| Epigenetic dissection of human blood group genes reveals regulatory elements and detailed characteristics of KEL and four other loci. | Epigenetic dissection of human blood group genes reveals regulatory elements and detailed characteristics of KEL and four other loci.
Wu PC, McGowan EC, Lee YQ, Ghosh S, Hansson J, Olsson ML. | 06/10/2024 |
| Novel KEL allele associated with loss of Kp(b) identified in a white blood donor. | Novel KEL allele associated with loss of Kp(b) identified in a white blood donor.
Yearout S, Smith A, Keller J, Keller MA. | 07/30/2022 |
| Functional Evaluation of KEL as an Oncogenic Gene in the Progression of Acute Erythroleukemia. | Functional Evaluation of KEL as an Oncogenic Gene in the Progression of Acute Erythroleukemia.
Liu W, Wu Z, Yu Y, Qiao C, Zhu H, Hong M, Zhu Y, Qian S, Chen S, Wu D, Li J, Jin H., Free PMC Article | 03/19/2022 |
| Novel KEL*02N allele in Saudi Arabia encoding a Kell null (K0 ) phenotype. | Novel KEL*02N allele in Saudi Arabia encoding a Kell null (K(0) ) phenotype.
Albasri J, Alsuhaibani O, Almarry N, Ochoa-Garay G, Bensing KM, Biese D, Knier M, Denomme GA. | 08/14/2021 |
| HLA-DRB1 molecules and the presentation of anchor peptides from RhD, RhCE, and KEL proteins. | HLA-DRB1 molecules and the presentation of anchor peptides from RhD, RhCE, and KEL proteins.
De Souza CP, Baleotti W, Moritz E, Sanches S, Lopes LB, Chiba AK, Donadi EA, Bordin JO. | 07/31/2021 |
| Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program. | Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program.
Dinardo CL, Oliveira TGM, Kelly S, Ashley-Koch A, Telen M, Schmidt LC, Castilho S, Melo K, Dezan MR, Wheeler MM, Johnsen JM, Nickerson DA, Jain D, Custer B, Pereira AC, Sabino EC, NHLBI Recipient Epidemiology Donor Evaluation Study (REDS-III) International Component-Brazil, the Outcome Modifying Genes in SCD (OMG) study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program Sickle Cell Disease Working Group. | 07/10/2021 |
| Identification of a novel null allele of the KEL gene in a Korean patient with the Kell null phenotype. | Identification of a novel null allele of the KEL gene in a Korean patient with the Kell null phenotype.
Kim TY, Kim H, Hong YJ, Park KU. | 06/26/2021 |
| Leucoreduced red blood cells from transgenic mouse donors expressing high levels of the human KEL glycoprotein in an erythrocyte-specific manner (KEL(hi) donors) were transfused after the platelets, and anti-KEL responses were measured. Transfusion of platelets from wild-type C57BL/6 donors prior to KELhi red blood cell transfusion enhances the anti-KEL alloimmune response. | Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model.
Madrid DJ, Santhanakrishnan M, Liu J, Gibb DR, Liu D, Natarajan P, Beitler D, Shi Z, Mo C, Tormey CA, Patel SR, Stowell SR, Hendrickson JE., Free PMC Article | 03/7/2020 |
| Ten new silent KEL alleles were identified in Japanese individuals with the Ko phenotype. | Silent KEL alleles identified from Japanese individuals with the K(o) phenotype.
Onodera T, Kawai M, Obara K, Enomoto T, Sasaki K, Osabe T, Ogasawara K, Toyoda C, Tsuneyama H, Uchikawa M, Inaba S, Satake M. | 09/1/2018 |
| description of four new KEL*01M alleles | New KEL*01M and KEL*02M alleles: structural modeling to assess the impact of amino acid changes.
Silvy M, Callebaut I, Filosa L, Granier T, Chiaroni J, Bailly P. | 07/1/2017 |
| The expression of Kell glycoprotein on RBCs is not critical to the erythrocyte function | Kell and Kx blood group systems.
Denomme GA. | 11/14/2015 |
| Through molecular genotyping we also identified polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients. | Erythrocyte genotyping for transfusion-dependent patients at the Azienda Universitaria Policlinico of Naples.
Belsito A, Costa D, Fiorito C, De Iorio G, Casamassimi A, Perrotta S, Napoli C. | 09/26/2015 |
| A relatively increased KEL1 antigen expression in KEL:1,2null and KEL:1,2mod individuals suggest that the expression of Kell-XK complexes depends on the availability of the XK protein. | Novel alleles at the Kell blood group locus that lead to Kell variant phenotype in the Dutch population.
Ji Y, Veldhuisen B, Ligthart P, Haer-Wigman L, Jongerius J, Boujnan M, Ait Soussan A, Luo G, Fu Y, van der Schoot CE, de Haas M. | 04/11/2015 |
| High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles. | High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles.
