| Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons. | Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.
Yi J, Bertels Z, Del Rosario JS, Widman AJ, Slivicki RA, Payne M, Susser HM, Copits BA, Gereau RW 4th., Free PMC Article | 12/22/2023 |
| An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons alpha and lambda1 in HBV infection by promoting MAVS lysosomal degradation. | An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation.
Zhang B, Han H, Zhao X, Li AN, Wang Y, Yuan W, Yang Z, Li MD., Free PMC Article | 08/16/2023 |
| High preoperative bradykinin level is a risk factor for severe postoperative hypoxaemia in acute aortic dissection surgery. | High preoperative bradykinin level is a risk factor for severe postoperative hypoxaemia in acute aortic dissection surgery.
Guan X, Li L, Li J, Jiang W, Li H, Wang X, Han L, Liu Y, Gong M, Zhang H., Free PMC Article | 05/8/2023 |
| gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema. | gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema.
Fandaros M, Joseph K, Kaplan AP, Rubenstein DA, Ghebrehiwet B, Yin W. | 03/26/2022 |
| Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure. | Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.
Henderson MW, Sparkenbaugh EM, Wang S, Ilich A, Noubouossie DF, Mailer R, Renné T, Flick MJ, Luyendyk JP, Chen ZL, Strickland S, Stravitz RT, McCrae KR, Key NS, Pawlinski R., Free PMC Article | 12/11/2021 |
| Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis. | Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.
Köhler J, Maletzki C, Koczan D, Frank M, Springer A, Steffen C, Revenko AS, MacLeod AR, Mikkat S, Kreikemeyer B, Oehmcke-Hecht S., Free PMC Article | 06/12/2021 |
| Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson's Disease. | Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson's Disease.
Markaki I, Bergström S, Tsitsi P, Remnestål J, Månberg A, Hertz E, Paslawski W, Sorjonen K, Uhlén M, Mangone G, Carvalho S, Rascol O, Meissner WG, Magnin E, Wüllner U, Corvol JC, Nilsson P, Svenningsson P. | 05/8/2021 |
| Bradykinin stimulates prostaglandin E2 release in human skeletal muscular fibroblasts. | Bradykinin stimulates prostaglandin E(2) release in human skeletal muscular fibroblasts.
Muscella A, Cossa LG, Vetrugno C, Marsigliante S. | 05/1/2021 |
| Pathways for bradykinin formation and interrelationship with complement as a cause of edematous lung in COVID-19 patients. | Pathways for bradykinin formation and interrelationship with complement as a cause of edematous lung in COVID-19 patients.
Kaplan AP, Ghebrehiwet B., Free PMC Article | 02/20/2021 |
| Bradykinin and oxidative stress in patients with hereditary angioedema due to C1 inhibitor deficiency. | Bradykinin and oxidative stress in patients with hereditary angioedema due to C1 inhibitor deficiency.
Obtułowicz K, Góralska J, Bogdali A, Dyga W, Obtułowicz A, Myszkowska D, Ziemianin M, Gruca A, Solnica B, Czarnobilska E. | 01/30/2021 |
| Differential processing of high-molecular-weight kininogen during normal pregnancy. | Differential processing of high-molecular-weight kininogen during normal pregnancy.
Droll SH, Hsu YS, Drake SK, Kim A, Wang W, Calvo KR, Cao Z, Hu TY, Zhao Z., Free PMC Article | 01/9/2021 |
| Evaluation of potential cardiovascular risk protein biomarkers in high severity restless legs syndrome. | Evaluation of potential cardiovascular risk protein biomarkers in high severity restless legs syndrome.
Bellei E, Bergamini S, Monari E, Tomasi A, Koseoglu M, Topaloglu Tuac S, Ozben S. | 08/29/2020 |
| A vicious positive feedback loop of des-Arg(9)-bradykinin- and bradykinin-mediated inflammation --> injury --> inflammation, likely precipitates life threatening respiratory complications in COVID-19. | A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications.
Roche JA, Roche R., Free PMC Article | 07/4/2020 |
| Plasma high molecular weight kininogen and prekallikrein concentrations were not associated with incident cardiovascular disease. | Prospective study of plasma high molecular weight kininogen and prekallikrein and incidence of coronary heart disease, ischemic stroke and heart failure.
Parikh RR, Folsom AR, Misialek JR, Rosamond WD, Chang PP, Tang W, Cushman M., Free PMC Article | 05/2/2020 |
| Fibrinogen and kininogen may be potential serum protein biomarkers in the diagnosis and prognosis of depressive disorders. | Fibrinogen and Kininogen are Potential Serum Protein Biomarkers for Depressive Disorder.
