| Comparative Analysis of Site-Specific N-glycosylation of LAMP1 from Breast Cancer Tissues. | Comparative Analysis of Site-Specific N-glycosylation of LAMP1 from Breast Cancer Tissues.
Ohashi S, Takakura D, Kobayashi N, Tokuhisa M, Ichikawa Y, Kawasaki N. | 05/2/2024 |
| Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif. | Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif.
Ecard J, Lian YL, Divoux S, Gouveia Z, Vigne E, Perez F, Boncompain G., Free PMC Article | 02/6/2024 |
| Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma. | Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma.
Basbous S, Dif L, Dantzer C, Di-Tommaso S, Dupuy JW, Bioulac-Sage P, Raymond AA, Desdouets C, Saltel F, Moreau V., Free PMC Article | 01/17/2024 |
| Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Zhang J, Zeng W, Han Y, Lee WR, Liou J, Jiang Y., | 07/25/2023 |
| Human LAMP1 accelerates Lassa virus fusion and potently promotes fusion pore dilation upon forcing viral fusion with non-endosomal membrane. | Human LAMP1 accelerates Lassa virus fusion and potently promotes fusion pore dilation upon forcing viral fusion with non-endosomal membrane.
Zhang Y, Carlos de la Torre J, Melikyan GB., Free PMC Article | 09/3/2022 |
| Porcine hemagglutinating encephalomyelitis virus induces atypical autophagy via opposite regulation of expression and nuclear translocation of transcription factor EB. | Porcine hemagglutinating encephalomyelitis virus induces atypical autophagy via opposite regulation of expression and nuclear translocation of transcription factor EB.
Wang Z, Song D, Wang G, Li C, Liu X, Wang X, Li Z, Guan J, Zhao K, He W, Gao F, Lan Y. | 09/25/2021 |
| Mitochondria-lysosome membrane contacts are defective in GDAP1-related Charcot-Marie-Tooth disease. | Mitochondria-lysosome membrane contacts are defective in GDAP1-related Charcot-Marie-Tooth disease.
Cantarero L, Juárez-Escoto E, Civera-Tregón A, Rodríguez-Sanz M, Roldán M, Benítez R, Hoenicka J, Palau F., Free PMC Article | 09/11/2021 |
| Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells. | Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells.
Xu J, Wang Y, Hsu CY, Negri S, Tower RJ, Gao Y, Tian Y, Sono T, Meyers CA, Hardy WR, Chang L, Hu S, Kahn N, Broderick K, Péault B, James AW., Free PMC Article | 02/27/2021 |
| Leishmania aethiopica cell-to-cell spreading involves caspase-3, AkT, and NF-kappaB but not PKC-delta activation and involves uptake of LAMP-1-positive bodies containing parasites. | Leishmania aethiopica cell-to-cell spreading involves caspase-3, AkT, and NF-κB but not PKC-δ activation and involves uptake of LAMP-1-positive bodies containing parasites.
Ranatunga M, Rai R, Richardson SCW, Dyer P, Harbige L, Deacon A, Pecorino L, Getti GTM. | 01/23/2021 |
| Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. | Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer.
Panda PK, Patra S, Naik PP, Praharaj PP, Mukhopadhyay S, Meher BR, Gupta PK, Verma RS, Maiti TK, Bhutia SK. | 12/19/2020 |
| Hyperglycosylated LAMP1 is associated with the neuro-inflammatory phenotype of Niemann-Pick disease, type C. | Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology.
Cawley NX, Sojka C, Cougnoux A, Lyons AT, Nicoli ER, Wassif CA, Porter FD., Free PMC Article | 04/18/2020 |
| we demonstrate that LAMP1 is a direct target in UBL4A-induced tumor suppression and inhibition of autophagy. | UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1.
Chen H, Li L, Hu J, Zhao Z, Ji L, Cheng C, Zhang G, Zhang T, Li Y, Chen H, Pan S, Sun B., Free PMC Article | 12/21/2019 |
| HPbetaCD and HPgammaCD facilitate cholesterol export from the LE/LY compartments via the LAMP-1 protein. | Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1.
Singhal A, Szente L, Hildreth JEK, Song B., Free PMC Article | 11/16/2019 |
| LAMP1 expression is associated with diffuse large B-cell lymphoma. | LAMP1 Overexpression Predicts for Poor Prognosis in Diffuse Large B-cell Lymphoma.
