| KIR2DL1 gene is a surrogate marker of protection against infection-related hospitalization among HIV-1 unexposed versus exposed uninfected infants in Cameroon. | KIR2DL1 gene is a surrogate marker of protection against infection-related hospitalization among HIV-1 unexposed versus exposed uninfected infants in Cameroon.
Simeni LK, Ekali GL, Yengo CK, Wouambo RK, Fischer J, Bessong OMA, Fokam J, Yindom LM, Nguedia JCA., Free PMC Article | 08/2/2024 |
| Activating KIR/HLA-I combinations as a risk factor of adult B-ALL. | Activating KIR/HLA-I combinations as a risk factor of adult B-ALL.
Halimi H, Mirzazadeh S, Kalantar K, Hajimaghsoodi M, Ramzi M, Farjadian S. | 06/9/2024 |
| KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity. | KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity.
Leijonhufvud C, Sanz-Ortega L, Schlums H, Gaballa A, Andersson A, Eriksson C, Segerberg F, Uhlin M, Bryceson YT, Carlsten M. | 02/23/2024 |
| The KIR2DL1 intermediate upstream element participates in gene activation. | The KIR2DL1 intermediate upstream element participates in gene activation.
Wright PW, Li H, Rahman MA, Anderson EM, Karwan M, Carrell J, Anderson SK., Free PMC Article | 12/6/2023 |
| Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure. | Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.
Woon EV, Nikolaou D, MacLaran K, Norman-Taylor J, Bhagwat P, Cuff AO, Johnson MR, Male V., Free PMC Article | 02/4/2023 |
| Lack of association of KIR2DL1-R(245) and KIR2DL1-C(245) with HIV-1 control in black South Africans with HLA-C2. | Lack of association of KIR2DL1-R(245) and KIR2DL1-C(245) with HIV-1 control in black South Africans with HLA-C2.
Loubser S, Da Costa Dias B, Shalekoff S, Gentle NL, Tiemessen CT. | 01/1/2022 |
| Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations. | Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations.
Vargas LB, Dourado RM, Amorim LM, Ho B, Calonga-Solís V, Issler HC, Marin WM, Beltrame MH, Petzl-Erler ML, Hollenbach JA, Augusto DG., Free PMC Article | 04/17/2021 |
| The strong interaction of KIR2DL1 and HLA-C2 ligands seems to promote large and stable expansion of adaptive NK cells in Human Cytomegalovirus (HCMV) infection. | KIR Polymorphism Modulates the Size of the Adaptive NK Cell Pool in Human Cytomegalovirus-Infected Individuals.
Manser AR, Scherenschlich N, Thöns C, Hengel H, Timm J, Uhrberg M. | 05/23/2020 |
| More NK cells educated through KIR2DL1 and KIR3DL1, but not KIR2DL3, responded to antibody-dependent (AD) NK cell activation than their uneducated counterparts. | Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC.
Lisovsky I, Kant S, Tremblay-McLean A, Isitman G, Kiani Z, Dupuy FP, Gilbert L, Bruneau J, Shoukry NH, Lebouché B, Bernard NF., Free PMC Article | 10/19/2019 |
| matching of KIR2DL1, 2DS1, and 2DS2 in donors with their HLA-C ligands in recipients is associated with increased GvHD, and holds potential for selection of HSCT donors. | Prognostic role of KIR genes and HLA-C after hematopoietic stem cell transplantation in a patient cohort with acute myeloid leukemia from a consanguineous community.
Gaafar A, Sheereen A, Almohareb F, Eldali A, Chaudhri N, Mohamed SY, Hanbali A, Shaheen M, Alfraih F, El Fakih R, Iqneibi A, Youniss R, Elhassan T, Hashmi S, Aljurf M, Alhussein K. | 09/28/2019 |
| In a case-control study of pre-eclampsia, the authors show that KIR2DL1A, not KIR2DL1B, associates with increased Pre-Eclampsia disease risk. | High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia.
Huhn O, Chazara O, Ivarsson MA, Retière C, Venkatesan TC, Norman PJ, Hilton HG, Jayaraman J, Traherne JA, Trowsdale J, Ito M, Kling C, Parham P, Ghadially H, Moffett A, Sharkey AM, Colucci F., Free PMC Article | 07/20/2019 |
| Distinguishing these haplotypes are independent mutations in KIR2DL1. | Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2(+) HLA-C in Two Indigenous Human Populations in Southern Africa.
Nemat-Gorgani N, Hilton HG, Henn BM, Lin M, Gignoux CR, Myrick JW, Werely CJ, Granka JM, Möller M, Hoal EG, Yawata M, Yawata N, Boelen L, Asquith B, Parham P, Norman PJ., Free PMC Article | 04/13/2019 |
| KIR 2D (L1, L3, L4, S4) and KIR 3DL1 expression was correlated with poor prognosis in non-small cell lung carcinoma patients. | KIR 2D (L1, L3, L4, S4) and KIR 3DL1 protein expression in non-small cell lung cancer.
He Y, Bunn PA, Zhou C, Chan D., Free PMC Article | 02/17/2018 |
| A negative association between the KIR2DL1 polymorphism and susceptibility to type 1 diabetes mellitus was found. | Association between KIR gene polymorphisms and type 1 diabetes mellitus (T1DM) susceptibility: A PRISMA-compliant meta-analysis.
