| Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK. | Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK.
Keller B, Kfir-Erenfeld S, Matusewicz P, Hartl F, Lev A, Lee YN, Simon AJ, Stauber T, Elpeleg O, Somech R, Stepensky P, Minguet S, Schraven B, Warnatz K., Free PMC Article | 12/29/2023 |
| A Novel Biallelic LCK Variant Resulting in Profound T-Cell Immune Deficiency and Review of the Literature. | A Novel Biallelic LCK Variant Resulting in Profound T-Cell Immune Deficiency and Review of the Literature.
Lanz AL, Erdem S, Ozcan A, Ceylaner G, Cansever M, Ceylaner S, Conca R, Magg T, Acuto O, Latour S, Klein C, Patiroglu T, Unal E, Eken A, Hauck F., Free PMC Article | 12/20/2023 |
| Identification of Breast Cancer LCK Proto-Oncogene as a Master Regulator of TNBC Neutrophil Enrichment and Polarization. | Identification of Breast Cancer LCK Proto-Oncogene as a Master Regulator of TNBC Neutrophil Enrichment and Polarization.
Al Qutami F, Al Halabi W, Hachim MY., Free PMC Article | 09/15/2023 |
| LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer. | LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O., Free PMC Article | 06/30/2023 |
| LCK, FOXC1 and hsa-miR-146a-5p as potential immune effector molecules associated with rheumatoid arthritis. | LCK, FOXC1 and hsa-miR-146a-5p as potential immune effector molecules associated with rheumatoid arthritis.
Chen X, Xie L, Jiang Y, Zhang R, Wu W. | 02/4/2023 |
| A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling. | A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling.
Schultz A, Schnurra M, El-Bizri A, Woessner NM, Hartmann S, Hartig R, Minguet S, Schraven B, Simeoni L., Free PMC Article | 10/8/2022 |
| Role of Programmed Cell Death Protein-1 and Lymphocyte Specific Protein Tyrosine Kinase in the Aryl Hydrocarbon Receptor- Mediated Impairment of the IgM Response in Human CD5(+) Innate-Like B Cells. | Role of Programmed Cell Death Protein-1 and Lymphocyte Specific Protein Tyrosine Kinase in the Aryl Hydrocarbon Receptor- Mediated Impairment of the IgM Response in Human CD5(+) Innate-Like B Cells.
Zhou J, Blevins LK, Crawford RB, Kaminski NE., Free PMC Article | 05/21/2022 |
| Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation. | Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation.
Weiße J, Rosemann J, Müller L, Kappler M, Eckert AW, Glaß M, Misiak D, Hüttelmaier S, Ballhausen WG, Hatzfeld M, Haemmerle M, Gutschner T., Free PMC Article | 01/15/2022 |
| Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling. | Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.
Hartl FA, Ngoenkam J, Beck-Garcia E, Cerqueira L, Wipa P, Paensuwan P, Suriyaphol P, Mishra P, Schraven B, Günther S, Pongcharoen S, Schamel WWA, Minguet S., Free PMC Article | 10/23/2021 |
| A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling. | A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling.
Vico-Barranco I, Arbulo-Echevarria MM, Serrano-García I, Pérez-Linaza A, Miranda-Sayago JM, Miazek A, Narbona-Sánchez I, Aguado E., Free PMC Article | 10/16/2021 |
| The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37. | The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37.
Kowallik S, Kritikos A, Kästle M, Thurm C, Schraven B, Simeoni L., Free PMC Article | 09/18/2021 |
| The role of competing mechanisms on Lck regulation. | The role of competing mechanisms on Lck regulation.
Bozso SJ, Kang JJH, Nagendran J. | 08/28/2021 |
| Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56(Lck) regulates T-cell activation independently of Lck/CD45 interactions. | Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56(Lck) regulates T-cell activation independently of Lck/CD45 interactions.
Kästle M, Merten C, Hartig R, Kaehne T, Liaunardy-Jopeace A, Woessner NM, Schamel WW, James J, Minguet S, Simeoni L, Schraven B., Free PMC Article | 08/14/2021 |
| Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. | Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.
Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, Jacobs K, Broux M, Verhoef G, Michaux L, Graux C, Wlodarska I, Gaulard P, de Leval L, Tousseyn T, Cools J, Dierickx D., Free PMC Article | 07/10/2021 |
| LCK expression is a potential biomarker for distinguishing primary central nervous system lymphoma from glioblastoma multiforme. | LCK expression is a potential biomarker for distinguishing primary central nervous system lymphoma from glioblastoma multiforme.
Ge L, Xu L, Lu S, Yan H., Free PMC Article | 07/10/2021 |
| LCK rs10914542-G allele associates with type 1 diabetes in children via T cell hyporesponsiveness. | LCK rs10914542-G allele associates with type 1 diabetes in children via T cell hyporesponsiveness.
Zhu Q, Wang J, Zhang L, Bian W, Lin M, Xu X, Zhou X. | 08/22/2020 |
| These results show that both the activation and deactivation processes could follow distinct pathways, differentiated by the order by which the A-loop and the C-helix regions rearrange. | On the activation and deactivation pathways of the Lck kinase domain: a computational study.
Alba J, Milanetti E, D'Abramo M. | 07/25/2020 |
| The ITK SH3 and LCK SH3 domains can both competefor and simultaneously bind to adjacent binding sites on TSAD encompassing aa 242-268. | The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein.
Andersen TCB, Kristiansen PE, Huszenicza Z, Johansson MU, Gopalakrishnan RP, Kjelstrup H, Boyken S, Sundvold-Gjerstad V, Granum S, Sørli M, Backe PH, Fulton DB, Karlsson BG, Andreotti AH, Spurkland A., Free PMC Article | 06/27/2020 |
| These findings suggest TSLP/p56lck plays an important role in allergic reactions and offers opportunities for the development of novel drugs for the treatment of AR. | Src-type tyrosine kinase p56lck is critical for thymic stromal lymphopoietin-induced allergic rhinitis.
Nam SY, Kim HY, Han NR, Moon PD, Cho JS, Kim HM, Jeong HJ. | 11/16/2019 |
| these results provide strong evidence that mutated and overexpressed Lck is driving acute myeloid leukemia cell, CTV-1, proliferation | Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1.
Li L, Cui Y, Shen J, Dobson H, Sun G. | 11/9/2019 |
| this study shows that LSK expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature | Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature.
Hinchcliff E, Paquette C, Roszik J, Kelting S, Stoler MH, Mok SC, Yeung TL, Zhang Q, Yates M, Peng W, Hwu P, Jazaeri A., Free PMC Article | 11/2/2019 |
| inducible CRISPR/Cas9-targeted LCK deletion decreased YAPY357 phosphorylation and its nuclear localization. The importance of LCK in cholangiocarcinoma (CCA) biology was demonstrated by clinical observations suggesting LCK expression levels were associated with early tumor recurrence following resection of CCA | YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity.
Sugihara T, Werneburg NW, Hernandez MC, Yang L, Kabashima A, Hirsova P, Yohanathan L, Sosa C, Truty MJ, Vasmatzis G, Gores GJ, Smoot RL., Free PMC Article | 08/3/2019 |
| we show that HIV-1 infection of human T cells sequesters both Lck and Rac1 in a pericentrosomal compartment in an Nef-dependent manner. | HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton-Mediated T Cell Functions.
Del Río-Iñiguez I, Vázquez-Chávez E, Cuche C, Di Bartolo V, Bouchet J, Alcover A. | 07/20/2019 |
| Data find Lck expression and disease outcome in chronic lymphocytic leukaemia (CLL) are unrelated despite observations that its inhibition produces effects that biologically resemble the egress phenotype taken on by CLL cells treated with idelalisib. | Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome.
Till KJ, Allen JC, Talab F, Lin K, Allsup D, Cawkwell L, Bentley A, Ringshausen I, Duckworth AD, Pettitt AR, Kalakonda N, Slupsky JR., Free PMC Article | 07/20/2019 |
| Results show that Lck is highly expressed in human glioblastoma and regulates the formation of pseudopodia and the migration of human glioma cells as well as the regulation of cancer stemness. | Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor.
Zepecki JP, Snyder KM, Moreno MM, Fajardo E, Fiser A, Ness J, Sarkar A, Toms SA, Tapinos N., Free PMC Article | 05/18/2019 |