| Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1. | Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1.
Droessler L, Cornelius V, Markov AG, Amasheh S., Free PMC Article | 10/9/2021 |
| The present study showed that TNF-alpha, which was secreted by the tracheal epithelial cells when they were stimulated with several swine pathogens, damaged tight junction proteins and disrupted the epithelial barrier of a pig tracheal epithelial cell model. | TNF-α disrupts the integrity of the porcine respiratory epithelial barrier.
Bercier P, Grenier D. | 08/10/2019 |
| Mechanistically, Porcine productive and respiratory syndrome virus induced an elevated level of tumor necrosis factor (TNF-alpha), through the nuclear factor kappaB (NF-kappaB) signaling pathway to inhibit the replication of classical swine fever virus -C in vitro. | TNF-α induced by porcine reproductive and respiratory syndrome virus inhibits the replication of classical swine fever virus C-strain.
Chen D, Liu X, Xu S, Chen D, Zhou L, Ge X, Han J, Guo X, Yang H. | 08/10/2019 |
| this study shows of TNF-alpha to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model | Contribution of IL-1β, 6 and TNF-α to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model.
Han PF, Wei L, Duan ZQ, Zhang ZL, Chen TY, Lu JG, Zhao RP, Cao XM, Li PC, Lv Z, Wei XC. | 05/18/2019 |
| these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy | Production of porcine TNFα by ADAM17-mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection.
Li R, Guo L, Gu W, Luo X, Zhang J, Xu Y, Tian Z, Feng L, Wang Y. | 12/16/2017 |
| TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes. | Effects of Trimetazidine on PDCD4/NF-κB/TNF-α Pathway in Coronary Microembolization.
Su Q, Li L, Zhao J, Sun Y, Yang H. | 08/5/2017 |
| TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 and essential retinal pigment epithelium genes. | Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-α.
Mathis T, Housset M, Eandi C, Beguier F, Touhami S, Reichman S, Augustin S, Gondouin P, Sahel JA, Kodjikian L, Goureau O, Guillonneau X, Sennlaub F., Free PMC Article | 06/10/2017 |
| TNF-alpha induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle. | Cyclic Tensile Strain Reduces TNF-α Induced Expression of MMP-13 by Condylar Temporomandibular Joint Cells.
Tabeian H, Bakker AD, Betti BF, Lobbezoo F, Everts V, de Vries TJ. | 05/20/2017 |
| TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries. | Effects of interleukin 6 and tumor necrosis factor-α on the proliferation of porcine theca interna cells: Possible role of these cytokines in the pathogenesis of polycystic ovary syndrome.
Hong L, Zhang Y, Wang Q, Han Y, Teng X. | 04/29/2017 |
| This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 resistance. | Effects of the -791(C→T) mutation in the promoter for tumor necrosis factor alpha on gene expression and resistance of Large White pigs to enterotoxigenic Escherichia coli F18.
Liu Y, Dai C, Sun L, Zhu G, Wu S, Bao W., Free PMC Article | 03/18/2017 |
| Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages. | Both Nsp1β and Nsp11 are responsible for differential TNF-α production induced by porcine reproductive and respiratory syndrome virus strains with different pathogenicity in vitro.
He Q, Li Y, Zhou L, Ge X, Guo X, Yang H. | 01/16/2016 |
| Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta, IL-8 and TNF-alpha in porcine alveolar macrophages. | Mechanisms underlying Actinobacillus pleuropneumoniae exotoxin ApxI induced expression of IL-1β, IL-8 and TNF-α in porcine alveolar macrophages.
Chen ZW, Chien MS, Chang NY, Chen TH, Wu CM, Huang C, Lee WC, Hsuan SL., Free PMC Article | 07/5/2014 |
| the role of miR-181a in adipocyte differentiation by regulation of TNF-alpha | MiRNA-181a regulates adipogenesis by targeting tumor necrosis factor-α (TNF-α) in the porcine model.
Li H, Chen X, Guan L, Qi Q, Shu G, Jiang Q, Yuan L, Xi Q, Zhang Y., Free PMC Article | 06/28/2014 |
| The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability. | Combined treatment of hydroxytyrosol with carbon monoxide-releasing molecule-2 prevents TNF α-induced vascular endothelial cell dysfunction through NO production with subsequent NFκB inactivation.
