| Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis. | Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.
Li J, Zhang B, Feng Z, An D, Zhou Z, Wan C, Hu Y, Sun Y, Wang Y, Liu X, Wei W, Yang X, Meng J, Che M, Sheng Y, Wu B, Wen L, Huang F, Li Y, Yang K., Free PMC Article | 02/12/2024 |
| Human RTEL1 Interacts with KPNB1 (Importin beta) and NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in S-Phase. | Human RTEL1 Interacts with KPNB1 (Importin β) and NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in S-Phase.
Schertzer M, Jullien L, Pinto AL, Calado RT, Revy P, Londoño-Vallejo A., Free PMC Article | 01/3/2024 |
| MicroRNA-130a-3p impedes the progression of papillary thyroid carcinoma through downregulation of KPNB1 by targeting PSME3. | MicroRNA-130a-3p impedes the progression of papillary thyroid carcinoma through downregulation of KPNB1 by targeting PSME3.
Wang Y, Xu J, Zhu X, Kuang H. | 08/30/2023 |
| KPNB1-mediated nuclear import in cancer. | KPNB1-mediated nuclear import in cancer.
Shi Q, Lin M, Cheng X, Zhang Z, Deng S, Lang K, Yang Z, Sun X. | 08/17/2023 |
| Tumor-promoting properties of karyopherin beta1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1. | Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1.
Yang F, Li L, Mu Z, Liu P, Wang Y, Zhang Y, Han X., Free PMC Article | 12/24/2022 |
| A mass spectrometry-based approach for the identification of Kpnbeta1 binding partners in cancer cells. | A mass spectrometry-based approach for the identification of Kpnβ1 binding partners in cancer cells.
Okpara MO, Hermann C, van der Watt PJ, Garnett S, Blackburn JM, Leaner VD., Free PMC Article | 12/3/2022 |
| CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-alpha/NF-kappaB signaling. | CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-α/NF-κB signaling.
Jiang Y, Zhao J, Liu Y, Hu J, Gao L, Wang H, Cui D., Free PMC Article | 08/20/2022 |
| PCDH1 promotes progression of pancreatic ductal adenocarcinoma via activation of NF-kappaB signalling by interacting with KPNB1. | PCDH1 promotes progression of pancreatic ductal adenocarcinoma via activation of NF-κB signalling by interacting with KPNB1.
Ye Z, Yang Y, Wei Y, Li L, Wang X, Zhang J., Free PMC Article | 07/30/2022 |
| Inhibition of NUPR1-Karyopherin beta1 Binding Increases Anticancer Drug Sensitivity. | Inhibition of NUPR1-Karyopherin β1 Binding Increases Anticancer Drug Sensitivity.
Park C, Oh J, Lee WM, Koh HR, Sohn UD, Ham SW, Oh K., Free PMC Article | 05/8/2021 |
| Antivirals that target the host IMPalpha/beta1-virus interface. | Antivirals that target the host IMPα/β1-virus interface.
Martin AJ, Jans DA., Free PMC Article | 03/28/2021 |
| Thioredoxin-related transmembrane protein 2 (TMX2) regulates the Ran protein gradient and importin-beta-dependent nuclear cargo transport. | Thioredoxin-related transmembrane protein 2 (TMX2) regulates the Ran protein gradient and importin-β-dependent nuclear cargo transport.
Oguro A, Imaoka S., Free PMC Article | 11/21/2020 |
| KPNA7, an isoform with expression mostly limited to early development, can bind Importin-beta (Imp-beta) in the absence of NLS cargo. | Characterization of the Importin-β binding domain in nuclear import receptor KPNA7.
Oostdyk LT, McConnell MJ, Paschal BM. | 07/11/2020 |
| KPNB1 expression was significantly increased in colorectal cancer, contributing to CRC progression and hepatic metastasis by interacting with MET to subsequently control the expression of EMT-related signals. | Karyopherin β1 deletion suppresses tumor growth and metastasis in colorectal cancer (CRC) by reducing MET expression.
Zhang Y, Li KF. | 04/25/2020 |
| Inhibition of KPNB1 could be a new therapeutic target for Prostate cancer treatment. | Inhibition of Karyopherin beta 1 suppresses prostate cancer growth.
