| SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis. | SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis.
Wang XW, Jiang YH, Ye W, Shao CF, Xie JJ, Li X., Free PMC Article | 08/19/2023 |
| KPNA3 promotes epithelial-mesenchymal transition by regulating TGF-beta and AKT signaling pathways in MDA-MB-231, a triple-negative breast cancer cell line. | KPNA3 promotes epithelial-mesenchymal transition by regulating TGF-β and AKT signaling pathways in MDA-MB-231, a triple-negative breast cancer cell line.
Choi J, Choi JH, Lee HW, Seo D, Lkhagvasuren G, Kim JW, Seo SB, Lee K, Lee KH., Free PMC Article | 02/28/2023 |
| Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia. | Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.
Schob C, Hempel M, Safka Brozkova D, Jiang H, Kim SY, Batzir NA, Orenstein N, Bierhals T, Johannsen J, Uhrova Meszarosova A, Chae JH, Seeman P, Woidy M, Fang F, Kubisch C, Kindler S, Denecke J. | 12/18/2021 |
| Increased expression of KPNA3 was observed in colorectal cancer (CRC) along with that of DLEU1 and associated with lower survival rate and poorer prognosis. Its expression is promoted by DLEU1 which recruits SMARCA1 in CRC. | LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3.
Liu T, Han Z, Li H, Zhu Y, Sun Z, Zhu A., Free PMC Article | 03/23/2019 |
| Studied the role of KPNA3 (karyopherin subunit alpha 3) in nuclear transport of ataxin-3 in spinocerebellar ataxia type 3. | Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.
Sowa AS, Martin E, Martins IM, Schmidt J, Depping R, Weber JJ, Rother F, Hartmann E, Bader M, Riess O, Tricoire H, Schmidt T., Free PMC Article | 08/4/2018 |
| These results suggest that the Japanese encephalitis virus NS5 inhibits the induction of type I interferon by targeting KPNA3 and KPNA4. | Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB.
Ye J, Chen Z, Li Y, Zhao Z, He W, Zohaib A, Song Y, Deng C, Zhang B, Chen H, Cao S., Free PMC Article | 05/20/2017 |
| Karyopherin alpha 3 and karyopherin alpha 4 proteins mediate the nuclear import of methyl-CpG binding protein 2. | Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.
Baker SA, Lombardi LM, Zoghbi HY., Free PMC Article | 12/5/2015 |
| SNP rs2273816 is significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level | KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence.
Morris CP, Baune BT, Domschke K, Arolt V, Swagell CD, Hughes IP, Lawford BR, McD Young R, Voisey J., Free PMC Article | 06/15/2013 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.
Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y, Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y. | 03/13/2008 |
| The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size. | The KPNA3 gene may be a susceptibility candidate for schizophrenia.
Wei J, Hemmings GP. | 01/21/2010 |
| The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia. | A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.
Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y, Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y. | 01/21/2010 |