Dang Q, Zhou H, Qian J, Yang L, Huang J, Zhang Y, Shi W. | 10/26/2019 |
| Here the authors used wild-type (WT) and Lamp1 knockout (KO) cells to show that Lamp1 increases the efficiency of, but is not absolutely required for, Lassa virus entry and infection. | Lamp1 Increases the Efficiency of Lassa Virus Infection by Promoting Fusion in Less Acidic Endosomal Compartments.
Hulseberg CE, Fénéant L, Szymańska KM, White JM., Free PMC Article | 01/12/2019 |
| LIN28A inhibits lysosomeassociated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells. | LIN28A inhibits lysosome‑associated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells.
Pan P, Chen T, Zhang Y, Qi Z, Qin J, Cui G, Guo X. | 10/20/2018 |
| A novel data on LAMP-1 overexpression in high grade glioma are presented suggesting involvement of this gene and protein in cell adhesion and tumor progression. | LAMP-1 gene is overexpressed in high grade glioma.
Sarafian VS, Koev I, Mehterov N, Kazakova M, Dangalov K. | 09/8/2018 |
| LAMP1 is involved in the TNM stages and histological differentiation of the esophageal squamous cell carcinoma | Altered expression of lysosomal associated membrane protein 1 in esophageal squamous cell carcinoma.
Huang J, Li L, Liu J, Yu J, Wu X, Xu Y, Ma M, Wang W, Zhang R. | 04/28/2018 |
| LAMP1 has a role in fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens | Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens.
Kirschner A, Thiede M, Blaeschke F, Richter GH, Gerke JS, Baldauf MC, Grünewald TG, Busch DH, Burdach S, Thiel U., Free PMC Article | 02/24/2018 |
| Impaired autophagic pathways were further shown by analyzing late autophagic vesicles; immunostaining with lysosome-associated membrane protein 1 (LAMP-1) antibody revealed enlarged and annular LAMP-1-positive organelles in AMD retinal pigment epithelium (RPE)as opposed to smaller discrete puncta observed in normal RPE | Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration.
Golestaneh N, Chu Y, Xiao YY, Stoleru GL, Theos AC., Free PMC Article | 10/28/2017 |
| The authors show here that human LAMP1 and LAMP2 bind cholesterol in a manner that buries the cholesterol 3beta-hydroxyl group; they also bind tightly to NPC1 and NPC2 proteins that export cholesterol from lysosomes. | Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export.
Li J, Pfeffer SR., Free PMC Article | 10/14/2017 |
| downregulation of FUT1, which leads to the perinuclear localization of LAMP-1 and 2, is correlated with increased rate of autophagic flux by decreasing mTOR signaling and increasing autolysosome formation. | Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells.
Tan KP, Ho MY, Cho HC, Yu J, Hung JT, Yu AL., Free PMC Article | 09/30/2017 |
| the assembly modes of LAMP-1 and LAMP-2 are different, which may underlie their distinct functions | Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes.
Terasawa K, Tomabechi Y, Ikeda M, Ehara H, Kukimoto-Niino M, Wakiyama M, Podyma-Inoue KA, Rajapakshe AR, Watabe T, Shirouzu M, Hara-Yokoyama M. | 06/3/2017 |
| Overexpression of LAMP1 was observed in prostate cancer (PCa) and castration-resistant prostate cancer clinical specimens. Moreover, downstream pathways were identified using si-LAMP1-transfected cells. The discovery of tumor-suppressive miR320a-mediated pathways may provide important insights into the potential mechanisms of PCa metastasis. | Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer.
Okato A, Goto Y, Kurozumi A, Kato M, Kojima S, Matsushita R, Yonemori M, Miyamoto K, Ichikawa T, Seki N., Free PMC Article | 04/1/2017 |
| The data implied that high LAMP1 expression is associated with unfavourable prognosis in laryngeal squamous cell carcinoma patients, and LAMP1 may be identified as a novel prognostic biomarker | LAMP1 expression is associated with malignant behaviours and predicts unfavourable prognosis in laryngeal squamous cell carcinoma.
Lu M, Zhu H, Wang X, Zhang D, Xiong L, Zhu J, Mao Y, Qiang J. | 04/1/2017 |