| Dorsal visual stream and LIMK1: hemideletion, haplotype, and enduring effects in children with Williams syndrome. | Dorsal visual stream and LIMK1: hemideletion, haplotype, and enduring effects in children with Williams syndrome.
Kippenhan JS, Gregory MD, Nash T, Kohn P, Mervis CB, Eisenberg DP, Garvey MH, Roe K, Morris CA, Kolachana B, Pani AM, Sorcher L, Berman KF., Free PMC Article | 08/30/2023 |
| The Activation of the LIMK/Cofilin Signaling Pathway via Extracellular Matrix-Integrin Interactions Is Critical for the Generation of Mature and Vascularized Cardiac Organoids. | The Activation of the LIMK/Cofilin Signaling Pathway via Extracellular Matrix-Integrin Interactions Is Critical for the Generation of Mature and Vascularized Cardiac Organoids.
Noh JM, Choi SC, Song MH, Kim KS, Jun S, Park JH, Kim JH, Kim K, Ko TH, Choi JI, Gim JA, Kim JH, Jang Y, Park Y, Na JE, Rhyu IJ, Lim DS., Free PMC Article | 08/28/2023 |
| The Diagnostic and Prognostic Value of LIMK1/2: A Pan-Cancer Analysis. | The Diagnostic and Prognostic Value of LIMK1/2: A Pan-Cancer Analysis.
Li J, Liu Y, Zheng L. | 02/12/2022 |
| LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target. | LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target.
Kang X, Li W, Liu W, Liang H, Deng J, Wong CC, Zhao S, Kang W, To KF, Chiu PWY, Wang G, Yu J, Ng EKW., Free PMC Article | 01/15/2022 |
| Long non-coding RNA Lnc-408 promotes invasion and metastasis of breast cancer cell by regulating LIMK1. | Long non-coding RNA Lnc-408 promotes invasion and metastasis of breast cancer cell by regulating LIMK1.
Qiao Y, Jin T, Guan S, Cheng S, Wen S, Zeng H, Zhao M, Yang L, Wan X, Qiu Y, Li Q, Liu M, Hou Y., Free PMC Article | 12/25/2021 |
| Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics. | Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics.
Rodríguez-Fernández L, Company S, Zaragozá R, Viña JR, García-Trevijano ER., Free PMC Article | 11/13/2021 |
| FOXD3AS1/miR1283p/LIMK1 axis regulates cervical cancer progression. | FOXD3‑AS1/miR‑128‑3p/LIMK1 axis regulates cervical cancer progression.
Yang X, Du H, Bian W, Li Q, Sun H., Free PMC Article | 11/6/2021 |
| LIMK1 nuclear translocation promotes hepatocellular carcinoma progression by increasing p-ERK nuclear shuttling and by activating c-Myc signalling upon EGF stimulation. | LIMK1 nuclear translocation promotes hepatocellular carcinoma progression by increasing p-ERK nuclear shuttling and by activating c-Myc signalling upon EGF stimulation.
Pan Z, Liu C, Zhi Y, Xie Z, Wu L, Jiang M, Zhang Y, Zhou R, Zhao L. | 10/23/2021 |
| Effects of PAK4/LIMK1/Cofilin-1 signaling pathway on proliferation, invasion, and migration of human osteosarcoma cells. | Effects of PAK4/LIMK1/Cofilin-1 signaling pathway on proliferation, invasion, and migration of human osteosarcoma cells.
Li ZF, Yao YD, Zhao YY, Liu Y, Liu ZH, Hu P, Zhu ZR., Free PMC Article | 07/17/2021 |
| Alantolactone suppresses the metastatic phenotype and induces the apoptosis of glioblastoma cells by targeting LIMK kinase activity and activating the cofilin/Gactin signaling cascade. | Alantolactone suppresses the metastatic phenotype and induces the apoptosis of glioblastoma cells by targeting LIMK kinase activity and activating the cofilin/G‑actin signaling cascade.
Wang X, Zou S, Ren T, Zhao LJ, Yu LF, Li XY, Yan X, Zhang LJ., Free PMC Article | 07/17/2021 |
| [Regulatory effects of LIM kinase 1 on the proliferation and metastasis of hepatocellular carcinoma cells]. | [Regulatory effects of LIM kinase 1 on the proliferation and metastasis of hepatocellular carcinoma cells].
Guo D, Li YR, Chen DF, Wang RH, Zhang D, Zhu M, He SX, Lu XL. | 07/3/2021 |
| Up-regulation of LIMK1 expression in prostate cancer is correlated with poor pathological features, lymph node metastases and biochemical recurrence. | Up-regulation of LIMK1 expression in prostate cancer is correlated with poor pathological features, lymph node metastases and biochemical recurrence.
Huang JB, Wu YP, Lin YZ, Cai H, Chen SH, Sun XL, Li XD, Wei Y, Zheng QS, Xu N, Xue XY., Free PMC Article | 05/1/2021 |
| ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly. | ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly.
