| Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes. | Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes.
Yawut N, Kaowinn S, Cho IR, Budluang P, Kim S, Kim S, Youn SE, Koh SS, Chung YH., Free PMC Article | 03/19/2022 |
| Knockdown of CENPW Inhibits Hepatocellular Carcinoma Progression by Inactivating E2F Signaling. | Knockdown of CENPW Inhibits Hepatocellular Carcinoma Progression by Inactivating E2F Signaling.
Zhou Y, Chai H, Guo L, Dai Z, Lai J, Duan J, Liu Y, Ding Q., Free PMC Article | 12/4/2021 |
| Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis. | Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis.
Aygün N, Elwell AL, Liang D, Lafferty MJ, Cheek KE, Courtney KP, Mory J, Hadden-Ford E, Krupa O, de la Torre-Ubieta L, Geschwind DH, Love MI, Stein JL., Free PMC Article | 09/18/2021 |
| The novel CUG2 oncogene promotes cellular transformation and stemness, mediated by nuclear NPM1 protein and TGF-beta signaling. | Cancer upregulated gene 2 (CUG2), a novel oncogene, promotes stemness-like properties via the NPM1-TGF-β signaling axis.
Kaowinn S, Seo EJ, Heo W, Bae JH, Park EJ, Lee S, Kim YJ, Koh SS, Jang IH, Shin DH, Chung YH. | 07/25/2020 |
| CUG2 enhances expression of YAP1 protein. Akt and MAPK kinases are involved in the increase of YAP1 protein expression under overexpression of CUG2. | Cancer upregulated gene (CUG)2 elevates YAP1 expression, leading to enhancement of epithelial-mesenchymal transition in human lung cancer cells.
Kaowinn S, Yawut N, Koh SS, Chung YH. | 12/14/2019 |
| Study provide new evidence to suggest that CUG2 overexpression contributes to tumor formation through NEK2/beta-catenin signaling by enhancing the phosphorylation of betacatenin at Ser33/Ser37 by activating NEK2, thus stabilizing betacatenin. | CGK062, a small chemical molecule, inhibits cancer upregulated gene 2‑induced oncogenesis through NEK2 and β‑catenin.
Kaowinn S, Oh S, Moon J, Yoo AY, Kang HY, Lee MR, Kim JE, Hwang DY, Youn SE, Koh SS, Chung YH., Free PMC Article | 08/31/2019 |
| CENP-W showed a higher affinity toward the beta-TrCP1 b isoform. | Two major alternative splice variants of beta-TrCP1 interact with CENP-W with different binding preferences.
Cheon Y, Lee S. | 04/6/2019 |
| we suggest that STAT1HDAC4 signaling induces malignant tumor features such as EMT and sphere formation in CUG2overexpressing cancer cells. | STAT1‑HDAC4 signaling induces epithelial‑mesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2.
Kaowinn S, Kaewpiboon C, Koh SS, Krämer OH, Chung YH., Free PMC Article | 12/29/2018 |
| Report provides evidence that CUG2 induces the EMT in human lung cancer cells via enhancement of TGF-beta signaling and that that TGF-beta signaling is a potential target for CUG2-mediated oncogenesis. | Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGF-β signaling.
Kaowinn S, Kim J, Lee J, Shin DH, Kang CD, Kim DK, Lee S, Kang MK, Koh SS, Kim SJ, Chung YH., Free PMC Article | 02/24/2018 |
| It has been proposed that CENP-W may function as a booster of beta-TrCP1 nuclear import to increase the oncogenicity of beta-TrCP1. | Centromere protein W interacts with beta-transducin repeat-containing protein 1 and modulates its subcellular localization.
Cheon Y, Jeon S, Lee S. | 05/20/2017 |
| FACT chaperone stabilizes the soluble CENP-T/-W complex in the cell and promotes dynamics of exchange, enabling CENP-T/-W deposition at centromeres. | The CENP-T/-W complex is a binding partner of the histone chaperone FACT.
Prendergast L, Müller S, Liu Y, Huang H, Dingli F, Loew D, Vassias I, Patel DJ, Sullivan KF, Almouzni G., Free PMC Article | 04/29/2017 |
| CENP-W interacts with hnRNPU and may contribute to kinetochore-microtubule attachment in mitotic cells. | Centromere Protein (CENP)-W Interacts with Heterogeneous Nuclear Ribonucleoprotein (hnRNP) U and May Contribute to Kinetochore-Microtubule Attachment in Mitotic Cells.
