| Age-related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis. | Age-related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis.
Cheng Q, Chen M, Liu M, Wang F, Chen X, Sun W, Du Y, Wu H. | 02/7/2024 |
| The lncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging. | The lncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging.
Wang Y, Li Y, Li Y, Cui Y, Zhang Y, Shi W, Wang J, Wu X, Liang R, Wang X, Zheng A, Yu Y, Xiong Y. | 06/22/2023 |
| Paracrine Effects of Renal Proximal Tubular Epithelial Cells on Podocyte Injury under Hypoxic Conditions Are Mediated by Arginase-II and TGF-beta1. | Paracrine Effects of Renal Proximal Tubular Epithelial Cells on Podocyte Injury under Hypoxic Conditions Are Mediated by Arginase-II and TGF-β1.
Ma Y, Potenza DM, Ajalbert G, Brenna A, Zhu C, Ming XF, Yang Z., Free PMC Article | 03/17/2023 |
| Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma. | Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma.
Yu Y, Ren Y, Wang C, Li Z, Niu F, Li Z, Ye Q, Wang J, Yan Y, Liu P, Qian L, Xiong Y., Free PMC Article | 01/14/2023 |
| Characterisation of the immune microenvironment of primary breast cancer and brain metastasis reveals depleted T-cell response associated to ARG2 expression. | Characterisation of the immune microenvironment of primary breast cancer and brain metastasis reveals depleted T-cell response associated to ARG2 expression.
Giannoudis A, Varešlija D, Sharma V, Zakaria R, Platt-Higgins A, Rudland PS, Jenkinson MD, Young LS, Palmieri C., Free PMC Article | 01/7/2023 |
| Role of Arginase-II in Podocyte Injury under Hypoxic Conditions. | Role of Arginase-II in Podocyte Injury under Hypoxic Conditions.
Ren Z, Potenza DM, Ma Y, Ajalbert G, Hoogewijs D, Ming XF, Yang Z., Free PMC Article | 10/8/2022 |
| ARG2 single-nucleotide polymorphism rs3742879 affects plasma arginase 2 levels, nitric oxide formation and antihypertensive therapy response in preeclampsia. | ARG2 single-nucleotide polymorphism rs3742879 affects plasma arginase 2 levels, nitric oxide formation and antihypertensive therapy response in preeclampsia.
Luizon MR, Pinto-Souza CC, Coeli-Lacchini F, Lacchini R, Cavalli RC, Sandrim VC. | 09/3/2022 |
| Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation. | Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation.
Chen B, Jin Y, Pool CM, Liu Y, Nelin LD., Free PMC Article | 06/18/2022 |
| Identification and Validation of a Prognostic Model Based on Three MVI-Related Genes in Hepatocellular Carcinoma. | Identification and Validation of a Prognostic Model Based on Three MVI-Related Genes in Hepatocellular Carcinoma.
Tang Y, Xu L, Ren Y, Li Y, Yuan F, Cao M, Zhang Y, Deng M, Yao Z., Free PMC Article | 04/2/2022 |
| High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies. | High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies.
Contreras-Duarte S, Cantin C, Farias M, Leiva A. | 01/1/2022 |
| Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes. | Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes.
Marselli L, Bosi E, De Luca C, Del Guerra S, Tesi M, Suleiman M, Marchetti P., Free PMC Article | 12/18/2021 |
| Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability. | Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability.
Oliveira-Paula GH, Coeli-Lacchini FB, Ferezin LP, Ferreira GC, Pinheiro LC, Paula-Garcia WN, Garcia LV, Tanus-Santos JE, Lacchini R. | 11/22/2021 |
| Effects of arginase genetic polymorphisms on nitric oxide formation in healthy pregnancy and in preeclampsia. | Effects of arginase genetic polymorphisms on nitric oxide formation in healthy pregnancy and in preeclampsia.
