| Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif containing ciliary targeting sequence. | Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif containing ciliary targeting sequence.
Mahajan D, Madugula V, Lu L., Free PMC Article | 06/1/2023 |
| Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein. | Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.
Pörschke M, Rodríguez-González I, Parfentev I, Urlaub H, Kehlenbach RH., Free PMC Article | 03/31/2023 |
| A minimal construct of nuclear-import receptor Karyopherin-beta2 defines the regions critical for chaperone and disaggregation activity. | A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity.
Fare CM, Rhine K, Lam A, Myong S, Shorter J., Free PMC Article | 03/2/2023 |
| Tumor suppressor BAP1 nuclear import is governed by transportin-1. | Tumor suppressor BAP1 nuclear import is governed by transportin-1.
Yang TJ, Li TN, Huang RS, Pan MY, Lin SY, Lin S, Wu KP, Wang LH, Hsu SD., Free PMC Article | 04/30/2022 |
| Mechanism of karyopherin-beta2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X). | Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).
Gonzalez A, Mannen T, Çağatay T, Fujiwara A, Matsumura H, Niesman AB, Brautigam CA, Chook YM, Yoshizawa T., Free PMC Article | 01/1/2022 |
| TNPO1-mediated nuclear import of ARID1B promotes tumor growth in ARID1A-deficient gynecologic cancer. | TNPO1-mediated nuclear import of ARID1B promotes tumor growth in ARID1A-deficient gynecologic cancer.
Yang B, Chen J, Li X, Zhang X, Hu L, Jiang S, Zhang Z, Teng Y. | 12/25/2021 |
| TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer. | TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer.
Yang B, Chen J, Teng Y., Free PMC Article | 12/4/2021 |
| C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers. | C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers.
Nanaura H, Kawamukai H, Fujiwara A, Uehara T, Aiba Y, Nakanishi M, Shiota T, Hibino M, Wiriyasermkul P, Kikuchi S, Nagata R, Matsubayashi M, Shinkai Y, Niwa T, Mannen T, Morikawa N, Iguchi N, Kiriyama T, Morishima K, Inoue R, Sugiyama M, Oda T, Kodera N, Toma-Fukai S, Sato M, Taguchi H, Nagamori S, Shoji O, Ishimori K, Matsumura H, Sugie K, Saio T, Yoshizawa T, Mori E., Free PMC Article | 10/9/2021 |
| Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS. | Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS.
Arenas A, Chen J, Kuang L, Barnett KR, Kasarskis EJ, Gal J, Zhu H., Free PMC Article | 08/28/2021 |
| HIV-1 resists MxB inhibition of viral Rev protein. | HIV-1 resists MxB inhibition of viral Rev protein.
Wang Z, Chai K, Liu Q, Yi DR, Pan Q, Huang Y, Tan J, Qiao W, Guo F, Cen S, Liang C., Free PMC Article | 04/24/2021 |
| The Renpenning syndrome-associated protein PQBP1 facilitates the nuclear import of splicing factor TXNL4A through the karyopherin beta2 receptor. | The Renpenning syndrome-associated protein PQBP1 facilitates the nuclear import of splicing factor TXNL4A through the karyopherin β2 receptor.
Liu X, Dou LX, Han J, Zhang ZC., Free PMC Article | 12/12/2020 |
| Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import. | Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import.
Carlon-Andres I, Lagadec F, Pied N, Rayne F, Lafon ME, Kehlenbach RH, Wodrich H., Free PMC Article | 10/31/2020 |
| Study provides evidence that TRN-1 mediates the timely release of the HIV-1 genome from the capsid protein shell and efficient viral nuclear import. | Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating.
Fernandez J, Machado AK, Lyonnais S, Chamontin C, Gärtner K, Léger T, Henriquet C, Garcia C, Portilho DM, Pugnière M, Chaloin L, Muriaux D, Yamauchi Y, Blaise M, Nisole S, Arhel NJ. | 02/8/2020 |
| Transportin 1, a member of the importin-beta family proteins, binds to a PY-NLS(2) sequence motif close to the amino terminus of matrix protein (M1) exposed during acid priming of the viral core. | Influenza virus uses transportin 1 for vRNP debundling during cell entry.
Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, Kutay U, Helenius A, Yamauchi Y. | 08/3/2019 |
| high-affinity binding of karyopherin-beta2 to the FUS C-terminal proline-tyrosine nuclear localization signal tethers the proteins together, allowing multiple, distributed weak intermolecular contacts to disrupt FUS self-association, blocking liquid-liquid phase separation | Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Yoshizawa T, Ali R, Jiou J, Fung HYJ, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat M, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK, Chook YM., Free PMC Article | 02/16/2019 |
| TNPO1-mediated nuclear import may constitute a novel input pathway of how cellular redox state signals to the clock, since redox stress increases binding of TNPO1 to PER1 and decreases its nuclear localization. TNPO1 is one of the novel players essential for normal circadian periods and potentially for redox regulation of the clock. | The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization.
Korge S, Maier B, Brüning F, Ehrhardt L, Korte T, Mann M, Herrmann A, Robles MS, Kramer A., Free PMC Article | 06/23/2018 |
| A molecular docking and dynamics study concluded that R521C and R521H mutations in FUS result in weak binding with Karyopherin-beta2 leading to amyotrophic lateral sclerosis. | R521C and R521H mutations in FUS result in weak binding with Karyopherinβ2 leading to Amyotrophic lateral sclerosis: a molecular docking and dynamics study.
Swetha RG, Ramaiah S, Anbarasu A. | 03/31/2018 |
| Data suggest that micoRNA-128 targets the 3prime-untranslated region of nuclear import factor transportin 1 (TNPO1) mRNA. | MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1.
Idica A, Sevrioukov EA, Zisoulis DG, Hamdorf M, Daugaard I, Kadandale P, Pedersen IM., Free PMC Article | 01/27/2018 |
| the TNPO1-Rab8-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia. | A ternary complex comprising transportin1, Rab8 and the ciliary targeting signal directs proteins to ciliary membranes.
Madugula V, Lu L., Free PMC Article | 08/5/2017 |
| Together, these results indicate that transportin-1 mediates YB-1 nuclear translocation. | Transportin-1-dependent YB-1 nuclear import.
Mordovkina DA, Kim ER, Buldakov IA, Sorokin AV, Eliseeva IA, Lyabin DN, Ovchinnikov LP. | 06/3/2017 |
| findings suggest that a new player, i.e., O-GlcNAcylation, regulates hnRNP A1 translocation and interaction with Trn1, possibly affecting its function | The effect of O-GlcNAcylation on hnRNP A1 translocation and interaction with transportin1.
Roth S, Khalaila I. | 06/3/2017 |
| Importins, Impbeta, Kapbeta2, Imp4, Imp5, Imp7, Imp9, and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly. | Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.
Soniat M, Cağatay T, Chook YM., Free PMC Article | 05/20/2017 |
| Results show that Karyopherin-b2 binds to the N-terminal tail of histone H3 with high affinity even though H3 lacks a recognizable proline-tyrosine nuclear localization signal (PY-NLS). | Karyopherin-β2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.
Soniat M, Chook YM., Free PMC Article | 05/6/2017 |
| FGF2 nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase in human glioblastoma cells | Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells.
Wang F, Yang L, Shi L, Li Q, Zhang G, Wu J, Zheng J, Jiao B., Free PMC Article | 06/11/2016 |
| Kapbeta2 interacts with ULK2 through ULK2's putative PY-NLS motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity. | ULK2 Ser 1027 Phosphorylation by PKA Regulates Its Nuclear Localization Occurring through Karyopherin Beta 2 Recognition of a PY-NLS Motif.
Shin SH, Lee EJ, Chun J, Hyun S, Kang SS., Free PMC Article | 03/5/2016 |