Chun Y, Kim R, Lee S., Free PMC Article | 07/30/2016 |
| CENP-W is a novel kinetochore component that may be involved in the EZH2-mediated silencing machinery. | A new kinetochore component CENP-W interacts with the polycomb-group protein EZH2 to promote gene silencing.
Koh W, Park B, Lee S. | 10/3/2015 |
| We propose that CENP-W, by influencing proper kinetochore assembly, particularly microtubule docking sites, can confer spindle pole resistance to traction forces exerted by motor proteins during chromosome congression | CENP-W plays a role in maintaining bipolar spindle structure.
Kaczmarczyk A, Sullivan KF., Free PMC Article | 07/4/2015 |
| CUG2-mediated antiviral activity can be reduced by ISG15 deficiency in A549 cells, which eventually enhances sensitivity of the cells to vesicular stomatitis virus infection. | Suppression of autophagic genes sensitizes CUG2-overexpressing A549 human lung cancer cells to oncolytic vesicular stomatitis virus-induced apoptosis.
Malilas W, Koh SS, Lee S, Srisuttee R, Cho IR, Moon J, Kaowinn S, Johnston RN, Chung YH. | 11/29/2014 |
| our results suggest that CUG2 enhances metastasis and drug resistance through STAT1 activation, which eventually contributes to tumor progression | Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation.
Malilas W, Koh SS, Kim S, Srisuttee R, Cho IR, Moon J, Yoo HS, Oh S, Johnston RN, Chung YH. | 04/12/2014 |
| CSN5 regulates the stability of the inner kinetochore components CENP-T and CENP-W, providing the first direct link between CSN5 and the mitotic apparatus, highlighting the role of CSN5 as a multifunctional cell cycle regulator. | CSN5/JAB1 interacts with the centromeric components CENP-T and CENP-W and regulates their proteasome-mediated degradation.
Chun Y, Lee M, Park B, Lee S., Free PMC Article | 11/30/2013 |
| we propose that VSV treatment combined with the selective regulation of genes such as STAT1 and OASL2 will improve therapeutic outcomes for CUG2-overexpressing tumors. | Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling.
Malilas W, Koh SS, Srisuttee R, Boonying W, Cho IR, Jeong CS, Johnston RN, Chung YH. | 09/7/2013 |
| Single nucleotide polymorphism in CENPW is associated with the length of reproductive lifespan. | Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.
Chen CT, Fernández-Rhodes L, Brzyski RG, Carlson CS, Chen Z, Heiss G, North KE, Woods NF, Rajkovic A, Kooperberg C, Franceschini N., Free PMC Article | 08/11/2012 |
| B23 may function in the assembly of the kinetochore complex by interacting with CENP-W during interphase | New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein.
Chun Y, Park B, Koh W, Lee S, Cheon Y, Kim R, Che L, Lee S., Free PMC Article | 02/25/2012 |
| The CENP-T/W complex assembles through a dynamic exchange mechanism in late S-phase and G2, is required for mitosis in each cell cycle and does not persist across cell generations. | Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state.
Prendergast L, van Vuuren C, Kaczmarczyk A, Doering V, Hellwig D, Quinn N, Hoischen C, Diekmann S, Sullivan KF., Free PMC Article | 10/29/2011 |
| Sp1 together with Sp3 may function as the main regulator of the basal and serum-induced transcription of CENP-W. | Sp1 and Sp3 mediate basal and serum-induced expression of human CENP-W.
Kim H, Lee S, Park B, Che L, Lee S. | 01/15/2011 |
| Overexpression of CUG2 induces apoptosis in SKOV-3 cells. | Cancer-upregulated gene 2 (CUG2) overexpression induces apoptosis in SKOV-3 cells.
Lee S, Koh W, Kim HT, Kim CH, Lee S. | 01/1/2011 |
| data indicate that activation of p38 MAPK and Ras has critical roles in reoviral replication in CUG2-expressing tumor cells. | CUG2, a novel oncogene confers reoviral replication through Ras and p38 signaling pathway.
Park EH, Park EH, Cho IR, Srisuttee R, Min HJ, Oh MJ, Jeong YJ, Jhun BH, Johnston RN, Lee S, Koh SS, Chung YH. | 08/2/2010 |
| Study demonstrates that CENP-W forms a DNA-binding complex together with the CCAN component CENP-T; this complex directly associates with nucleosomal DNA and with canonical histone H3, but not with CENP-A, in centromeric regions. | CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore.
Hori T, Amano M, Suzuki A, Backer CB, Welburn JP, Dong Y, McEwen BF, Shang WH, Suzuki E, Okawa K, Cheeseman IM, Fukagawa T. | 01/21/2010 |