| Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD. | Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD.
Stadler JT, Bärnthaler T, Borenich A, Emrich IE, Habisch H, Rani A, Holzer M, Madl T, Heine GH, Marsche G., Free PMC Article | 10/3/2024 |
| Rapidly progressive renal failure to reveal LCAT deficiency in an Algerian family. | Rapidly progressive renal failure to reveal LCAT deficiency in an Algerian family.
Khellaf G, Benziane A, Kaci L, Missoum S, Lahmar M, Benabadji M. | 02/16/2023 |
| Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans. | Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans.
Pavanello C, Ossoli A, Strazzella A, Risè P, Veglia F, Lhomme M, Parini P, Calabresi L., Free PMC Article | 07/30/2022 |
| Altered HDL proteome predicts incident CVD in chronic kidney disease patients. | Altered HDL proteome predicts incident CVD in chronic kidney disease patients.
Shao B, Mathew AV, Thornock C, Pennathur S, Michigan Kidney Translational Core CPROBE Investigator Group., Free PMC Article | 03/26/2022 |
| LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred. | LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred.
Mehta R, Elías-López D, Martagón AJ, Pérez-Méndez OA, Sánchez MLO, Segura Y, Tusié MT, Aguilar-Salinas CA., Free PMC Article | 03/19/2022 |
| Genetic, biochemical, and clinical features of LCAT deficiency: update for 2020. | Genetic, biochemical, and clinical features of LCAT deficiency: update for 2020.
Pavanello C, Calabresi L. | 10/23/2021 |
| Esterification of 4beta-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT. | Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT.
Yamamuro D, Yamazaki H, Osuga JI, Okada K, Wakabayashi T, Takei A, Takei S, Takahashi M, Nagashima S, Holleboom AG, Kuroda M, Bujo H, Ishibashi S., Free PMC Article | 10/9/2021 |
| Common plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor. | Common plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor.
Park HM, Kim H, Kim DW, Yoon JH, Kim BG, Cho JY., Free PMC Article | 08/28/2021 |
| Single nucleotide polymorphisms in LCAT may contribute to dyslipidaemia in HIV-infected individuals on HAART in a Ghanaian population. | Single nucleotide polymorphisms in LCAT may contribute to dyslipidaemia in HIV-infected individuals on HAART in a Ghanaian population.
Bani SB, Danquah KO, Obirikorang C, Owiredu WKBA, Quaye L, Muonir Der E, Acheampong E, Adams Y, Dapare PPM, Banyeh M, Anto EO, Sakyi SA., Free PMC Article | 05/15/2021 |
| ApoE and apoC-III-defined HDL subtypes: a descriptive study of their lecithin cholesterol acyl transferase and cholesteryl ester transfer protein content and activity. | ApoE and apoC-III-defined HDL subtypes: a descriptive study of their lecithin cholesterol acyl transferase and cholesteryl ester transfer protein content and activity.
Amaya-Montoya M, Pinzón-Cortés JA, Silva-Bermúdez LS, Ruiz-Manco D, Pérez-Matos MC, Jiménez-Mora MA, Mendivil CO., Free PMC Article | 03/27/2021 |
| LCAT, ApoD, and ApoA1 Expression and Review of Cholesterol Deposition in the Cornea. | LCAT, ApoD, and ApoA1 Expression and Review of Cholesterol Deposition in the Cornea.
Flores R, Jin X, Chang J, Zhang C, Cogan DG, Schaefer EJ, Kruth HS., Free PMC Article | 09/12/2020 |
| The P274S LCAT mutation was found to cause familial LCAT deficiency with renal involvement. | The P274S Mutation of Lecithin-Cholesterol Acyltransferase (LCAT) and Its Clinical Manifestations in a Large Kindred.
Fountoulakis N, Lioudaki E, Lygerou D, Dermitzaki EK, Papakitsou I, Kounali V, Holleboom AG, Stratigis S, Belogianni C, Syngelaki P, Stratakis S, Evangeliou A, Gakiopoulou H, Kuivenhoven JA, Wevers R, Dafnis E, Stylianou K. | 04/4/2020 |
| 7 putative enhancers harboring associated single nucleotide polymorphisms were identified, 3 of which lie within the introns of LCAT and ABCA1, genes that play crucial roles in cholesterol biogenesis and lipoprotein metabolism. | Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism.
Howard AD, Wang X, Prasad M, Sahu AD, Aniba R, Miller M, Hannenhalli S, Chang YC., Free PMC Article | 01/11/2020 |
| Genetic, biochemical, in vitro and in silico analyses indicate that the rare mutations p.M404 V and p.V333 M in LCAT gene lead to suppression of LCAT enzyme activity and cause clinical features of familial LCAT deficiency. | Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia.
