| OLFM4 modulates intestinal inflammation by promoting IL-22[+]ILC3 in the gut. | OLFM4 modulates intestinal inflammation by promoting IL-22(+)ILC3 in the gut.
Xing Z, Li X, He J, Chen Y, Zhu L, Zhang X, Huang Z, Tang J, Guo Y, He Y., Free PMC Article | 09/6/2024 |
| Blocking OLFM4/galectin-3 axis in placental polymorphonuclear myeloid-derived suppressor cells triggers intestinal inflammation in newborns. | Blocking OLFM4/galectin-3 axis in placental polymorphonuclear myeloid-derived suppressor cells triggers intestinal inflammation in newborns.
Lv S, Chen M, Li Z, Huang Z, Wan S, Kuang S, Peng L, Ye J, Yang M, Li J, He Y. | 06/17/2024 |
| Olfactomedin-4 deletion exacerbates DSS-induced colitis through a matrix metalloproteinase-9-dependent mechanism. | Olfactomedin-4 deletion exacerbates DSS-induced colitis through a matrix metalloproteinase-9-dependent mechanism.
Wang X, Chen S, Wang J, Chen Y, Guo Y, Wang Q, Liu Z, Zeng H, Xu C., Free PMC Article | 05/15/2023 |
| OLFM4 deficiency delays the progression of colitis to colorectal cancer by abrogating PMN-MDSCs recruitment. | OLFM4 deficiency delays the progression of colitis to colorectal cancer by abrogating PMN-MDSCs recruitment.
Chen Z, Zhang X, Xing Z, Lv S, Huang L, Liu J, Ye S, Li X, Chen M, Zuo S, Tao Y, He Y. | 06/11/2022 |
| These results demonstrate renal expression of OLFM4 for the first time and suggest that a kidney-specific mechanism may contribute to survival differences in OLFM4-null animals. | Juvenile OLFM4-null mice are protected from sepsis.
Stark JE, Opoka AM, Mallela J, Devarajan P, Ma Q, Levinsky NC, Stringer KF, Wong HR, Alder MN., Free PMC Article | 07/18/2020 |
| High OLFM4 expression is associated with intestinal ischemia/reperfusion injury. | The olfactomedin-4 positive neutrophil has a role in murine intestinal ischemia/reperfusion injury.
Levinsky NC, Mallela J, Opoka AM, Harmon K, Lewis HV, Zingarelli B, Wong HR, Alder MN., Free PMC Article | 06/13/2020 |
| Olfm4 contributes to H2O2-induced NADPH oxidase activation. | Olfactomedin 4 contributes to hydrogen peroxide-induced NADPH oxidase activation and apoptosis in mouse neutrophils.
Liu W, Liu Y, Li H, Rodgers GP., Free PMC Article | 07/6/2019 |
| Studies suggest that Olfm4 negatively regulates glucose-stimulated insulin secretion. | Olfactomedin 4 Deletion Improves Male Mouse Glucose Intolerance and Insulin Resistance Induced by a High-Fat Diet.
Liu W, Aerbajinai W, Li H, Liu Y, Gavrilova O, Jain S, Rodgers GP., Free PMC Article | 03/9/2019 |
| OLFM4 has an important role in the regulation of intestinal inflammation and tumorigenesis, and could be a potential therapeutic target for intestinal malignant tumors. Unlike the human colonic epithelium, the mouse colonic epithelium does not express OLFM4, but nevertheless, systemic OLFM4 deletion promotes colon tumorigenesis and that loss from mucosal neutrophils may have a role to play. | Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice.
Liu W, Li H, Hong SH, Piszczek GP, Chen W, Rodgers GP., Free PMC Article | 09/2/2017 |
| olfactomedin 4 appears to play a critical role in regulating progression of prostate cancer, and has potential as a new biomarker for prostate cancer. | Olfactomedin 4 deficiency promotes prostate neoplastic progression and is associated with upregulation of the hedgehog-signaling pathway.
Li H, Liu W, Chen W, Zhu J, Deng CX, Rodgers GP., Free PMC Article | 09/17/2016 |
| OLFM4 may function as a tumor suppressor and an anti-metastatic gene during tumor progression | Olfactomedin 4 suppresses tumor growth and metastasis of mouse melanoma cells through downregulation of integrin and MMP genes.
Park KS, Kim KK, Piao ZH, Kim MK, Lee HJ, Kim YC, Lee KS, Lee JH, Kim KE., Free PMC Article | 11/30/2013 |
| Olfm4 deletion can successfully enhance immune defense against S. aureus, but not A. fumigatus, in chronic granulomatous disease mice. | Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease.
Liu W, Yan M, Sugui JA, Li H, Xu C, Joo J, Kwon-Chung KJ, Coleman WG, Rodgers GP., Free PMC Article | 11/30/2013 |
| OLFM4 exerts considerable influence on the host defense against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response. | Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection.
Liu W, Yan M, Liu Y, Wang R, Li C, Deng C, Singh A, Coleman WG Jr, Rodgers GP., Free PMC Article | 07/19/2010 |
| a novel PU.1-regulated extracellular glycoprotein of the olfactomedin-like family has a possible role in neutrophilic trafficking.(pdp4) | pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1.
Rosenbauer F, Wagner K, Zhang P, Knobeloch KP, Iwama A, Tenen DG. | 01/21/2010 |