| Regulatory T Cell Apoptosis during Preeclampsia May Be Prevented by Gal-2. | Regulatory T Cell Apoptosis during Preeclampsia May Be Prevented by Gal-2.
Meister S, Hahn L, Beyer S, Mannewitz M, Perleberg C, Schnell K, Anz D, Corradini S, Schmoeckel E, Mayr D, Hasbargen U, Zati Zehni A, Mahner S, Jeschke U, Kolben T., Free PMC Article | 03/12/2022 |
| Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in patients with rheumatoid arthritis. | Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in patients with rheumatoid arthritis.
Xu WD, Wu Q, He YW, Huang AF, Lan YY, Fu L, Zhou J, Liu XY. | 12/25/2021 |
| Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia. | Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia.
Charkiewicz K, Goscik J, Raba G, Laudanski P. | 07/24/2021 |
| Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth. | Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth.
Li H, Zhao L, Lau YS, Zhang C, Han R., Free PMC Article | 04/17/2021 |
| Placental Galectin-2 Expression in Gestational Diabetes: A Systematic, Histological Analysis. | Placental Galectin-2 Expression in Gestational Diabetes: A Systematic, Histological Analysis.
Hepp P, Unverdorben L, Hutter S, Kuhn C, Ditsch N, Groß E, Mahner S, Jeschke U, Knabl J, Heidegger HH., Free PMC Article | 01/9/2021 |
| Study observed decreased methylation at the DHCR24 locus in offspring of women with active pregnancy eating disorders (ED) and increased methylation at the LGALS2 locus in offspring of women with past ED compared to controls. | Maternal eating disorders affect offspring cord blood DNA methylation: a prospective study.
Kazmi N, Gaunt TR, Relton C, Micali N., Free PMC Article | 07/14/2018 |
| Data show that lactose binding to galectin-2 (Gal-2) stabilizes the lectin's conformation. | Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutination.
Si Y, Feng S, Gao J, Wang Y, Zhang Z, Meng Y, Zhou Y, Tai G, Su J. | 03/4/2017 |
| Gal-3 was significantly downregulated only in the extravillous trophoblast of intrauterine growth restriction ( IUGR) placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas. | Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR).
Hutter S, Knabl J, Andergassen U, Hofmann S, Kuhn C, Mahner S, Arck P, Jeschke U., Free PMC Article | 12/17/2016 |
| Galectin-1 was undetectable in normal and ulcerative colitis colonic epithelium, while galectin-2, galectin-3, and galectin-4 were strongly expressed. | Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis.
Block M, Mölne J, Leffler H, Börjesson L, Breimer ME., Free PMC Article | 11/12/2016 |
| Galectin-2 binding to different circulating human monocyte subsets depends on monocyte surface expression levels of CD14. It skews human macrophages to a M1-like proinflammatory phenotype. | Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages.
Yıldırım C, Vogel DY, Hollander MR, Baggen JM, Fontijn RD, Nieuwenhuis S, Haverkamp A, de Vries MR, Quax PH, Garcia-Vallejo JJ, van der Laan AM, Dijkstra CD, van der Pouw Kraan TC, van Royen N, Horrevoets AJ., Free PMC Article | 04/16/2016 |
| PPARG rs1152002, AGTR1 rs5186, CXCL16 rs3744700 and LGALS2 rs7291467 polymorphisms may be closely related to the development of coronary heart disease | PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease.
Tian J, Hu S, Wang F, Yang X, Li Y, Huang C., Free PMC Article | 04/2/2016 |
| Lower LGALS2 gene expression is associated with acute myeloid leukemia. | Expression profiling of cancer-related galectins in acute myeloid leukemia.
El Leithy AA, Helwa R, Assem MM, Hassan NH. | 01/30/2016 |
| Data suggest that expression of galectin 2 and galectin 2 mRNA is down-regulated in placental extravillous trophoblast and decidua in women with pre-eclampsia as compared to women with normal term pregnancy. | Galectin 2 (gal-2) expression is downregulated on protein and mRNA level in placentas of preeclamptic (PE) patients.
