| Forced LMX1A expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons. | Forced LMX1A expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons.
Rifes P, Kajtez J, Christiansen JR, Schörling A, Rathore GS, Wolf DA, Heuer A, Kirkeby A., Free PMC Article | 06/25/2024 |
| ceRNA network of lncRNA MIR210HG/miR-377-3p/LMX1A in malignant proliferation of glioma cells. | ceRNA network of lncRNA MIR210HG/miR-377-3p/LMX1A in malignant proliferation of glioma cells.
Yu Z, Che N, He Y, Zhang B. | 12/3/2022 |
| Novel Molecular Genetic Etiology of Asymmetric Hearing Loss: Autosomal-Dominant LMX1A Variants. | Novel Molecular Genetic Etiology of Asymmetric Hearing Loss: Autosomal-Dominant LMX1A Variants.
Lee SY, Soon Yoo H, Hee Han J, Hee Lee D, Soo Park S, Hwan Suh M, Ho Lee J, Oh SH, Choi BY. | 10/29/2022 |
| Update on CD164 and LMX1A genes to strengthen their causative role in autosomal dominant hearing loss. | Update on CD164 and LMX1A genes to strengthen their causative role in autosomal dominant hearing loss.
Oziębło D, Lee SY, Leja ML, Sarosiak A, Bałdyga N, Skarżyński H, Kim Y, Han JH, Yoo HS, Park MH, Choi BY, Ołdak M. | 05/7/2022 |
| Novel genotype-phenotype correlation of functionally characterized LMX1A variants linked to sensorineural hearing loss. | Novel genotype-phenotype correlation of functionally characterized LMX1A variants linked to sensorineural hearing loss.
Lee SY, Han JH, Carandang M, Kim MY, Kim B, Yi N, Kim J, Kim BJ, Oh DY, Koo JW, Lee JH, Oh SH, Choi BY. | 01/15/2022 |
| Epigenetic Silencing of LMX1A Contributes to Cancer Progression in Lung Cancer Cells. | Epigenetic Silencing of LMX1A Contributes to Cancer Progression in Lung Cancer Cells.
Wu TH, Chang SY, Shih YL, Chian CF, Chang H, Lin YW., Free PMC Article | 02/27/2021 |
| Circular RNA circMTO1 Suppresses RCC Cancer Cell Progression via miR9/LMX1A Axis. | Circular RNA circMTO1 Suppresses RCC Cancer Cell Progression via miR9/LMX1A Axis.
Li K, Wan CL, Guo Y., Free PMC Article | 11/21/2020 |
| LINC00682 inhibits gastric cancer cell progression via targeting microRNA-9-LMX1A signaling axis. | LINC00682 inhibits gastric cancer cell progression via targeting microRNA-9-LMX1A signaling axis.
Zhang X, Li J, Li F, Zhao Z, Feng L., Free PMC Article | 10/24/2020 |
| Knockdown of LncRNA SCAMP1 suppressed malignant biological behaviours of glioma cells via modulating miR-499a-5p/LMX1A/NLRC5 pathway. | Knockdown of LncRNA SCAMP1 suppressed malignant biological behaviours of glioma cells via modulating miR-499a-5p/LMX1A/NLRC5 pathway.
Zong Z, Song Y, Xue Y, Ruan X, Liu X, Yang C, Zheng J, Cao S, Li Z, Liu Y., Free PMC Article | 09/5/2020 |
| Knockdown of ANGPTL4 rescued the tumor suppressive phenotype of LMX1A overexpression, which indicated that LMX1A upregulates ANGPTL4 to exert its role. Mechanistically, we found that LMX1A inhibited the expression of the oncogene C-Myc, which is alleviated by ANGPTL4 knockdown. | LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancer.
Qian P, Li J, Zhang X, Li F, Bei S, Li H, Sun Q, Feng L., Free PMC Article | 03/21/2020 |
| miR-9 selectively targets LMX1A to promote gastric cancer cell progression. | microRNA-9 selectively targets LMX1A to promote gastric cancer cell progression.
Zhang X, Qian Y, Li F, Bei S, Li M, Feng L. | 05/25/2019 |
| Our results indicate an important influence of the neurodevelopment genes, PBX1, LMX1A, and SLITRK1 in obsessive-compulsive disorder susceptibility | Gene variations in PBX1, LMX1A and SLITRK1 are associated with obsessive-compulsive disorder and its clinical features.
Melo-Felippe FB, Fontenelle LF, Kohlrausch FB. | 04/6/2019 |
| Our results suggest that LMX1A is involved in both human autosomal recessive and dominant sensorineural hearing impairmen | A variant in LMX1A causes autosomal recessive severe-to-profound hearing impairment.