Pinto-Souza CC, Coeli-Lacchini F, Luizon MR, Cavalli RC, Lacchini R, Sandrim VC. | 10/16/2021 |
| Single Nucleotide Polymorphisms in the Arginase 1 and 2 Genes Are Differentially Associated with Circulating l-Arginine Concentration in Unsupplemented and l-Arginine-Supplemented Adults. | Single Nucleotide Polymorphisms in the Arginase 1 and 2 Genes Are Differentially Associated with Circulating l-Arginine Concentration in Unsupplemented and l-Arginine-Supplemented Adults.
Hannemann J, Rendant-Gantzberg L, Zummack J, Hillig J, Eilermann I, Böger R. | 09/4/2021 |
| Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action. | Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Austin M, Burschowsky D, Chan DTY, Jenkinson L, Haynes S, Diamandakis A, Seewooruthun C, Addyman A, Fiedler S, Ryman S, Whitehouse J, Slater LH, Hadjinicolaou AV, Gileadi U, Gowans E, Shibata Y, Barnard M, Kaserer T, Sharma P, Luheshi NM, Wilkinson RW, Vaughan TJ, Holt SV, Cerundolo V, Carr MD, Groves MAT., Free PMC Article | 07/10/2021 |
| Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans. | Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans.
Tang R, Wang X, Zhou J, Zhang F, Zhao S, Gan Q, Zhao L, Wang F, Zhang Q, Zhang J, Wang G, Yang C. | 06/5/2021 |
| Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes. | Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes.
Zaric BL, Radovanovic JN, Gluvic Z, Stewart AJ, Essack M, Motwalli O, Gojobori T, Isenovic ER., Free PMC Article | 05/1/2021 |
| Estimation of varicocele associated human ARG2 and NOS1 proteins and computational analysis on the effect of its nsSNPs. | Estimation of varicocele associated human ARG2 and NOS1 proteins and computational analysis on the effect of its nsSNPs.
Karthikeyan V, Vickram AS, Manian R. | 04/13/2021 |
| Arginase-II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling. | Arginase-II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling.
Yu Y, Ladeiras D, Xiong Y, Boligan KF, Liang X, von Gunten S, Hunger RE, Ming XF, Yang Z. | 04/3/2021 |
| Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity. | Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity.
Érsek B, Silló P, Cakir U, Molnár V, Bencsik A, Mayer B, Mezey E, Kárpáti S, Pós Z, Németh K., Free PMC Article | 02/27/2021 |
| Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective. | Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective.
S Clemente G, van Waarde A, F Antunes I, Dömling A, H Elsinga P., Free PMC Article | 02/20/2021 |
| p32-Dependent p38 MAPK Activation by Arginase II Downregulation Contributes to Endothelial Nitric Oxide Synthase Activation in HUVECs. | p32-Dependent p38 MAPK Activation by Arginase II Downregulation Contributes to Endothelial Nitric Oxide Synthase Activation in HUVECs.
Koo BH, Won MH, Kim YM, Ryoo S., Free PMC Article | 02/13/2021 |
| Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. | Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.
Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD., Free PMC Article | 10/24/2020 |
| the present study showed that a higher ARG2 level at birth was associated with statistically significant increased odds of developing ALL later in childhood. | Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology.
Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL., Free PMC Article | 07/18/2020 |
| Arginase II activity-dependent production of spermine augments Ca(2+) transition from the cytosol to the mitochondria in a mitochondrial p32 protein -dependent manner and regulates CaMKII-dependent constriction in vascular smooth muscle cells. | Arginase II activity regulates cytosolic Ca(2+) level in a p32-dependent manner that contributes to Ca(2+)-dependent vasoconstriction in native low-density lipoprotein-stimulated vascular smooth muscle cells.
Koo BH, Hong D, Hong HD, Lim HK, Hoe KL, Won MH, Kim YM, Berkowitz DE, Ryoo S., Free PMC Article | 06/27/2020 |