Yang J, Guo Y, Lu C, Zhang R, Wang Y, Luo L, Zhang Y, Chu CH, Wang KJ, Obbad S, Yan W, Li X., Free PMC Article | 12/14/2019 |
| NCAM140 is translocated into the nucleus by an importin-beta1-dependent mechanism. | NCAM140 is translocated into the nucleus by an importin-β1-dependent mechanism.
Homrich M, Es-Saddiki F, Gotthard I, Laurini C, Stein E, Wobst H, Zielinski A, Diestel S. | 09/21/2019 |
| KPNB1 is a direct target of miR-101. | MiR-101 relates to chronic peripheral neuropathic pain through targeting KPNB1 and regulating NF-κB signaling.
Liu JC, Xue DF, Wang XQ, Ai DB, Qin PJ. | 08/10/2019 |
| Taken together, these results showed that full-length Pom121 enables efficient HIV-1 pre-integration complex nuclear import, and suggested that this process may rely on KPNB1 dependent classical cargo nuclear transportation way. | The transmembrane nucleoporin Pom121 ensures efficient HIV-1 pre-integration complex nuclear import.
Guo J, Liu X, Wu C, Hu J, Peng K, Wu L, Xiong S, Dong C., Free PMC Article | 05/18/2019 |
| A tight balance of Kpnbeta1 expression is required for cellular function. | A tight balance of Karyopherin β1 expression is required in cervical cancer cells.
Carden S, van der Watt P, Chi A, Ajayi-Smith A, Hadley K, Leaner VD., Free PMC Article | 03/2/2019 |
| Findings demonstrate that KPNB1 is required for proteostasis maintenance and its inhibition induces apoptosis in glioblastoma cells through UPR-mediated deregulation of Bcl-2 family members. | KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.
Zhu ZC, Liu JW, Li K, Zheng J, Xiong ZQ., Free PMC Article | 02/23/2019 |
| our findings suggest that Kpnbeta1 plays a significant role in non-small cell lung cancer progression and chemoresistance | High Kpnβ1 expression promotes non-small cell lung cancer proliferation and chemoresistance via the PI3-kinase/AKT pathway.
Wang H, Wang D, Li C, Zhang X, Zhou X, Huang J. | 09/29/2018 |
| Study identified that high expression of Kpnbeta1 in breast cancer (BC) often leads to poor prognosis and that Kpnbeta1-knockdown markedly reduced BC cell proliferation by abrogating nuclear transport of Her2. | Suppression of Kpnβ1 expression inhibits human breast cancer cell proliferation by abrogating nuclear transport of Her2.
Sheng C, Qiu J, He Z, Wang H, Wang Q, Guo Z, Zhu L, Ni Q., Free PMC Article | 08/25/2018 |
| Data suggest that IGFBP5 nuclear import is mediated by KPNA5/KPNB1 complex; nuclear localization sequence of IGFBP5 is critical domain in this nuclear translocation. (IGFBP5 = insulin-like growth factor binding protein-5; KPNA5 = karyopherin subunit alpha-5; KPNB1 = karyopherin subunit beta-1/importin-beta) | Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.
Sun M, Long J, Yi Y, Xia W. | 07/14/2018 |
| KPNB1 and Ran protein jointly mediated the nuclear import of NDV M protein, showing that KPNB1 protein interacted with NDV M protein to form binary complex and then entered into the nucleus with the assistance of Ran protein. | [The nuclear import of Newcastle disease virus matrix protein depends on KPNB1 and Ran protein].
Duan Z, Ji X, Xu J, Zhao J, Xu H, Hu S, Liu X. | 07/7/2018 |
| Results show that importin beta1 is an Epac1 binding partner that regulates Epac1 subcellular localization. | Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.
Baameur F, Singhmar P, Zhou Y, Hancock JF, Cheng X, Heijnen CJ, Kavelaars A., Free PMC Article | 05/19/2018 |
| Results found KPNB1 to be required for the migration and invasion of cervical cancer cells through mediating nuclear import. Its inhibition of KPNB1 interferes with NFkB subcellular localization. | KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells.
Stelma T, Leaner VD., Free PMC Article | 03/24/2018 |