| Keratin 6A Is Expressed at the Invasive Front and Enhances the Progression of Colorectal Cancer. | Keratin 6A Is Expressed at the Invasive Front and Enhances the Progression of Colorectal Cancer.
Harada-Kagitani S, Kouchi Y, Shinomiya Y, Kodama M, Ohira G, Matsubara H, Ikeda JI, Kishimoto T. | 08/19/2024 |
| ECM1 and KRT6A are involved in tumor progression and chemoresistance in the effect of dexamethasone on pancreatic cancer. | ECM1 and KRT6A are involved in tumor progression and chemoresistance in the effect of dexamethasone on pancreatic cancer.
Shinomiya Y, Kouchi Y, Harada-Kagitani S, Ishige T, Takano S, Ohtsuka M, Ikeda JI, Kishimoto T., Free PMC Article | 07/8/2024 |
| KRT6A Inhibits IL-1beta-Mediated Pyroptosis of Keratinocytes via Blocking IL-17 Signaling. | KRT6A Inhibits IL-1β-Mediated Pyroptosis of Keratinocytes via Blocking IL-17 Signaling.
Li Y, Wu Q. | 03/21/2024 |
| The expression pattern of cytokeratin 6a in epithelial cells of different origin in dermo-epidermal skin substitutes in vivo. | The expression pattern of cytokeratin 6a in epithelial cells of different origin in dermo-epidermal skin substitutes in vivo.
Michalak-Micka K, Tenini C, Böttcher-Haberzeth S, Mazzone L, Pontiggia L, Klar AS, Moehrlen U, Biedermann T. | 02/7/2024 |
| Cytokeratin 5/6 expression in pT1 bladder cancer predicts intravesical recurrence in patients treated with bacillus Calmette-Guerin instillation. | Cytokeratin 5/6 expression in pT1 bladder cancer predicts intravesical recurrence in patients treated with bacillus Calmette-Guérin instillation.
Yamamoto Y, Takahara T, Ohashi A, Taniguchi N, Ito T, Sassa N, Tsuzuki T. | 10/1/2022 |
| KRT6A expedites bladder cancer progression, regulated by miR-31-5p. | KRT6A expedites bladder cancer progression, regulated by miR-31-5p.
Chen Y, Ji S, Ying J, Sun Y, Liu J, Yin G., Free PMC Article | 07/16/2022 |
| A KRT6A mutation p.Ile462Asn in a Chinese family with pachyonychia congenita, and identification of maternal mosaicism: a case report. | A KRT6A mutation p.Ile462Asn in a Chinese family with pachyonychia congenita, and identification of maternal mosaicism: a case report.
Li Y, Wang Y, Ming Y, Chaolan P, Jia Z, Cheng N, Qiaoyu C, Li M, Tianyi X., Free PMC Article | 03/5/2022 |
| Keratin 6a mutations lead to impaired mitochondrial quality control. | Keratin 6a mutations lead to impaired mitochondrial quality control.
Lehmann SM, Leube RE, Schwarz N. | 06/12/2021 |
| Comprehensive Gene Expression Analyses of Immunohistochemically Defined Subgroups of Muscle-Invasive Urinary Bladder Urothelial Carcinoma. | Comprehensive Gene Expression Analyses of Immunohistochemically Defined Subgroups of Muscle-Invasive Urinary Bladder Urothelial Carcinoma.
Kim B, Jang I, Kim K, Jung M, Lee C, Park JH, Kim YA, Moon KC., Free PMC Article | 04/13/2021 |
| Anti-tumour effects of Keratin 6A in lung adenocarcinoma. | Anti-tumour effects of Keratin 6A in lung adenocarcinoma.
Xiao J, Kuang X, Dai L, Zhang L, He B. | 04/3/2021 |
| Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression. | Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression.
Jung M, Jang I, Kim K, Moon KC., Free PMC Article | 02/27/2021 |
| KRT6A Promotes EMT and Cancer Stem Cell Transformation in Lung Adenocarcinoma. | KRT6A Promotes EMT and Cancer Stem Cell Transformation in Lung Adenocarcinoma.
Yang B, Zhang W, Zhang M, Wang X, Peng S, Zhang R., Free PMC Article | 01/9/2021 |
| KRT6A silencing suppressed cell viability, invasion and metastasis of NPC cells via beta-catenin/TCF pathway. | Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade.