Meyer S, Vollmert C, Trost N, Brönnimann C, Gottschalk J, Buser A, Frey BM, Gassner C. | 02/14/2015 |
| After sequencing the whole KEL gene, we found three new missense mutations: c.455A>G (p.Tyr152Cys) at Exon 5, c.2111A>C (p.Pro704His) at Exon 19, and c.1726G>C (p.Gly576Arg) at Exon 16. | Three missense mutations found in the KEL gene lead to K(mod) or K0 red blood cell phenotypes.
Matteocci A, Mancuso T, Moscetti A, Collaretti A, Castagna K, Spaccino C, Hutchinson T, Grammatico P, Pierelli L. | 02/14/2015 |
| A new allele, KEL(Thr193Met, Pro326Leu), has a drastic effect on the Kell glycoprotein probably due to defects in protein trafficking or reduced membrane integration. | Identification of a novel Kmod -1 allele encoded by 977C>T (Pro326Leu).
Polin H, Gaszner W, Suessner S, Danzer M, Gabriel C. | 10/18/2014 |
| Sequence analysis of genomic DNA from 2 Caucasian Brazilian women revealed a new homozygous change in KEL Exon 2, a guanine to an adenine substitution at Position 71 (c.71G>A, NCBI_ss#: 831878329) leading to a premature stop codon. | Two novel KEL alleles encoding K0 phenotypes in Brazilians.
Arnoni CP, Gazito D, Muniz JG, Person Rde M, Brandão F, Marques MG, Barreto JA, Castilho L, Latini FR. | 10/18/2014 |
| A compensatory mechanism of the KELmod allele deficient expression in heterozygote patients may exist. Retrospective analysis of 80,000 subjects showed a local KEL:1,-2 frequency 4 times lower than expected. | [A KEL*02mod allele responsible for an apparent maternity exclusion].
Monfort M, Peyrard T, Arnaud L, Helias V, Maggipinto G, Gérard C. | 07/26/2014 |
| A rare allele in this family has been numbered KEL*02M.04 and contains a Gly703Arg substitution that appears to cause weakened expression of Kell antigens and a Kmod phenotype when in trans with a null allele in the propositus. | Three uncommon KEL alleles in one family with unusual Kell phenotypes explain a 35-year old conundrum.
Karamatic Crew V, Poole J, Burton N, Daniels G. | 06/7/2014 |
| Systematic DNA analysis showed that the number of discordant phenotype/genotype results, related to silent KEL*02 alleles was higher than expected in France. | Identification of novel silent KEL alleles causing KEL:-5 (Ko) phenotype or discordance between KEL:1,-2 phenotype/KEL*01/02 genotype.
Martin-Blanc S, Simon P, Gien D, Kappler-Gratias S, Le Pennec PY, Pham BN. | 02/1/2014 |
| These findings identify the translational start site and define the full cytoplasmic tail of the human Kell glycoprotein. | Resolution of translation start site for the human Kell glycoprotein.
Blacken GR, Zimring JC, Fu X. | 02/1/2014 |
| Novel IVS6-13C>T mutation recognized as a cause of discrepancy between phenotyping and genotyping in KEL*3,4 polymorphism identification. | Novel IVS6-13C>T mutation recognized as a cause of discrepancy between phenotyping and genotyping in KEL*3,4 polymorphism identification.
Boturão-Neto E, Chiba AK, Bordin JO. | 08/2/2010 |
| In screening 87665 unrelated healthy blood donors in China, two K(0) probands were detected; in exon 3, 185insT (Ser62Phe and a premature stop codon in exon 4 | Two novel null alleles of the KEL gene detected in two Chinese women with the K(null) phenotype.
Yang Y, Wang L, Wang C, Chen H, Guo Z, Zhang Y, Zhu Z. | 01/21/2010 |
| This is the first description of the KEL*1,3 allele encoding KEL1 and KEL3 on the same molecule. | A novel KEL*1,3 allele with weak Kell antigen expression confirming the cis-modifier effect of KEL3.
Körmöczi GF, Scharberg EA, Gassner C. | 01/21/2010 |
| Observational study of genetic testing. (HuGE Navigator) | See all PubMed (3) articlesSingle PCR multiplex SNaPshot reaction for detection of eleven blood group nucleotide polymorphisms: optimization, validation, and one year of routine clinical use.
Di Cristofaro J, Silvy M, Chiaroni J, Bailly P. Introduction of a real-time-based blood-group genotyping approach.
Polin H, Danzer M, Pröll J, Hofer K, Heilinger U, Zopf A, Gabriel C. Blood group genotyping for Jk(a)/Jk(b), Fy(a)/Fy(b), S/s, K/k, Kp(a)/Kp(b), Js(a)/Js(b), Co(a)/Co(b), and Lu(a)/Lu(b) with microarray beads.
Karpasitou K, Drago F, Crespiatico L, Paccapelo C, Truglio F, Frison S, Scalamogna M, Poli F. | 03/13/2008 |