Tixeira R, Phan TK, Caruso S, Shi B, Atkin-Smith GK, Nedeva C, Chow JDY, Puthalakath H, Hulett MD, Herold MJ, Poon IKH., Free PMC Article | 04/3/2021 |
| Human NK Cell Cytoskeletal Dynamics and Cytotoxicity Are Regulated by LIM Kinase. | Human NK Cell Cytoskeletal Dynamics and Cytotoxicity Are Regulated by LIM Kinase.
Duvall MG, Fuhlbrigge ME, Reilly RB, Walker KH, Kılıç A, Levy BD., Free PMC Article | 03/20/2021 |
| MiR-429-5p attenuates the migration and invasion of malignant melanoma by targeting LIMK1. | MiR-429-5p attenuates the migration and invasion of malignant melanoma by targeting LIMK1.
Sheng H, Guo YH, Cao DS, Li XJ, Zhao Y, Ding H, Zhang YL, Chen ZH. | 03/20/2021 |
| Circular RNA hsa_circ_0012673 facilitates lung cancer cell proliferation and invasion via miR-320a/LIMK18521 axis. | Circular RNA hsa_circ_0012673 facilitates lung cancer cell proliferation and invasion via miR-320a/LIMK18521 axis.
Qin H, Liu J, Du ZH, Hu R, Yu YK, Wang QA. | 03/20/2021 |
| Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway. | Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway.
Zeng Y, Ren M, Li Y, Liu Y, Chen C, Su J, Su B, Xia H, Liu F, Jiang H, Ling H, Zeng X, Su Q. | 02/20/2021 |
| LIMK1 depletion enhances fasudil-dependent inhibition of urethral fibroblast proliferation and migration. | LIMK1 depletion enhances fasudil-dependent inhibition of urethral fibroblast proliferation and migration.
Liang YC, Li XD, Wu YP, Ke ZB, Liu ZQ, Chen SH, Wei Y, Zheng QS, Xue XY, Xu N. | 08/15/2020 |
| LIMK1 robustly phosphorylates both serine and tyrosine residues, establishing LIMK1 as a dual-specificity kinase. | Lessons from LIMK1 enzymology and their impact on inhibitor design.
Salah E, Chatterjee D, Beltrami A, Tumber A, Preuss F, Canning P, Chaikuad A, Knaus P, Knapp S, Bullock AN, Mathea S., Free PMC Article | 07/11/2020 |
| It has been found that LIMK1/LIMK2 is critical for GPER activation-induced breast cancer cell migration. | GPER stabilizes F-actin cytoskeleton and activates TAZ via PLCβ-PKC and Rho/ROCK-LIMK-Cofilin pathway.
Wang Z, Sun L, Liang S, Liu ZC, Zhao ZY, Yang J, Wang D, Yang DQ. | 07/11/2020 |
| LIMK1and LIMK2 expression status is associated with glioblastoma (GBM) grade and poor prognosis. Simultaneous knockdown of both isoforms strongly reduced the invasive motility of continuous culture models and human GBM tumor-initiating cells. LIMK1/2 functionally regulated cell invasiveness, in part, by disrupting polarized cell motility under confinement and cell chemotaxis. | Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion.
Chen J, Ananthanarayanan B, Springer KS, Wolf KJ, Sheyman SM, Tran VD, Kumar S., Free PMC Article | 06/20/2020 |
| ROCK1 and ROCK2 regulated cell proliferation in PC-3 and DU145 prostate cancer cells. Protein levels of phosphorylated LIM kinase 1 (p-LIMK1) and matrix metalloproteinase-2 (MMP-2) were reduced in ROCK1 and ROCK2 siRNA transfected cells. CONCLUSIONS In PC-3 and DU145 human prostate cancer cells, ROCK promoted cell proliferation and migration by targeting LIMK1 and MMP-2. | Rho-Associated Protein Kinase (ROCK) Promotes Proliferation and Migration of PC-3 and DU145 Prostate Cancer Cells by Targeting LIM Kinase 1 (LIMK1) and Matrix Metalloproteinase-2 (MMP-2).
Gong H, Zhou L, Khelfat L, Qiu G, Wang Y, Mao K, Chen W., Free PMC Article | 09/21/2019 |
| Our findings revealed that increased LIMK1 protein levels may contribute to atrial fibrosis, and suggested that LIMK1 might be involved in AF development by promoting fibrogenesis associated with TGF-beta | LIM kinase 1 acts as a profibrotic mediator in permanent atrial fibrillation patients with valvular heart disease.
Chen Q, Gimple RC, Li G, Chen J, Wu H, Li R, Xie J, Xu B. | 06/22/2019 |
| Results show that silencing LIMK1 leads to defective spindle organization and centrosome integrity. Dynein light intermediate chains were identified as the downstream mediators of LIMK1 in the maintenance of centrosome integrity. | LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains.
Ou S, Tan MH, Weng T, Li H, Koh CG., Free PMC Article | 03/23/2019 |
| Results indicated that LIM kinase 1 was a potential target molecule for the inhibitory effect of diallyl disulfide on colon cancer cell migration and invasion. | Downregulation of LIMK1-ADF/cofilin by DADS inhibits the migration and invasion of colon cancer.
Su J, Zhou Y, Pan Z, Shi L, Yang J, Liao A, Liao Q, Su Q., Free PMC Article | 12/1/2018 |