Tobar HE, Cataldo LR, González T, Rodríguez R, Serrano V, Arteaga A, Álvarez-Mercado A, Lagos CF, Vicuña L, Miranda JP, Pereira A, Bravo C, Aguilera CM, Eyheramendy S, Uauy R, Martínez Á, Gil Á, Francone O, Rigotti A, Santos JL., Free PMC Article | 12/14/2019 |
| Plasma LCAT mass concentration is upregulated in CAD patients and inversely related to plaque volume, suggesting atheroprotective effects. | Elevated level of lecithin:cholesterol acyltransferase (LCAT) is associated with reduced coronary atheroma burden.
Gebhard C, Rhainds D, He G, Rodés-Cabau J, Lavi S, Spence JD, Title L, Kouz S, L'Allier PL, Grégoire J, Ibrahim R, Cossette M, Guertin MC, Beanlands R, Rhéaume E, Tardif JC. | 11/2/2019 |
| APOA1 may use a reciprocating thumbwheel-like mechanism to activate HDL-remodeling proteins | A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL.
Cooke AL, Morris J, Melchior JT, Street SE, Jerome WG, Huang R, Herr AB, Smith LE, Segrest JP, Remaley AT, Shah AS, Thompson TB, Davidson WS., Free PMC Article | 08/24/2019 |
| Increased LCAT activity may be associated with increased formation of TRLs, leading to a reduction in the LDL-particle size in patients at a high risk for atherosclerotic cardiovascular disease. | Association of lecithin-cholesterol acyltransferase activity and low-density lipoprotein heterogeneity with atherosclerotic cardiovascular disease risk: a longitudinal pilot study.
Yokoyama K, Tani S, Matsuo R, Matsumoto N., Free PMC Article | 08/17/2019 |
| The CETP rs708272 polymorphism is associated with a heightened risk of developing ACS. In addition, we report the association of the rs708272 and rs2292318 polymorphisms with HDL-C levels and HDL subclasses. | CETP and LCAT Gene Polymorphisms Are Associated with High-Density Lipoprotein Subclasses and Acute Coronary Syndrome.
Vargas-Alarcon G, Perez-Mendez O, Herrera-Maya G, Garcia-Sanchez C, Martinez-Rios MA, Peña-Duque MA, Posadas-Sanchez R, Posadas-Romero C, Escobedo G, Fragoso JM. | 07/27/2019 |
| data suggest that Arg123 of apoA-I on discoidal HDL participates in lecithin:cholesterol acyltransferase (LCAT)-mediated cholesterol esterification | Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity.
Gorshkova IN, Mei X, Atkinson D., Free PMC Article | 07/20/2019 |
| the crystal structure of human LCAT in complex with a potent piperidinylpyrazolopyridine activator and an acyl intermediate-like inhibitor, revealing LCAT in an active conformation, is reported. | Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.
Manthei KA, Yang SM, Baljinnyam B, Chang L, Glukhova A, Yuan W, Freeman LA, Maloney DJ, Schwendeman A, Remaley AT, Jadhav A, Tesmer JJ., Free PMC Article | 03/30/2019 |
| Plasma LCAT activity was higher in patients with NAFLD. | Plasma lecithin:cholesterol acyltransferase and phospholipid transfer protein activity independently associate with nonalcoholic fatty liver disease.
Nass KJ, van den Berg EH, Gruppen EG, Dullaart RPF. | 02/2/2019 |
| results demonstrated increased CETP and decreased LCAT and PON-1 activities in colorectal cancer (CRC)patients. In preliminary analysis CETP mass was identified as potential significant predictor of CRC development, suggesting that alterations in HDL-C levels, alongside with changes in HDL structure might have a role in carcinogenesis. | Changes in lecithin: cholesterol acyltransferase, cholesteryl ester transfer protein and paraoxonase-1 activities in patients with colorectal cancer.
Mihajlovic M, Gojkovic T, Vladimirov S, Miljkovic M, Stefanovic A, Vekic J, Zeljkovic D, Trifunovic B, Kotur-Stevuljevic J, Spasojevic-Kalimanovska V, Zeljkovic A. | 01/12/2019 |
| It has been found a significant association between LCAT serum activity and risk of diabetes mellitus in men but not in women. | Impact of serum cholesterol esterification rates on the development of diabetes mellitus in a general population.
Tanaka SI, Fujioka Y, Tsujino T, Ishida T, Hirata KI., Free PMC Article | 11/10/2018 |
| Single Nucleotide Polymorphism in LCAT gene is associated with dyslipidemia. | Interactions among genes involved in reverse cholesterol transport and in the response to environmental factors in dyslipidemia in subjects from the Xinjiang rural area.
Wang X, Guo H, Li Y, Wang H, He J, Mu L, Hu Y, Ma J, Yan Y, Li S, Ding Y, Zhang M, Niu Q, Liu J, Zhang J, Ma R, Guo S., Free PMC Article | 08/4/2018 |
| data suggests a model wherein the active site of LCAT is shielded from soluble substrates by a dynamic lid until it interacts with HDL to allow transesterification to proceed | A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I.
Manthei KA, Ahn J, Glukhova A, Yuan W, Larkin C, Manett TD, Chang L, Shayman JA, Axley MJ, Schwendeman A, Tesmer JJG., Free PMC Article | 01/6/2018 |