| WTAP Mediates NUPR1 Regulation of LCN2 Through m[6]A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion. | WTAP Mediates NUPR1 Regulation of LCN2 Through m(6)A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion.
Tan M, He Y, Yi J, Chen J, Guo Q, Liao N, Peng L. | 04/25/2024 |
| SLP76 Mutation Associated with Combined Immunodeficiency and EBV-Related Lymphoma. | SLP76 Mutation Associated with Combined Immunodeficiency and EBV-Related Lymphoma.
Lev A, Asleh M, Levy S, Lee YN, Simon AJ, Stepensky P, Nalbandyan K, Nahum A, Ben-Harosh M, Yablonski D, Broides A, Somech R. | 03/3/2023 |
| STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease. | STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease.
Yu YL, Chen M, Zhu H, Zhuo MX, Chen P, Mao YJ, Li LY, Zhao Q, Wu M, Ye M., Free PMC Article | 01/29/2022 |
| Lymphocyte cytosolic protein 2 is a novel prognostic marker in lung adenocarcinoma. | Lymphocyte cytosolic protein 2 is a novel prognostic marker in lung adenocarcinoma.
Huo Y, Zhang K, Han S, Feng Y, Bao Y., Free PMC Article | 12/18/2021 |
| A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8(+) T cells. | A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8(+) T cells.
Wang Z, Peng M., Free PMC Article | 10/23/2021 |
| The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. | The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.
Soini L, Leysen S, Davis J, Westwood M, Ottmann C. | 07/31/2021 |
| Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis. | Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis.
Yan Z, Luo H, Xie B, Tian T, Li S, Chen Z, Liu J, Zhao X, Zhang L, Deng Y, Billiar TR, Jiang Y., Free PMC Article | 01/23/2021 |
| Findings reveal that ADAP acts upstream of SLP-76 to convert labile, Ca(2+)-competent microclusters into stable adhesive junctions with enhanced signaling potential. | ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters.
Lewis JB, Scangarello FA, Murphy JM, Eidell KP, Sodipo MO, Ophir MJ, Sargeant R, Seminario MC, Bunnell SC., Free PMC Article | 01/11/2020 |
| a previously unappreciated role for PLC-gamma1 in the positive regulation of Zap-70 and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck substrate phosphorylation sites within this complex. | A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.
Belmont J, Gu T, Mudd A, Salomon AR., Free PMC Article | 05/19/2018 |
| These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6. | T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.
Breuning J, Brown MH., Free PMC Article | 09/16/2017 |
| LAT and SLP-76 are randomly dispersed throughout the clusters that form upon T cell receptor engagement. | Development of nanoscale structure in LAT-based signaling complexes.
Barr VA, Sherman E, Yi J, Akpan I, Rouquette-Jazdanian AK, Samelson LE., Free PMC Article | 08/5/2017 |
| SLP76 is ectopically expressed in chronic lymphocytic leukemia cells where it plays a role in B-cell receptor signaling. | SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course.
Dezorella N, Katz BZ, Shapiro M, Polliack A, Perry C, Herishanu Y., Free PMC Article | 07/1/2017 |
| findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells. | Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.
Thaker YR, Recino A, Raab M, Jabeen A, Wallberg M, Fernandez N, Rudd CE., Free PMC Article | 04/29/2017 |
| Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation. | Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1.
Dios-Esponera A, Isern de Val S, Sevilla-Movilla S, García-Verdugo R, García-Bernal D, Arellano-Sánchez N, Cabañas C, Teixidó J., Free PMC Article | 07/2/2016 |
| TSAD binds to and co-localizes with Nck. Expression of TSAD increases both Nck-Lck and Nck-SLP-76 interaction in T cells. | T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells.
Hem CD, Sundvold-Gjerstad V, Granum S, Koll L, Abrahamsen G, Buday L, Spurkland A., Free PMC Article | 03/12/2016 |
| immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells | The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.
Liu H, Schneider H, Recino A, Richardson C, Goldberg MW, Rudd CE., Free PMC Article | 11/28/2015 |
| SLP-76 N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor signaling | SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling.
Ji Q, Ding Y, Salomon AR., Free PMC Article | 09/5/2015 |
| analysis of a costimulatory mechanism by which CXCL12 and antigen converge at SLP-76 microcluster formation to enhance T cell responses | The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76.
Smith X, Schneider H, Köhler K, Liu H, Lu Y, Rudd CE. | 02/22/2014 |
| Multipoint binding of SLP-76 to ADAP facilitates the assembly of SLP-76 microclusters. | Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.
Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE., Free PMC Article | 12/14/2013 |
| Data indicate a role for the SAM domain in mediating SLP-76 self-association for T-cell function. | SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.
Liu H, Thaker YR, Stagg L, Schneider H, Ladbury JE, Rudd CE., Free PMC Article | 12/14/2013 |
| Data indicate that the intracellular signaling of ITK-SYK requires both SLP-76 and the adapter function of SYK/ZAP-70 kinases. | Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.
Hussain A, Mohammad DK, Gustafsson MO, Uslu M, Hamasy A, Nore BF, Mohamed AJ, Smith CI., Free PMC Article | 05/4/2013 |
| Unique modes of regulation of positive and negative feedback pathways in T cells by SLP-76. | Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells.
Cao L, Ding Y, Hung N, Yu K, Ritz A, Raphael BJ, Salomon AR., Free PMC Article | 04/6/2013 |
| These findings reveal a novel role for SLP-76 in CXCR4-mediated T lymphocyte trafficking. | SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.
Lee D, Kim J, Baker RG, Koretzky GA, Hammer DA., Free PMC Article | 01/12/2013 |
| a novel regulation mechanism of SLP-76 by ubiquitination and proteasomal degradation of activated SLP-76, which is mediated by Ser-376 phosphorylation, leading to down-regulation of TCR signaling. | Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein.
Wang X, Li JP, Chiu LL, Lan JL, Chen DY, Boomer J, Tan TH., Free PMC Article | 01/5/2013 |
| Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells. | Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells.
Kim HS, Long EO., Free PMC Article | 11/17/2012 |