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    LAMB3 laminin subunit beta 3 [ Homo sapiens (human) ]

    Gene ID: 3914, updated on 6-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway.

    MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway.
    Ma D, Liu S, Liu K, Kong L, Xiao L, Xin Q, Jiang C, Wu J., Free PMC Article

    03/27/2024
    PARP1-stabilised FOXQ1 promotes ovarian cancer progression by activating the LAMB3/WNT/beta-catenin signalling pathway.

    PARP1-stabilised FOXQ1 promotes ovarian cancer progression by activating the LAMB3/WNT/β-catenin signalling pathway.
    Wu J, Wu Y, Chen S, Guo Q, Shao Y, Liu C, Lin K, Wang S, Zhu J, Chen X, Ju X, Xia L, Wu X.

    03/18/2024
    Downregulation of LAMB3 Altered the Carcinogenic Properties of Human Papillomavirus 16-Positive Cervical Cancer Cells.

    Downregulation of LAMB3 Altered the Carcinogenic Properties of Human Papillomavirus 16-Positive Cervical Cancer Cells.
    Wattanathavorn W, Seki M, Suzuki Y, Buranapraditkun S, Kitkumthorn N, Sasivimolrattana T, Bhattarakosol P, Chaiwongkot A., Free PMC Article

    03/14/2024
    LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway.

    LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway.
    Qin X, Zeng B, Sooranna SR, Li M., Free PMC Article

    02/16/2024
    LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.

    LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.
    Liu F, Xu W, Wang Y, Huang Z, Zhu Z, Ou W, Tang W, Fu J, Liu C, Gu Y, Liu Y, Du P.

    02/7/2024
    Perivascular mast cells and expression of vascular endothelial growth factor, laminin-332 and matrix metalloproteinase-9 in human colorectal neoplasms.

    Perivascular mast cells and expression of vascular endothelial growth factor, laminin-332 and matrix metalloproteinase-9 in human colorectal neoplasms.
    Meloti-Fiorio L, Silva-Sinara-Alves I, Rohor-de-Souza F, Grassi-Bautz W, Silva-Souza-Ribeiro F, Pinto-Nogueira-da-Gama L, Nogueira-da-Gama-de-Souza L.

    01/12/2024
    Tumor-derived extracellular vesicles delivering TNF-alpha promotes colorectal cancer metastasis via the NF-kB/LAMB3/AKT axis by targeting SNAP23.

    Tumor-derived extracellular vesicles delivering TNF-α promotes colorectal cancer metastasis via the NF-kB/LAMB3/AKT axis by targeting SNAP23.
    Xie BW, Guan B, Chen W, Zhou M, Gu Q, Liu Y, Yan D.

    05/20/2023
    A novel splice-site variant of the LAMB3 gene is associated with junctional epidermolysis bullosa.

    A novel splice-site variant of the LAMB3 gene is associated with junctional epidermolysis bullosa.
    Liang B, Meng D, Cao Y, Zhang D, Zhou J, Chen M, Chen G, Huang H.

    03/3/2023
    Novel LAMB3 variants in two Asian patients and an overview of LAMB3 variants associated with generalized intermediate junctional epidermolysis bullosa.

    Novel LAMB3 variants in two Asian patients and an overview of LAMB3 variants associated with generalized intermediate junctional epidermolysis bullosa.
    Tan EC, Diana IA, Wei H, Gondokaryono SP, Dwiyana RF, Yogya Y, Rahardja JI, Koh MJ.

    01/28/2023
    Endometrial laminin subunit beta-3 expression associates with reproductive outcome in patients with repeated implantation failure.

    Endometrial laminin subunit beta-3 expression associates with reproductive outcome in patients with repeated implantation failure.
    Li T, Greenblatt EM, Shin ME, Brown TJ, Chan C., Free PMC Article

    01/1/2022
    ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis.

    ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis.
    Islam S, Kitagawa T, Baron B, Abiko Y, Chiba I, Kuramitsu Y., Free PMC Article

    11/13/2021
    Complexity of Transcriptional and Translational Interference of Laminin-332 Subunits in Junctional Epidermolysis Bullosa with LAMB3 Mutations.

    Complexity of Transcriptional and Translational Interference of Laminin-332 Subunits in Junctional Epidermolysis Bullosa with LAMB3 Mutations.
    Hou PC, Natsuga K, Tu WT, Huang HY, Chen B, Chen LY, Chen WR, Hong YK, Tang YA, Lee JY, Chen PC, Sun HS, McGrath JA, Hsu CK., Free PMC Article

    09/25/2021
    Laminin332 mediates proliferation, apoptosis, invasion, migration and epithelialtomesenchymal transition in pancreatic ductal adenocarcinoma.

    Laminin‑332 mediates proliferation, apoptosis, invasion, migration and epithelial‑to‑mesenchymal transition in pancreatic ductal adenocarcinoma.
    Huang C, Chen J., Free PMC Article

    05/1/2021
    Laminin-332 expression in oral lichen planus: Preliminary results of a cross-sectional study.