Schrauwen I, Chakchouk I, Liaqat K, Jan A, Nasir A, Hussain S, Nickerson DA, Bamshad MJ, Ullah A, Ahmad W, Leal SM., Free PMC Article | 03/30/2019 |
| The late-onset progressive phenotype and the absence of cochleovestibular malformations on computed tomography scans indicate that heterozygous defects of LMX1A do not result in severe developmental abnormalities in humans. | Heterozygous missense variants of LMX1A lead to nonsyndromic hearing impairment and vestibular dysfunction.
Wesdorp M, de Koning Gans PAM, Schraders M, Oostrik J, Huynen MA, Venselaar H, Beynon AJ, van Gaalen J, Piai V, Voermans N, van Rossum MM, Hartel BP, Lelieveld SH, Wiel L, Verbist B, Rotteveel LJ, van Dooren MF, Lichtner P, Kunst HPM, Feenstra I, Admiraal RJC, DOOFNL Consortium, Yntema HG, Hoefsloot LH, Pennings RJE, Kremer H., Free PMC Article | 02/2/2019 |
| Study revealed an anti-metastatic role of LMX1A in gastric cancer which is mediated by the negative regulation of beta-catenin signaling target genes. | LMX1A inhibits metastasis of gastric cancer cells through negative regulation of β-catenin.
Feng L, Xie Y, Zhao Z, Lian W. | 02/4/2017 |
| Polymorphisms of dopamine pathway gene aLMX1A is associated with cognitive performance in Bipolar disorder. | Polymorphisms of dopamine pathway genes NRG1 and LMX1A are associated with cognitive performance in bipolar disorder.
Rolstad S, Pålsson E, Ekman CJ, Eriksson E, Sellgren C, Landén M. | 07/16/2016 |
| Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area. [Review] | Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.
Doucet-Beaupré H, Ang SL, Lévesque M. | 04/30/2016 |
| SNPs of the LMX1A gene might be associated with the susceptibility to congenital scoliosis and different clinical phenotypes in the Chinese Han population. | Association of LMX1A genetic polymorphisms with susceptibility to congenital scoliosis in Chinese Han population.
Wu N, Yuan S, Liu J, Chen J, Fei Q, Liu S, Su X, Wang S, Zhang J, Li S, Wang Y, Qiu G, Wu Z. | 10/10/2015 |
| To our best knowledge, this is the first report demonstrating the application of TAT-LMX1A recombinant protein to enhance hESC differentiation to DA as shown by the expression of DA specific makers. | Efficient differentiation of human embryonic stem cells toward dopaminergic neurons using recombinant LMX1A factor.
Fathi A, Rasouli H, Yeganeh M, Salekdeh GH, Baharvand H. | 09/26/2015 |
| LMX1A is weakly methylated in cervical adenocarcinomas compared with controls, in a metastatic stage of cervical cancer. | High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma.
Chang CC, Huang RL, Wang HC, Liao YP, Yu MH, Lai HC. | 10/18/2014 |
| higher expression is associated with more advanced neoplasm staging in Chinese patients with pancreatic ductal adenocarcinomas | The correlations of LMX1A and osteopontin expression to the clinicopathologic stages in pancreatic adenocarcinoma.
Tsai WC, Lin CK, Yang YS, Chan DC, Gao HW, Chang FN, Jin JS. | 04/5/2014 |
| these data imply that Sp1 and EZH2 may activate LMX1A expression upon oncogenic stress during cervical cancer development. | The role of Sp1 and EZH2 in the regulation of LMX1A in cervical cancer cells.
Lin WC, Yan MD, Yu PN, Li HJ, Kuo CC, Hsu CL, Lin YW. | 03/1/2014 |
| Higher immunostaining intensity for OPN and LMX1A correlated with WHO grades for meningiomas and some gliomas. Contrary to our expectations, LMX1A staining in WHO grade IV gliomas was shown to be weaker than in WHO grade III tumours. | The association of osteopontin and LMX1A expression with World Health Organization grade in meningiomas and gliomas.
Tsai WC, Lee HS, Lin CK, Chen A, Nieh S, Ma HI. | 04/20/2013 |
| The Lmx1a can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. | Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells.
Panman L, Andersson E, Alekseenko Z, Hedlund E, Kee N, Mong J, Uhde CW, Deng Q, Sandberg R, Stanton LW, Ericson J, Perlmann T. | 03/3/2012 |
| One single nucleotide polymorphisms of lmx1a was strongly associated with the magnitude of training-related gains in verbal working memory | Preliminary evidence that allelic variation in the LMX1A gene influences training-related working memory improvement.
Bellander M, Brehmer Y, Westerberg H, Karlsson S, Fürth D, Bergman O, Eriksson E, Bäckman L. | 09/17/2011 |