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    C1QL3 complement C1q like 3 [ Homo sapiens (human) ]

    Gene ID: 389941, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis Protection.

    CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis Protection.
    Du J, Wu J, Zhang Y, Liu Q, Luo X, Huang X, Wang X, Yang F, Hou J., Free PMC Article

    02/7/2024
    CTRP13 alleviates palmitic acid-induced inflammation, oxidative stress, apoptosis and endothelial cell dysfunction in HUVECs.

    CTRP13 alleviates palmitic acid-induced inflammation, oxidative stress, apoptosis and endothelial cell dysfunction in HUVECs.
    Zhu W, Yang G, Chen N, Zhang W, Gao Q, Li T, Yuan N, Jin H.

    01/26/2024
    CTRP13 ablation improves systemic glucose and lipid metabolism.

    CTRP13 ablation improves systemic glucose and lipid metabolism.
    Chen F, Sarver DC, Saqib M, Zhou M, Aja S, Seldin MM, Wong GW., Free PMC Article

    11/30/2023
    Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder

    Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder.
    Erbaş İM, Paketçi A, Turan S, Şişman AR, Demir K, Böber E, Abacı A., Free PMC Article

    06/18/2022
    CTRP13 preserves endothelial function in diabetic mice by regulating GCH1/BH4 axis-dependent eNOS coupling, suggesting the therapeutic potential of CTRP13 against diabetic vasculopathy.

    CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes.
    Wang C, Chao Y, Xu W, Liang M, Deng S, Zhang D, Huang K.

    07/11/2020
    findings define CTRP13 as a novel approach for preventing atherosclerotic plaque formation via modulation of lipid uptake and foam-cell migration

    CTRP13 inhibits atherosclerosis via autophagy-lysosome-dependent degradation of CD36.
    Wang C, Xu W, Liang M, Huang D, Huang K.

    10/5/2019
    BAI3 mediates the inhibitory effects of C1ql3 on insulin secretion from pancreatic beta-cells.

    Complement 1q-like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein-coupled receptor BAI3.
    Gupta R, Nguyen DC, Schaid MD, Lei X, Balamurugan AN, Wong GW, Kim JA, Koltes JE, Kimple ME, Bhatnagar S., Free PMC Article

    06/29/2019
    Study results indicated that decreased adiponectin, CTRP12, and CTRP13 levels, regardless of obesity, could independently predict polycystic ovarian syndrome (PCOS). This finding suggested a novel link between adipokines and PCOS.

    Lower circulating levels of CTRP12 and CTRP13 in polycystic ovarian syndrome: Irrespective of obesity.
    Shanaki M, Moradi N, Fadaei R, Zandieh Z, Shabani P, Vatannejad A., Free PMC Article

    06/8/2019
    CTRP13 is a novel adipokine that is down-regulated in the serum of type 2 diabetics.

    The Circulating Levels of Complement-C1q/TNF-Related Protein 13 (CTRP13) in Patients with Type 2 Diabetes and its Association with Insulin Resistance.
    Afrookhteh A, Emamgholipour S, Alipoor B, Moradi N, Meshkani R, Nasli-Esfahani E, Rahimipour A, Shanaki M.

    12/16/2017
    decreased levels of CTRP3 and especially CTRP13 were associated with increased risk of T2DM and CAD

    Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 Serum Levels with Coronary Artery Disease in Subjects with and without Type 2 Diabetes Mellitus.
    Fadaei R, Moradi N, Baratchian M, Aghajani H, Malek M, Fazaeli AA, Fallah S., Free PMC Article

    07/15/2017
    CTRP13 reduces glucose output in hepatocytes by inhibiting the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase and the cytosolic form of phosphoenolpyruvate carboxykinase.

    Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling.
    Wei Z, Peterson JM, Wong GW., Free PMC Article

    07/2/2011
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