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    FADS1 fatty acid desaturase 1 [ Homo sapiens (human) ]

    Gene ID: 3992, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    High Frequency of Ancestral Haplotype A of Fatty Acid Desaturase Genes in the Yakut Population.

    High Frequency of Ancestral Haplotype A of Fatty Acid Desaturase Genes in the Yakut Population.
    Pavlova NI, Krylov AV, Bochurov AA, Alekseev VA, Kurtanov KA.

    09/20/2024
    FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer.

    FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer.
    Lorito N, Subbiani A, Smiriglia A, Bacci M, Bonechi F, Tronci L, Romano E, Corrado A, Longo DL, Iozzo M, Ippolito L, Comito G, Giannoni E, Meattini I, Avgustinova A, Chiarugi P, Bachi A, Morandi A., Free PMC Article

    08/13/2024
    Impact of FADS genotype on polyunsaturated fatty acid content in human milk extracellular vesicles: A genetic association study.

    Impact of FADS genotype on polyunsaturated fatty acid content in human milk extracellular vesicles: A genetic association study.
    Miklavcic JJ, Paterson N, Hahn-Holbrook J, Glynn L.

    05/23/2024
    Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.

    Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.
    Wu X, Jiang L, Qi H, Hu C, Jia X, Lin H, Wang S, Lin L, Zhang Y, Zheng R, Li M, Wang T, Zhao Z, Xu M, Xu Y, Chen Y, Zheng J, Bi Y, Lu J., Free PMC Article

    03/8/2024
    Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men.

    Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men.
    Fridén M, Olsson E, Lind L, Rosqvist F, Risérus U., Free PMC Article

    02/1/2024
    Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

    Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.
    Mathieson I, Day FR, Barban N, Tropf FC, Brazel DM, eQTLGen Consortium, BIOS Consortium, Vaez A, van Zuydam N, Bitarello BD, Gardner EJ, Akimova ET, Azad A, Bergmann S, Bielak LF, Boomsma DI, Bosak K, Brumat M, Buring JE, Cesarini D, Chasman DI, Chavarro JE, Cocca M, Concas MP, Davey Smith G, Davies G, Deary IJ, Esko T, Faul JD, FinnGen Study, Franco O, Ganna A, Gaskins AJ, Gelemanovic A, de Geus EJC, Gieger C, Girotto G, Gopinath B, Grabe HJ, Gunderson EP, Hayward C, He C, van Heemst D, Hill WD, Hoffmann ER, Homuth G, Hottenga JJ, Huang H, Hyppӧnen E, Ikram MA, Jansen R, Johannesson M, Kamali Z, Kardia SLR, Kavousi M, Kifley A, Kiiskinen T, Kraft P, Kühnel B, Langenberg C, Liew G, Lifelines Cohort Study, Lind PA, Luan J, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Mbarek H, McCarthy MI, McMahon G, Medland SE, Meitinger T, Metspalu A, Mihailov E, Milani L, Missmer SA, Mitchell P, Møllegaard S, Mook-Kanamori DO, Morgan A, van der Most PJ, de Mutsert R, Nauck M, Nolte IM, Noordam R, Penninx BWJH, Peters A, Peyser PA, Polašek O, Power C, Pribisalic A, Redmond P, Rich-Edwards JW, Ridker PM, Rietveld CA, Ring SM, Rose LM, Rueedi R, Shukla V, Smith JA, Stankovic S, Stefánsson K, Stöckl D, Strauch K, Swertz MA, Teumer A, Thorleifsson G, Thorsteinsdottir U, Thurik AR, Timpson NJ, Turman C, Uitterlinden AG, Waldenberger M, Wareham NJ, Weir DR, Willemsen G, Zhao JH, Zhao W, Zhao Y, Snieder H, den Hoed M, Ong KK, Mills MC, Perry JRB.

    05/25/2023
    FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer.

    FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer.
    Xu C, Gu L, Hu L, Jiang C, Li Q, Sun L, Zhou H, Liu Y, Xue H, Li J, Zhang Z, Zhang X, Xu Q., Free PMC Article

    04/14/2023
    Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies.

    Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies.
    Bobiński R, Mazurek U, Zmarzly N, Ulman-Włodarz I, Dutka M, Pizon M, Pollok-Waksmańska W, Pielesz A, Hajduga M, Zimmer K, Bujok J, Pająk C, Ilczak T.

    03/21/2023
    Effect of FADS1 rs174556 Genotype on Polyunsaturated Fatty Acid Status: A Systematic Review and Meta-Analysis.

    Effect of FADS1 rs174556 Genotype on Polyunsaturated Fatty Acid Status: A Systematic Review and Meta-Analysis.
    Wu WC, Wu PY, Chan CY, Lee MF, Huang CY., Free PMC Article

    03/15/2023
    Association of Fatty Acid Desaturase 1 rs174547 Polymorphism with the Composition of Long-Chain Polyunsaturated Fatty Acids in Serum Glycerophospholipids during Pregnancy.