Kang G, Zhang Y, Liu R, Li R, Kang Q, Zhu X, Yan L, Yu Y, Yu Q. | 03/14/2020 |
| Data found that the serum BK levels and the levels of its receptor, B2R, were overexpressed in patients with cervical cancer (CC). BK promotes the development of CC may be the upregulation of VEGF expression, thus accelerating angiogenesis through B2R. | Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2.
Zhou Y, Wang W, Wei R, Jiang G, Li F, Chen X, Wang X, Long S, Ma D, Xi L., Free PMC Article | 12/21/2019 |
| KNG1 role in the genetic predisposition to the deep venous thrombosis after orthopedic surgery in the Han Chinese population . | Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator.
Wang Q, Cheng G, Wang X, Wang D, Yang Y, Chen K, Ye J, Qing Z., Free PMC Article | 12/14/2019 |
| KNG1 was identified as the core gene and lowly expressed in the glioma cells. Overexpression of KNG1 inhibited cell viability and angiogenesis of glioma cells. Overexpression of KNG1 promoted the apoptosis and G1 phase cell cycle arrest of glioma cells. | Overexpression of the Kininogen-1 inhibits proliferation and induces apoptosis of glioma cells.
Xu J, Fang J, Cheng Z, Fan L, Hu W, Zhou F, Shen H., Free PMC Article | 03/30/2019 |
| Bradykinin is expressed in endometriotic lesions. | Bradykinin system is involved in endometriosis-related pain through endothelin-1 production.
Yoshino O, Yamada-Nomoto K, Kobayashi M, Andoh T, Hongo M, Ono Y, Hasegawa-Idemitsu A, Sakai A, Osuga Y, Saito S. | 01/12/2019 |
| Kininogen binds to the cell surface-exposed proteins of Candida parapsilosis. | Binding of human plasminogen and high-molecular-mass kininogen by cell surface-exposed proteins of Candida parapsilosis.
Karkowska-Kuleta J, Zajac D, Bras G, Bochenska O, Rapala-Kozik M, Kozik A. | 03/3/2018 |
| Three loci showed robust, replicating association with circulating FXI levels: KNG1 (rs710446, P-value = 2.07 x 10-302), F11 (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin time | Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.
Sennblad B, Basu S, Mazur J, Suchon P, Martinez-Perez A, van Hylckama Vlieg A, Truong V, Li Y, Gådin JR, Tang W, Grossman V, de Haan HG, Handin N, Silveira A, Souto JC, Franco-Cereceda A, Morange PE, Gagnon F, Soria JM, Eriksson P, Hamsten A, Maegdefessel L, Rosendaal FR, Wild P, Folsom AR, Trégouët DA, Sabater-Lleal M., Free PMC Article | 09/16/2017 |
| findings show that the KNG1 locus plays a central role as a genetic determinant of the entire coagulation pathway and thrombus/clot formation | The Central Role of KNG1 Gene as a Genetic Determinant of Coagulation Pathway-Related Traits: Exploring Metaphenotypes.
Brunel H, Massanet R, Martinez-Perez A, Ziyatdinov A, Martin-Fernandez L, Souto JC, Perera A, Soria JM., Free PMC Article | 09/9/2017 |
| Urinary KNG1 and RBP4 clearly respond to AKI. Additionally, RBP4 could predict recovery by monitoring this protein levels over time after AKI, as RBP4 reflects patient's normalization earlier than sCr values do. | Urinary Kininogen-1 and Retinol binding protein-4 respond to Acute Kidney Injury: predictors of patient prognosis?
Gonzalez-Calero L, Martin-Lorenzo M, Ramos-Barron A, Ruiz-Criado J, Maroto AS, Ortiz A, Gomez-Alamillo C, Arias M, Vivanco F, Alvarez-Llamas G., Free PMC Article | 01/14/2017 |
| KNG1 rs710446/ rs2304456 SNPs are not related to the incidence of Alzheimer's disease in a Hunan Han Chinese population. | Relationship between the gene polymorphisms of kallikrein-kinin system and Alzheimer's disease in a Hunan Han Chinese population.
Deng Y, Hou D, Tian M, Li W, Feng X, Yu Z., Free PMC Article | 11/12/2016 |
| Low urine KNG1 expression is associated with clear cell renal cell carcinoma. | Proteomic analysis reveals differentially secreted proteins in the urine from patients with clear cell renal cell carcinoma.
Sandim V, Pereira Dde A, Kalume DE, Oliveira-Carvalho AL, Ornellas AA, Soares MR, Alves G, Zingali RB. | 10/1/2016 |