Zrelli H, Wu CW, Zghonda N, Shimizu H, Miyazaki H., Free PMC Article | 06/7/2014 |
| High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation. | High-volume hemofiltration reduces the expression of myocardial tumor necrosis factor-alpha in septic shock pigs.
Li C, Zhang P, Cheng X, Chen J. | 07/27/2013 |
| Basal lipogenesis was not affected by tumor necrosis factor alpha (TNFalpha) treatment; however, insulin stimulated lipogenesis was reduced by TNFalpha. Interleukin 6 and TNFalpha gene expression were acutely (2-4 h) stimulated by exogenous TNFalpha treatment. | Peripheral tumor necrosis factor α regulation of adipose tissue metabolism and adipokine gene expression in neonatal pigs.
Ramsay TG, Stoll MJ, Conde-Aguilera JA, Caperna TJ. | 07/27/2013 |
| In swine, IL-8, TNF-ALPHA, INOS AND MIP-1BETA were increased during mechanical ventilation in a time-related fashion. | Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1β proteins in pigs.
Vobruba V, Klimenko OV, Kobr J, Cerna O, Pokorna P, Mikula I, Hridel J, Brantova O, Martasek P. | 07/13/2013 |
| These data demonstrate that CRF triggers increases in intestinal paracellular permeability via mast cell dependent release of TNF-alpha and proteases. | CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α.
Overman EL, Rivier JE, Moeser AJ., Free PMC Article | 12/8/2012 |
| We identified critical amino acid residues in PRRSV Nsp1alpha and Nsp1beta that are important for TNF-alpha down-regulation and attenuation in vivo. | Amino acid residues in the non-structural protein 1 of porcine reproductive and respiratory syndrome virus involved in down-regulation of TNF-α expression in vitro and attenuation in vivo.
Subramaniam S, Beura LK, Kwon B, Pattnaik AK, Osorio FA. | 11/17/2012 |
| Porcine reproductive and respiratory syndrome virus infection impaired TNF-alpha production by inhibiting ERK signaling. pathway. | Highly pathogenic porcine reproductive and respiratory syndrome virus impairs LPS- and poly(I:C)-stimulated tumor necrosis factor-alpha release by inhibiting ERK signaling pathway.
Hou J, Wang L, He W, Zhang H, Feng WH. | 10/13/2012 |
| Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions. | Signaling molecules for early detection of adverse interactions during mechanical ventilation in animal models.
Kobr J, Pizingerova K, Fremuth J, Sasek L, Kocova J, Hes O, Racek J, Topolcan O. | 07/23/2011 |
| These results suggest that trans-10, cis-12-conjugated linoleic acid can modulate TNF-alpha production and NF-kappa B expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells. | Trans-10, cis-12-conjugated linoleic acid modulates NF-κB activation and TNF-α production in porcine peripheral blood mononuclear cells via a PPARγ-dependent pathway.
Kim DI, Kim KH, Kang JH, Jung EM, Kim SS, Jeung EB, Yang MP. | 07/2/2011 |
| Retinal ischemia results in increased expression of TNF-alpha and its receptors (TNF-R1 and TNF-R2). | Tumor necrosis factor and its receptors in the neuroretina and retinal vasculature after ischemia-reperfusion injury in the pig retina.
Gesslein B, Håkansson G, Gustafsson L, Ekström P, Malmsjö M., Free PMC Article | 02/26/2011 |
| increased plasma levels during recovery from cardiac arrest are associated with left ventricle dysfunction | Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swine.
Niemann JT, Rosborough JP, Youngquist S, Shah AP, Lewis RJ, Phan QT, Filler SG., Free PMC Article | 11/27/2010 |
| Viral non-structural protein 1 suppressed host TNF-alpha promoter by inhibiting NF-kappaB and Sp1 promoter binding activity. | Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-κB and Sp1.
Subramaniam S, Kwon B, Beura LK, Kuszynski CA, Pattnaik AK, Osorio FA. | 10/23/2010 |