    Association of Fatty Acid Desaturase 1 rs174547 Polymorphism with the Composition of Long-Chain Polyunsaturated Fatty Acids in Serum Glycerophospholipids during Pregnancy.
    Kawabata T, Fukuoka H, Harada M, Shoji K, Kubo Y, Mori C, Sakurai K, Ohkubo T, Oshida K, Yamashiro Y., Free PMC Article

    02/14/2023
    Investigation of Maternal Diet and FADS1 Polymorphism Associated with Long-Chain Polyunsaturated Fatty Acid Compositions in Human Milk.

    Investigation of Maternal Diet and FADS1 Polymorphism Associated with Long-Chain Polyunsaturated Fatty Acid Compositions in Human Milk.
    Niwa S, Kawabata T, Shoji K, Ogata H, Kagawa Y, Nakayama K, Yanagisawa Y, Iwamoto S, Tatsuta N, Asato K, Arima T, Yaegashi N, Nakai K., Free PMC Article

    06/11/2022
    CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.

    CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.
    Ding Y, Tu P, Chen Y, Huang Y, Pan X, Chen W., Free PMC Article

    03/19/2022
    FADS1 and FADS2 Gene Polymorphisms Modulate the Relationship of Omega-3 and Omega-6 Fatty Acid Plasma Concentrations in Gestational Weight Gain: A NISAMI Cohort Study.

    FADS1 and FADS2 Gene Polymorphisms Modulate the Relationship of Omega-3 and Omega-6 Fatty Acid Plasma Concentrations in Gestational Weight Gain: A NISAMI Cohort Study.
    Santana JDM, Pereira M, Carvalho GQ, Gouveia Peluzio MDC, Drumond Louro I, Santos DBD, Oliveira AM., Free PMC Article

    03/19/2022
    Single nucleotide polymorphism of fatty acid desaturase gene and breast cancer risk in estrogen receptor subtype.

    Single nucleotide polymorphism of fatty acid desaturase gene and breast cancer risk in estrogen receptor subtype.
    Preethika A, Sonkusare S, Suchetha Kumari N.

    03/19/2022
    FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents.

    FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents.
    Metelcová T, Vaňková M, Zamrazilová H, Hovhannisyan M, Staňková B, Tvrzická E, Hill M, Hainer V, Včelák J, Kunešová M.

    01/29/2022
    Association between FADS1 rs174547 and levels of long-chain PUFA: a meta-analysis.

    Association between FADS1 rs174547 and levels of long-chain PUFA: a meta-analysis.
    Wang Y, Tang Y, Ji Y, Xu W, Ullah N, Yu H, Wu Y, Xie L.

    01/29/2022
    Associations of umbilical cord fatty acid profiles and desaturase enzyme indices with birth weight for gestational age in Japanese infants.

    Associations of umbilical cord fatty acid profiles and desaturase enzyme indices with birth weight for gestational age in Japanese infants.
    Matsumoto A, Kawabata T, Kagawa Y, Shoji K, Kimura F, Miyazawa T, Tatsuta N, Arima T, Yaegashi N, Nakai K.

    12/4/2021
    Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus.

    Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus.
    Shetty SS, Suchetha KN, Harshini D, Sharmila KP, Rai S., Free PMC Article

    11/6/2021
    Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.

    Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.
    Wang C, Murphy J, Delaney KZ, Khor N, Morais JA, Tsoukas MA, Lowry DE, Mutch DM, Santosa S., Free PMC Article

    10/9/2021
    FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.

    FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.
    Zec MM, Stojković L, Zeković M, Pokimica B, Zivkovic M, Stankovic A, Glibetic M.

    10/2/2021
    A Common Polymorphism in the FADS1 Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP1.

    A Common Polymorphism in the FADS1 Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP1.
    Beehler K, Nikpay M, Lau P, Dang AT, Lagace TA, Soubeyrand S, McPherson R.

    09/4/2021
    FADS1 (Fatty Acid Desaturase 1) Genotype Associates With Aortic Valve FADS mRNA Expression, Fatty Acid Content and Calcification.

    FADS1 (Fatty Acid Desaturase 1) Genotype Associates With Aortic Valve FADS mRNA Expression, Fatty Acid Content and Calcification.
    Plunde O, Larsson SC, Artiach G, Thanassoulis G, Carracedo M, Franco-Cereceda A, Eriksson P, Bäck M., Free PMC Article

    08/21/2021
    Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.

    Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.
    Thomas T, Cendali F, Fu X, Gamboni F, Morrison EJ, Beirne J, Nemkov T, Antonelou MH, Kriebardis A, Welsby I, Hay A, Dziewulska KH, Busch MP, Kleinman S, Buehler PW, Spitalnik SL, Zimring JC, D'Alessandro A., Free PMC Article

    07/24/2021
    Differences in erythrocyte phospholipid membrane long-chain polyunsaturated fatty acids and the prevalence of fatty acid desaturase genotype among African Americans and European Americans.

    Differences in erythrocyte phospholipid membrane long-chain polyunsaturated fatty acids and the prevalence of fatty acid desaturase genotype among African Americans and European Americans.
    Rifkin SB, Shrubsole MJ, Cai Q, Smalley WE, Ness RM, Swift LL, Milne G, Zheng W, Murff HJ.

    06/5/2021
    FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women.

    FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women.
    Fujii TMM, Norde MM, Fisberg RM, Marchioni DML, Ordovás JM, Rogero MM.

    05/29/2021
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