    Laminin-332 expression in oral lichen planus: Preliminary results of a cross-sectional study.
    Akama MSK, Teixeira LR, Innocentini LMAR, Gallo CB, Pinheiro TN, Ribeiro-Silva A, Motta ACF.

    05/1/2021
    LncRNA DDX11-AS1 Promotes Bladder Cancer Occurrence Via Protecting LAMB3 from Downregulation by Sponging miR-2355-5p.

    LncRNA DDX11-AS1 Promotes Bladder Cancer Occurrence Via Protecting LAMB3 from Downregulation by Sponging miR-2355-5p.
    Chen D, Chen J, Gao J, Zhang Y, Ma Y, Wei W, Wei Y.

    01/23/2021
    Tissue substructure-specific deposition of the beta3-containing laminin-332 in the biliary epithelium of human and mouse livers.

    Tissue substructure-specific deposition of the β3-containing laminin-332 in the biliary epithelium of human and mouse livers.
    Yamada M, Okada H, Kikkawa Y, Miyajima A, Itoh T.

    10/24/2020
    The laminin-332 and type-XVII collagen were also localized to the intercellular site and critical for contact following.

    The intercellular expression of type-XVII collagen, laminin-332, and integrin-β1 promote contact following during the collective invasion of a cancer cell population.
    Kumagai Y, Nio-Kobayashi J, Ishida-Ishihara S, Tachibana H, Omori R, Enomoto A, Ishihara S, Haga H.

    07/25/2020
    2 novel C-terminal variants in LAMB3 causing autosomal dominant amelogenesis imperfecta in the absence of skin or mucous membrane abnormalities

    Phenotype and Variant Spectrum in the LAMB3 Form of Amelogenesis Imperfecta.
    Smith CEL, Poulter JA, Brookes SJ, Murillo G, Silva S, Brown CJ, Patel A, Hussain H, Kirkham J, Inglehearn CF, Mighell AJ., Free PMC Article

    07/18/2020
    results showed that LAMB3 could mediate cell cycle arrest and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells and alter the proliferative, invasive, and metastatic behaviors of PDAC by regulating the PI3K/Akt signaling pathway.

    LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway.
    Zhang H, Pan YZ, Cheung M, Cao M, Yu C, Chen L, Zhan L, He ZW, Sun CY., Free PMC Article

    05/23/2020
    MiR-329 inhibits BDC progression through translational repression of LAMB3.

    microRNA-329 suppresses epithelial-to-mesenchymal transition and lymph node metastasis in bile duct cancer by inhibiting laminin subunit beta 3.
    Liao CH, Liu Y, Wu YF, Zhu SW, Cai RY, Zhou L, Yin XM.

    05/23/2020
    Mutations in LAMB3 and FAM20A were found in 3 Turkish families with Amelogenesis imperfecta

    Candidate gene sequencing reveals mutations causing hypoplastic amelogenesis imperfecta.
    Kim YJ, Seymen F, Kang J, Koruyucu M, Tuloglu N, Bayrak S, Tuna EB, Lee ZH, Shin TJ, Hyun HK, Kim YJ, Lee SH, Hu J, Simmer J, Kim JW., Free PMC Article

    12/21/2019
    LM332 expression in breast carcinoma is associated with tumor cell motility and decreased survival.

    Laminin 332 expression and prognosis in breast cancer.
    Carpenter PM, Ziogas A, Markham EM, Cantillep AS, Yan R, Anton-Culver H., Free PMC Article

    10/26/2019
    High expression of LAMB3 is associated with papillary thyroid cancer invasion.

    LAMB3 mediates metastatic tumor behavior in papillary thyroid cancer by regulating c-MET/Akt signals.
    Jung SN, Lim HS, Liu L, Chang JW, Lim YC, Rha KS, Koo BS., Free PMC Article

    09/21/2019
    This study provides evidence for efficient CRISPR/Cas9-mediated in situ restoration of LAMB3 expression, paving the way for ex vivo clinical application of this strategy to laminin 332 deficiency.

    CRISPR/Cas9-Mediated In Situ Correction of LAMB3 Gene in Keratinocytes Derived from a Junctional Epidermolysis Bullosa Patient.
    Benati D, Miselli F, Cocchiarella F, Patrizi C, Carretero M, Baldassarri S, Ammendola V, Has C, Colloca S, Del Rio M, Larcher F, Recchia A., Free PMC Article

    09/7/2019
    Novel compound heterozygous and homozygous variants of LAMB3 gene underlie non-Herlitz junctional epidermolysis bullosa in two paternal half-brothers from Saudi Arabia.

    Novel compound heterozygous and homozygous variants of laminin subunit β3 gene underlie non-Herlitz junctional epidermolysis bullosa in two paternal half-brothers from Saudi Arabia.
    Al-Zahrani HS, Al-Tala S, Mohamoud HSA, Al-Shehri BA, Al-Fadhel S, Al-Qurashi A, Al-Bishri A, Al-Aama JY, Kang C, Betz RC, Jelani M.

    08/31/2019
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