Liu SL, Zheng AJ, Ding L., Free PMC Article | 02/10/2018 |
| the surface organization of paired killer Ig-like receptors (KIR), KIR2DL1 and KIR2DS1, on human primary natural killer cells and cell lines, was examined. | The Size of Activating and Inhibitory Killer Ig-like Receptor Nanoclusters Is Controlled by the Transmembrane Sequence and Affects Signaling.
Oszmiana A, Williamson DJ, Cordoba SP, Morgan DJ, Kennedy PR, Stacey K, Davis DM., Free PMC Article | 11/26/2017 |
| A significantly higher risk of chronic rejection after kidney transplantation was observed when recipient (r) and donor (d) pairs completely lacked the two functional rKIR-dHLA ligand combinations rKIR2DL1/dHLA-C2 and rKIR3DL1/dHLA-Bw4. | KIR and their HLA Class I ligands: Two more pieces towards completing the puzzle of chronic rejection and graft loss in kidney transplantation.
Littera R, Piredda G, Argiolas D, Lai S, Congeddu E, Ragatzu P, Melis M, Carta E, Michittu MB, Valentini D, Cappai L, Porcella R, Alba F, Serra M, Loi V, Maddi R, Orrù S, La Nasa G, Caocci G, Cusano R, Arras M, Frongia M, Pani A, Carcassi C., Free PMC Article | 09/23/2017 |
| CD16+ cells were significantly more frequent among Natural Killer (NK) cells negative for the inhibitory KIR (iKIR) KIR2DL1, KIR2DL3, and KIR3DL1 than those positive for any one of these iKIR to the exclusion of the others, making iKIR+ NK cells poorer antibody dependent cellular cytotoxicity effectors than iKIR- NK cells. | NK Cells Expressing the Inhibitory Killer Immunoglobulin-Like Receptors (iKIR) KIR2DL1, KIR2DL3 and KIR3DL1 Are Less Likely to Be CD16+ than Their iKIR Negative Counterparts.
Isitman G, Tremblay-McLean A, Lisovsky I, Bruneau J, Lebouché B, Routy JP, Bernard NF., Free PMC Article | 06/3/2017 |
| Data indicate that a novel variant allele, KIR2DL1*031, was identified by cDNA cloning and haplotype sequencing of killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) gene. | [Cloning and sequencing of KIR2DL1 framework gene cDNA and identification of a novel allele].
Sun G, Wang C, Zhen J, Zhang G, Xu Y, Deng Z. | 01/14/2017 |
| KIR2DL1-C2C2 is less frequent in type 1 diabetes in Saudi children | Investigation of activating and inhibitory killer cell immunoglobulin-like receptors and their putative ligands in type 1 diabetes (T1D).
Osman AE, Eltayeb-ELSheikh N, Mubasher M, Al Harthi H, Alharbi S, Hamza MA, ElGhazali G. | 11/12/2016 |
| Influence of Differently Licensed KIR2DL1-Positive Natural Killer Cells in Transplant Recipients with Acute Leukemia | Influence of Differently Licensed KIR2DL1-Positive Natural Killer Cells in Transplant Recipients with Acute Leukemia: A Japanese National Registry Study.
Arima N, Nakamura F, Yabe T, Tanaka J, Fuji S, Ohashi K, Fukuda T, Miyamura K, Iwato K, Eto T, Mori T, Kobayashi N, Hoshino T, Kato C, Kanamori H, Nakamae H, Atsuta Y, Morishima Y, Kanda Y. | 10/29/2016 |
| Educated natural killer cells expressing KIR2DL1 display functional advantage for anti-HIV-1 antibody-dependent activation. | Functional advantage of educated KIR2DL1(+) natural killer cells for anti-HIV-1 antibody-dependent activation.
Gooneratne SL, Center RJ, Kent SJ, Parsons MS., Free PMC Article | 07/30/2016 |
| KIR2DL1*022 and 2DL1*026 evolved in the KhoeSan after their divergence from other modern human populations. | Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population.
Hilton HG, Norman PJ, Nemat-Gorgani N, Goyos A, Hollenbach JA, Henn BM, Gignoux CR, Guethlein LA, Parham P., Free PMC Article | 05/14/2016 |
| Data suggest regulatory interactions between major histocompatibility antigen HLA-C and killer cell Ig-like receptor (KIR) might promote Graft-versus-Leukemia effects following transplantation. | Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation.
Horowitz A, Guethlein LA, Nemat-Gorgani N, Norman PJ, Cooley S, Miller JS, Parham P., Free PMC Article | 04/2/2016 |
| Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein. | NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.
Anton OM, Vielkind S, Peterson ME, Tagaya Y, Long EO., Free PMC Article | 02/27/2016 |
| genetic association studies in Chinese Han population: Data suggest that the frequency of KIR2DL1 gene is increased in women with pre-eclampsia when homozygous HLA-C2 allele appears in the fetus. | Association of maternal KIR and fetal HLA-C genes with the risk of preeclampsia in the Chinese Han population.
Long W, Shi Z, Fan S, Liu L, Lu Y, Guo X, Rong C, Cui X, Ding H. | 12/12/2015 |