data suggest that, when compared to intestinal epithelial cells (IECs) from germ-free mice, IECs from mice with commensal bacteria exhibit increased expression of microRNA-21-5p; up-regulation of expression of microRNA-21-5p appears to increase IEC permeability and up-regulates ADP ribosylation factor 4 (Arf4/ARF4) in mouse and human cells. | Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4.
Nakata K, Sugi Y, Narabayashi H, Kobayakawa T, Nakanishi Y, Tsuda M, Hosono A, Kaminogawa S, Hanazawa S, Takahashi K., Free PMC Article | 09/30/2017 |
| ARF1+ARF4 are required for integrity of recycling endosomes but are involved in distinct transport pathways: the pair regulates retrograde transport from endosomes to the TGN. | ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.
Nakai W, Kondo Y, Saitoh A, Naito T, Nakayama K, Shin HW., Free PMC Article | 04/5/2014 |
| A CREB3-ARF4 signalling cascade may be part of a Golgi stress response set in motion by stimuli compromising Golgi capacity. | A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.
Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM., Free PMC Article | 02/8/2014 |
| a crucial role for class II Arf proteins (Arf4 and Arf5) in the dengue flavivirus life cycle | Class II ADP-ribosylation factors are required for efficient secretion of dengue viruses.
Kudelko M, Brault JB, Kwok K, Li MY, Pardigon N, Peiris JSM, Bruzzone R, Desprès P, Nal B, Wang PG., Free PMC Article | 05/12/2012 |
| The lipid droplets deposition and the cellular triacylglycerol content are significantly increased by siRNA-mediated depletion of Arf4. | GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis.
Takashima K, Saitoh A, Hirose S, Nakai W, Kondo Y, Takasu Y, Kakeya H, Shin HW, Nakayama K. | 04/14/2012 |
| sLZIP-regulated ARF4 expression in response to phorbol 12-myristate 13-acetate is involved in breast cancer cell migration. | Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration.
Jang SY, Jang SW, Ko J. | 01/14/2012 |
| Arf4 regulates PLA2G6-A activity together with Arf1; and gene silencing of Arf4 was shown to alter cytosolic coat protein I subunit recruitment to the early secretory pathway. | ADP ribosylation factors 1 and 4 and group VIA phospholipase A₂ regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment.
Ben-Tekaya H, Kahn RA, Hauri HP., Free PMC Article | 06/25/2011 |
| ARF4 participates in the regulation of glioblastoma apoptosis through the inhibition of stress-mediated apoptotic signals | Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death.
Woo IS, Eun SY, Jang HS, Kang ES, Kim GH, Kim HJ, Lee JH, Chang KC, Kim JH, Han CW, Seo HG. | 01/21/2010 |
| ARF4L occurred on the plasma membrane after binding to GTP and into endosomes while binding to GDP; the inactive form of ARF4L causes localization of transferrin receptors to the endosomes while the active form causes transport to the plasma membrane. | Role of ARF4L in recycling between endosomes and the plasma membrane.
Katayama T, Imaizumi K, Yoneda T, Taniguchi M, Honda A, Manabe T, Hitomi J, Oono K, Baba K, Miyata S, Matsuzaki S, Takatsuji K, Tohyama M. | 01/21/2010 |
| ARF4 is a critical molecule that directly regulates cellular phospholipase D2 activity and this ARF4-mediated PLD2 activation stimulates AP-1-dependent transcription in the EGF-induced cellular response | ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation.
Kim SW, Hayashi M, Lo JF, Yang Y, Yoo JS, Lee JD. | 01/21/2010 |