Hutter S, Martin N, von Schönfeldt V, Messner J, Kuhn C, Hofmann S, Andergassen U, Knabl J, Jeschke U. | 12/12/2015 |
| Gal-1, 2, and 3 levels were high in maintenance hemodialysis patients. Kidney transplantation improved gal-1, 2, and 3 levels. | Alternations of galectin levels after renal transplantation.
Tan R, Liu X, Wang J, Lu P, Han Z, Tao J, Yin C, Gu M. | 06/20/2015 |
| The increased circulation of galectins -2, -4 and -8 in cancer patients contributes substantially to the increased circulation of G-CSF, IL-6 and MCP-1 by interaction with the blood vascular endothelium | Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis.
Chen C, Duckworth CA, Fu B, Pritchard DM, Rhodes JM, Yu LG., Free PMC Article | 04/12/2014 |
| Cys57Met (single-site) mutant and its monoPEGylated derivative can markedly reduce binding of galectin-2 to physiological binding sites | Single-site mutational engineering and following monoPEGylation of the human lectin galectin-2: effects on ligand binding, functional aspects, and clearance from serum.
Kopitz J, Fik Z, André S, Smetana K Jr, Gabius HJ. | 12/21/2013 |
| results identify galectin-2 as a novel inhibitor of arteriogenesis and its modulation may constitute a new therapeutic strategy for the stimulation of arteriogenesis in patients with coronary artery disease. | Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis.
van der Laan AM, Schirmer SH, de Vries MR, Koning JJ, Volger OL, Fledderus JO, Bastiaansen AJ, Hollander MR, Baggen JM, Koch KT, Baan J Jr, Henriques JP, van der Schaaf RJ, Vis MM, Mebius RE, van der Pouw Kraan TC, Quax PH, Piek JJ, Horrevoets AJ, van Royen N. | 08/18/2012 |
| LTA and LGALS2 polymorphisms affect the subclinical phenotype of the coronary artery, which predisposes to the incidence of myocardial infarction. | Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: a pathological study of 1503 consecutive autopsy cases.
Ikeda S, Tanaka N, Arai T, Chida K, Muramatsu M, Sawabe M. | 07/28/2012 |
| low expression of galectin-2 was significantly associated with lymph node metastasis and advanced clinical stage in patients with gastric cancer | Lowered expression of galectin-2 is associated with lymph node metastasis in gastric cancer.
Jung JH, Kim HJ, Yeom J, Yoo C, Shin J, Yoo J, Kang CS, Lee C. | 06/2/2012 |
| Data indicate that Gal-1, Gal-2, Gal-4, and partly Gal-3 bound to monocytes/macrophages. | Galectins distinctively regulate central monocyte and macrophage function.
Paclik D, Werner L, Guckelberger O, Wiedenmann B, Sturm A. | 12/10/2011 |
| Studies developed an ultimate rule for galectin recognition of disaccharides. | The Galβ-(syn)-gauche configuration is required for galectin-recognition disaccharides.
Iwaki J, Tateno H, Nishi N, Minamisawa T, Nakamura-Tsuruta S, Itakura Y, Kominami J, Urashima T, Nakamura T, Hirabayashi J. | 08/27/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| These results suggested differences in the inflammatory response to malaria in children and adults with polymorphisms of the galectin-2 gene. | Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans.
Randall LM, Kenangalem E, Lampah DA, Tjitra E, Mwaikambo ED, Handojo T, Piera KA, Zhao ZZ, de Labastida Rivera F, Zhou Y, McSweeney KM, Le L, Amante FH, Haque A, Stanley AC, Woodberry T, Salwati E, Granger DL, Hobbs MR, Price RN, Weinberg JB, Montgomery GW, Anstey NM, Engwerda CR., Free PMC Article | 06/28/2010 |
| the LTA gene and LGALS2-C3279T are not associated with coronary artery disease | Lack of association between lymphotoxin-alpha, galectin-2 polymorphisms and coronary artery disease: a meta-analysis.
Li W, Xu J, Wang X, Chen J, Zhang C, Sun K, Hui R. | 04/19/2010 |