Chen C, Shan H., Free PMC Article | 08/3/2019 |
| Manipulating K6a phosphorylation or ubiquitin-proteasome system (UPS) activity may provide opportunities to harness the innate immunity of epithelia against infection. | Keratin 6a reorganization for ubiquitin-proteasomal processing is a direct antimicrobial response.
Chan JKL, Yuen D, Too PH, Sun Y, Willard B, Man D, Tam C., Free PMC Article | 12/22/2018 |
| Cytokeratin 5/6 and CK8/18 immunohistochemistry on 150 cases of triple negative breast cancers was performed and association with various clinicopathological features was evaluated. | Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population.
Hashmi AA, Naz S, Hashmi SK, Hussain ZF, Irfan M, Bakar SMA, Faridi N, Khan A, Edhi MM., Free PMC Article | 10/13/2018 |
| Data indicate that cytokeratin 5/6 (CK5/6) is an independent prognostic biomarker in urothelial carcinoma and therefore can be used in the prognostic stratification of the patients with bladder cancer. | Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis.
Hashmi AA, Hussain ZF, Irfan M, Edhi MM, Kanwal S, Faridi N, Khan A., Free PMC Article | 09/29/2018 |
| Several missense polymorphisms in KRT6A, KRT6B and KRT6C that lead to a higher risk for dental caries. | Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.
Duverger O, Carlson JC, Karacz CM, Schwartz ME, Cross MA, Marazita ML, Shaffer JR, Morasso MI., Free PMC Article | 06/23/2018 |
| KRT6A genetic mutation is associate with the development of Pachyonychia Congenita in patients in Australia. | Pachyonychia Congenita: A Spectrum of KRT6a Mutations in Australian Patients.
Forrest CE, Casey G, Mordaunt DA, Thompson EM, Gordon L. | 04/1/2017 |
| we here describe a family with pachyonychia congenita K6a, manifesting atypical symptoms of impaired wound healing and cheilitis. | Impaired wound healing and cheilitis in a Pachyonychia congenita K6a family.
Winge MC, Bradley M, Björck E. | 10/31/2015 |
| Keratin-derived antimicrobial peptides (KDAMPs) and their synthetic analogs exhibit antimicrobial activity against bacterial pathogens. | Cytokeratins mediate epithelial innate defense through their antimicrobial properties.
Tam C, Mun JJ, Evans DJ, Fleiszig SM., Free PMC Article | 10/1/2014 |
| CK5/6, but not c-Met expression, seems to be important in lymphatic metastasis | Cytokeratin 5/6, c-Met expressions, and PTEN loss prognostic indicators in triple-negative breast cancer.
Inanc M, Ozkan M, Karaca H, Berk V, Bozkurt O, Duran AO, Ozaslan E, Akgun H, Tekelioglu F, Elmali F. | 07/26/2014 |
| Genotype-phenotype correlations among PC patients with codon-125 mutation in KRT16 were established, while the phenotypes caused by the IVS8-2A>C mutation in KRT6A need further studies to confirm the rare feature of fissured tongue | Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma.
Du ZF, Xu CM, Zhao Y, Liu WT, Chen XL, Chen CY, Fang H, Ke HP, Zhang XN. | 03/2/2013 |
| Data show that calretinin and CK5/6 were positive in 100 and 64% of mesotheliomas, and 92 and 31% of reactive effusions, respectively, and desmin was negative in all malignant cases and positive in 85% of reactive effusions. | The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.
Hyun TS, Barnes M, Tabatabai ZL. | 02/2/2013 |
| We observed a higher likelihood of oral leukokeratosis in individuals harboring KRT6A mutations. | A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.
Eliason MJ, Leachman SA, Feng BJ, Schwartz ME, Hansen CD. | 12/8/2012 |
| Phenotypic differences exist between KRT6A and KRT16 mutations support adoption of a new classification system. | Pachyonychia congenita patients with mutations in KRT6A have more extensive disease compared with patients who have mutations in KRT16.
Spaunhurst KM, Hogendorf AM, Smith FJ, Lingala B, Schwartz ME, Cywinska-Bernas A, Zeman KJ, Tang JY. | 09/22/2012 |