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    LPO lactoperoxidase [ Homo sapiens (human) ]

    Gene ID: 4025, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The crystal structure of the complex of LPO with MZY showed that MZY bound to LPO in the substrate-binding site on the distal heme side. MZY was oriented in the substrate-binding site in such a way that the sulfur atom is at a distance of 2.58 A from the heme iron

    Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution.
    Sirohi HV, Singh PK, Iqbal N, Sharma P, Singh AK, Kaur P, Sharma S, Singh TP.

    10/21/2017
    LPO mRNA was undetectable in the gastric mucosa.

    The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori.
    Li H, Zhou Y, Zheng Y, Guo H, Gao L, Chen P, Feng D, Wu L, Yang M, Qi Y, Guo H, Chang Y, Chu FF, Gao Q., Free PMC Article

    07/15/2017
    Oral peroxidase activity as a marker of chronic alcohol abuse may help in the diagnosis of alcoholism.

    The effect of chronic alcohol intoxication and smoking on the activity of oral peroxidase.
    Waszkiewicz N, Zalewska A, Szajda SD, Szulc A, Kępka A, Minarowska A, Wojewódzka-Żelezniakowicz M, Konarzewska B, Chojnowska S, Supronowicz ZB, Ladny JR, Zwierz K.

    02/26/2016
    establish urate as a likely physiological substrate for LPO that will influence host defense and give rise to reactive electrophilic metabolites

    Uric acid and thiocyanate as competing substrates of lactoperoxidase.
    Seidel A, Parker H, Turner R, Dickerhof N, Khalilova IS, Wilbanks SM, Kettle AJ, Jameson GN., Free PMC Article

    02/21/2015
    High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase.

    The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries.
    Gornowicz A, Tokajuk G, Bielawska A, Maciorkowska E, Jabłoński R, Wójcicka A, Bielawski K., Free PMC Article

    12/20/2014
    Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

    Polymorphisms in innate immunity genes and risk of childhood leukemia.
    Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article

    06/30/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (3) articles

    Risk of meningioma and common variation in genes related to innate immunity.
    Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD.

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    Common variation in genes related to innate immunity and risk of adult glioma.
    Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ.

    04/7/2010
    Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.
    Bhatti P, Stewart PA, Hutchinson A, Rothman N, Linet MS, Inskip PD, Rajaraman P., Free PMC Article

    06/24/2009
    Splice variants may contribute to LPO molecular heterogeneity and its regulation by intracellular compartmental localization in respiratory epithelium.

    Molecular heterogeneity and alternative splicing of human lactoperoxidase.
    Fragoso MA, Torbati A, Fregien N, Conner GE., Free PMC Article

    01/21/2010
    Analysis of the role of thiocyanate (SCN-), in modulating the catalytic activity of myeloperoxidase (MPO) and other members of the lactoperoxidase (LPO) and eosinophil peroxidase (EPO)

    Thiocyanate modulates the catalytic activity of mammalian peroxidases.
    Tahboub YR, Galijasevic S, Diamond MP, Abu-Soud HM.

    01/21/2010
    lactoperoxidase may play an important role in the metabolic events associated with Parkinson's disease

    The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds.
    Everse J, Coates PW.

    01/21/2010
    a functional LPO system exists in human airways and may contribute to airway host defense against infection

    Lactoperoxidase and human airway host defense.
    Wijkstrom-Frei C, El-Chemaly S, Ali-Rachedi R, Gerson C, Cobas MA, Forteza R, Salathe M, Conner GE.

    01/21/2010
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